Survival of children under 3 years old with medulloblastoma: a study from the Mexican Cooperative Group for Childhood Malignancies (AMOHP)
The prognosis of medulloblastoma in children under 3 years of age is poor. A retrospective analysis was performed to evaluate children under 3 years of age with medulloblastoma. Overall survival (OS) and progression-free survival (PFS) were assessed in children with and without metastasis. A total o...
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| Veröffentlicht in: | Child's nervous system 2002-02, Vol.18 (1-2), p.38-42 |
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| creator | RIVERA-LUNA, Roberto LOPEZ, Enrique RIVERA-MARQUEZ, Hugo RIVERA-ORTEGON, Francisco ALTAMIRANO-ALVAREZ, Eduardo MERCADO, Gabriela COVARRUBIAS, Gilberto RUEDA-FRANCO, Fernando MARHX-BRACHO, Alfonso GUTIERREZ, Pedro |
| description | The prognosis of medulloblastoma in children under 3 years of age is poor.
A retrospective analysis was performed to evaluate children under 3 years of age with medulloblastoma. Overall survival (OS) and progression-free survival (PFS) were assessed in children with and without metastasis.
A total of 534 children were diagnosed with medulloblastoma during the study period, 49 (9.1%) of whom were under 3 years of age and were evaluated. Their ages ranged from 5 to 35 months with a mean of 18.5 months. In 39 (79.6%) of these patients the tumors were staged as T3M0 or under, while 10 (20.4%) had metastasis at diagnosis. The OS was 38% and PFS 37% in the whole series, while PFS was 32% in those with metastasis and 40% in those without ( P=0.78). For those who received radiotherapy the PFS was 62%, and in those not treated with radiotherapy PFS was nil ( P=0.0001). When the children were divided into those who received surgical treatment plus chemotherapy and those who received surgery plus radiotherapy plus chemotherapy, the PFS was nil and 66%, respectively ( P=0.00001).
Because of the high morbidity of radiotherapy in children under 3 years old, surgery continues to be the basis of improved prognosis, followed by chemotherapy. |
| doi_str_mv | 10.1007/s00381-001-0527-2 |
| format | Article |
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A retrospective analysis was performed to evaluate children under 3 years of age with medulloblastoma. Overall survival (OS) and progression-free survival (PFS) were assessed in children with and without metastasis.
A total of 534 children were diagnosed with medulloblastoma during the study period, 49 (9.1%) of whom were under 3 years of age and were evaluated. Their ages ranged from 5 to 35 months with a mean of 18.5 months. In 39 (79.6%) of these patients the tumors were staged as T3M0 or under, while 10 (20.4%) had metastasis at diagnosis. The OS was 38% and PFS 37% in the whole series, while PFS was 32% in those with metastasis and 40% in those without ( P=0.78). For those who received radiotherapy the PFS was 62%, and in those not treated with radiotherapy PFS was nil ( P=0.0001). When the children were divided into those who received surgical treatment plus chemotherapy and those who received surgery plus radiotherapy plus chemotherapy, the PFS was nil and 66%, respectively ( P=0.00001).
Because of the high morbidity of radiotherapy in children under 3 years old, surgery continues to be the basis of improved prognosis, followed by chemotherapy.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-001-0527-2</identifier><identifier>PMID: 11935242</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Cerebellar Neoplasms - drug therapy ; Cerebellar Neoplasms - radiotherapy ; Cerebellar Neoplasms - surgery ; Child, Preschool ; Combined Modality Therapy ; Cranial Fossa, Posterior ; Female ; Humans ; Infant ; Male ; Medical sciences ; Medulloblastoma - drug therapy ; Medulloblastoma - radiotherapy ; Medulloblastoma - surgery ; Neurology ; Neurosurgical Procedures ; Retrospective Studies ; Survival Analysis ; Treatment Outcome ; Tropical medicine ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Child's nervous system, 2002-02, Vol.18 (1-2), p.38-42</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-a16e3c8c48200b59475b41499b1bb518d37de79a8c3c507c757cefd988f535ec3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13518359$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11935242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RIVERA-LUNA, Roberto</creatorcontrib><creatorcontrib>LOPEZ, Enrique</creatorcontrib><creatorcontrib>RIVERA-MARQUEZ, Hugo</creatorcontrib><creatorcontrib>RIVERA-ORTEGON, Francisco</creatorcontrib><creatorcontrib>ALTAMIRANO-ALVAREZ, Eduardo</creatorcontrib><creatorcontrib>MERCADO, Gabriela</creatorcontrib><creatorcontrib>COVARRUBIAS, Gilberto</creatorcontrib><creatorcontrib>RUEDA-FRANCO, Fernando</creatorcontrib><creatorcontrib>MARHX-BRACHO, Alfonso</creatorcontrib><creatorcontrib>GUTIERREZ, Pedro</creatorcontrib><title>Survival of children under 3 years old with medulloblastoma: a study from the Mexican Cooperative Group for Childhood Malignancies (AMOHP)</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><description>The prognosis of medulloblastoma in children under 3 years of age is poor.
