Automated Parallel Oocyte Electrophysiology Test station (POETs): a screening platform for identification of ligand-gated ion channel modulators

Ligand-gated ion channels (LGICs) play important roles in the regulation of cellular function and signaling and serve as excellent drug targets. However, fast desensitization of most LGICs limits the choice of reliable methods to identify agonists, antagonists, and/or modulators in a high throughput...

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Veröffentlicht in:	Assay and drug development technologies 2003-10, Vol.1 (5), p.655-663
Hauptverfasser:	Shieh, Char-Chang, Trumbull, Jonathan D, Sarthy, Jay F, McKenna, David G, Parihar, Ashutosh S, Zhang, Xu-Feng, Faltynek, Connie R, Gopalakrishnan, Murali
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Cell Culture Techniques - instrumentation Cell Culture Techniques - methods Cells, Cultured Drug Evaluation, Preclinical - instrumentation Drug Evaluation, Preclinical - methods Electrophysiology - instrumentation Electrophysiology - methods Equipment Design Equipment Failure Analysis Feasibility Studies Ion Channel Gating - drug effects Ion Channel Gating - physiology Ion Channels - drug effects Ion Channels - physiology Ligands Membrane Potentials - drug effects Membrane Potentials - physiology Microelectrodes Oocytes - drug effects Oocytes - physiology Patch-Clamp Techniques - instrumentation Patch-Clamp Techniques - methods Reproducibility of Results Robotics - instrumentation Robotics - methods Sensitivity and Specificity User-Computer Interface Xenopus laevis
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