The role of CTLA‐4 in induction and maintenance of peripheral T cell tolerance

T cell receptor engagement and the B7‐CD28 / CTLA‐4 signaling pathways play critical roles in T cell activation and regulation. CD28 engagement results in T cell activation, differentiation and survival while CTLA‐4 signals block IL‐2 production, cell cycle progression and T cell differentiation. We...

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Veröffentlicht in:	European journal of immunology 2002-04, Vol.32 (4), p.972-981
Hauptverfasser:	Eagar, Todd N., Karandikar, Nitin J., Bluestone, Jeffrey A., Miller, Stephen D.
Format:	Artikel
Sprache:	eng
Schlagworte:	AB7 antigen Abatacept Amino Acid Sequence Anergy Animals Antigens, CD - immunology Antigens, Differentiation - administration & dosage Antigens, Differentiation - immunology Antigens, Differentiation - pharmacology Autoantigens - administration & dosage Autoantigens - immunology Autoimmune Diseases - immunology Autoimmune Diseases - therapy B7-1 Antigen - immunology B7-2 Antigen Capsid - immunology Capsid Proteins CD28 antigen Cells, Cultured - immunology Clonal Anergy - immunology Costimulation CTLA-4 Antigen CTLA-4 protein Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - therapy Experimental autoimmune encephalomyelitis Female Hypersensitivity, Delayed - immunology Immune Tolerance Immunization Immunoconjugates Inflammation Lymphocyte Activation Membrane Glycoproteins - immunology Mice Mice, Mutant Strains Molecular Sequence Data Myelin Basic Protein - immunology Myelin Proteolipid Protein - administration & dosage Myelin Proteolipid Protein - immunology Ovalbumin - immunology Peptide Fragments - administration & dosage Peptide Fragments - immunology Proteolipid protein Receptors, Antigen, T-Cell - immunology Specific Pathogen-Free Organisms T-Lymphocyte Subsets - immunology Thymectomy Tolerance
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