The Effect of C-Terminal Helix Stabilization on Specific DNA Binding by Monomeric GCN4 Peptides

DNA binding by a 29‐residue, monomeric, GCN4 basic region peptide, GCN4br, as well as by peptide br‐C, a monomeric basic‐region analogue that is helix stabilized at its C‐terminal end by a Lys25, Asp29 side‐chain lactam‐bridged alanine‐rich sequence, was studied at 25°C in an aqueous buffer containi...

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Veröffentlicht in:	Journal of peptide science 2002-03, Vol.8 (3), p.125-136
Hauptverfasser:	Zhang, Min, Wu, Bing, Zhao, Hong, Taylor, John W.
Format:	Artikel
Sprache:	eng
Schlagworte:	basic region bzip protein Circular Dichroism DNA binding DNA-Binding Proteins Dose-Response Relationship, Drug fluorescence assay Fluorescent Dyes - pharmacology GCN4 helix stabilization Kinetics lactam bridge Microscopy, Fluorescence Models, Chemical Oligonucleotides - pharmacology Peptide Biosynthesis Peptides - chemistry Protein Binding Protein Kinases - chemistry Protein Kinases - metabolism Protein Structure, Tertiary Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism
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