A retrospective analysis was performed to evaluate children under 3 years of age with medulloblastoma. Overall survival (OS) and progression-free survival (PFS) were assessed in children with and without metastasis.
A total of 534 children were diagnosed with medulloblastoma during the study period, 49 (9.1%) of whom were under 3 years of age and were evaluated. Their ages ranged from 5 to 35 months with a mean of 18.5 months. In 39 (79.6%) of these patients the tumors were staged as T3M0 or under, while 10 (20.4%) had metastasis at diagnosis. The OS was 38% and PFS 37% in the whole series, while PFS was 32% in those with metastasis and 40% in those without ( P=0.78). For those who received radiotherapy the PFS was 62%, and in those not treated with radiotherapy PFS was nil ( P=0.0001). When the children were divided into those who received surgical treatment plus chemotherapy and those who received surgery plus radiotherapy plus chemotherapy, the PFS was nil and 66%, respectively ( P=0.00001).
Because of the high morbidity of radiotherapy in children under 3 years old, surgery continues to be the basis of improved prognosis, followed by chemotherapy.</description><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cerebellar Neoplasms - drug therapy</subject><subject>Cerebellar Neoplasms - radiotherapy</subject><subject>Cerebellar Neoplasms - surgery</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Cranial Fossa, Posterior</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medulloblastoma - drug therapy</subject><subject>Medulloblastoma - radiotherapy</subject><subject>Medulloblastoma - surgery</subject><subject>Neurology</subject><subject>Neurosurgical Procedures</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>Tropical medicine</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1vEzEQhi0EomnhB3BBcwGVw1J_rOM1tyqCFqlRkShny2vPEiPvOti7ofkL_dVslEg9jObyzCvN8xLyjtHPjFJ1VSgVDasonUdyVfEXZMFqISoqJH1JFpTLZaVoTc_IeSl_Zk42XL8mZ4xpIXnNF-Tp55R3YWcjpA7cJkSfcYBp8JhBwB5tLpCih39h3ECPfooxtdGWMfX2C1go4-T30OXUw7hBWONjcHaAVUpbzHYMO4SbnKYtdCnD6pC_ScnD2sbwe7CDC1jg8np9f_vj0xvyqrOx4NvTviC_vn19WN1Wd_c331fXd5UTXI2VZUsUrnF1wyltpa6VbGtWa92ytpWs8UJ5VNo2TjhJlVNSOey8bppOColOXJCPx9xtTn8nLKPpQ3EYox0wTcUoJpXSy3oG2RF0OZWSsTPbHHqb94ZRcyjAHAsws1hzKMDw-eb9KXxqZ13PFyfjM_DhBNjibOzyQUJ55sT8gpBa_Afrqo6O</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>RIVERA-LUNA, Roberto</creator><creator>LOPEZ, Enrique</creator><creator>RIVERA-MARQUEZ, Hugo</creator><creator>RIVERA-ORTEGON, Francisco</creator><creator>ALTAMIRANO-ALVAREZ, Eduardo</creator><creator>MERCADO, Gabriela</creator><creator>COVARRUBIAS, Gilberto</creator><creator>RUEDA-FRANCO, Fernando</creator><creator>MARHX-BRACHO, Alfonso</creator><creator>GUTIERREZ, Pedro</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020201</creationdate><title>Survival of children under 3 years old with medulloblastoma: a study from the Mexican Cooperative Group for Childhood Malignancies (AMOHP)</title><author>RIVERA-LUNA, Roberto ; LOPEZ, Enrique ; RIVERA-MARQUEZ, Hugo ; RIVERA-ORTEGON, Francisco ; ALTAMIRANO-ALVAREZ, Eduardo ; MERCADO, Gabriela ; COVARRUBIAS, Gilberto ; RUEDA-FRANCO, Fernando ; MARHX-BRACHO, Alfonso ; GUTIERREZ, Pedro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-a16e3c8c48200b59475b41499b1bb518d37de79a8c3c507c757cefd988f535ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cerebellar Neoplasms - drug therapy</topic><topic>Cerebellar Neoplasms - radiotherapy</topic><topic>Cerebellar Neoplasms - surgery</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Cranial Fossa, Posterior</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medulloblastoma - drug therapy</topic><topic>Medulloblastoma - radiotherapy</topic><topic>Medulloblastoma - surgery</topic><topic>Neurology</topic><topic>Neurosurgical Procedures</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>Tropical medicine</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RIVERA-LUNA, Roberto</creatorcontrib><creatorcontrib>LOPEZ, Enrique</creatorcontrib><creatorcontrib>RIVERA-MARQUEZ, Hugo</creatorcontrib><creatorcontrib>RIVERA-ORTEGON, Francisco</creatorcontrib><creatorcontrib>ALTAMIRANO-ALVAREZ, Eduardo</creatorcontrib><creatorcontrib>MERCADO, Gabriela</creatorcontrib><creatorcontrib>COVARRUBIAS, Gilberto</creatorcontrib><creatorcontrib>RUEDA-FRANCO, Fernando</creatorcontrib><creatorcontrib>MARHX-BRACHO, Alfonso</creatorcontrib><creatorcontrib>GUTIERREZ, Pedro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RIVERA-LUNA, Roberto</au><au>LOPEZ, Enrique</au><au>RIVERA-MARQUEZ, Hugo</au><au>RIVERA-ORTEGON, Francisco</au><au>ALTAMIRANO-ALVAREZ, Eduardo</au><au>MERCADO, Gabriela</au><au>COVARRUBIAS, Gilberto</au><au>RUEDA-FRANCO, Fernando</au><au>MARHX-BRACHO, Alfonso</au><au>GUTIERREZ, Pedro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival of children under 3 years old with medulloblastoma: a study from the Mexican Cooperative Group for Childhood Malignancies (AMOHP)</atitle><jtitle>Child's nervous system</jtitle><addtitle>Childs Nerv Syst</addtitle><date>2002-02-01</date><risdate>2002</risdate><volume>18</volume><issue>1-2</issue><spage>38</spage><epage>42</epage><pages>38-42</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>The prognosis of medulloblastoma in children under 3 years of age is poor.
A retrospective analysis was performed to evaluate children under 3 years of age with medulloblastoma. Overall survival (OS) and progression-free survival (PFS) were assessed in children with and without metastasis.
A total of 534 children were diagnosed with medulloblastoma during the study period, 49 (9.1%) of whom were under 3 years of age and were evaluated. Their ages ranged from 5 to 35 months with a mean of 18.5 months. In 39 (79.6%) of these patients the tumors were staged as T3M0 or under, while 10 (20.4%) had metastasis at diagnosis. The OS was 38% and PFS 37% in the whole series, while PFS was 32% in those with metastasis and 40% in those without ( P=0.78). For those who received radiotherapy the PFS was 62%, and in those not treated with radiotherapy PFS was nil ( P=0.0001). When the children were divided into those who received surgical treatment plus chemotherapy and those who received surgery plus radiotherapy plus chemotherapy, the PFS was nil and 66%, respectively ( P=0.00001).
Because of the high morbidity of radiotherapy in children under 3 years old, surgery continues to be the basis of improved prognosis, followed by chemotherapy.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11935242</pmid><doi>10.1007/s00381-001-0527-2</doi><tpages>5</tpages></addata></record> |
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| ispartof | Child's nervous system, 2002-02, Vol.18 (1-2), p.38-42 |
| issn | 0256-7040 1433-0350 |
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| subjects | Antineoplastic Agents - therapeutic use Biological and medical sciences Cerebellar Neoplasms - drug therapy Cerebellar Neoplasms - radiotherapy Cerebellar Neoplasms - surgery Child, Preschool Combined Modality Therapy Cranial Fossa, Posterior Female Humans Infant Male Medical sciences Medulloblastoma - drug therapy Medulloblastoma - radiotherapy Medulloblastoma - surgery Neurology Neurosurgical Procedures Retrospective Studies Survival Analysis Treatment Outcome Tropical medicine Tumors of the nervous system. Phacomatoses |
| title | Survival of children under 3 years old with medulloblastoma: a study from the Mexican Cooperative Group for Childhood Malignancies (AMOHP) |
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