Complications and cardiovascular risk factors in South Asians and Europeans with early‐onset type 2 diabetes
Background: Type 2 diabetes is a major cardiovascular risk factor, and early‐onset (
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| Veröffentlicht in: | QJM : An International Journal of Medicine 2002-04, Vol.95 (4), p.241-246 |
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| container_title | QJM : An International Journal of Medicine |
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| creator | Chowdhury, T.A. Lasker, S.S. |
| description | Background: Type 2 diabetes is a major cardiovascular risk factor, and early‐onset ( |
| doi_str_mv | 10.1093/qjmed/95.4.241 |
| format | Article |
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Aim: To determine the prevalence of complications, and cardiovascular risk factors at diagnosis, in early‐onset type 2 diabetes, and to compare these between South Asians and Europeans. Design: Prospective study of newly‐diagnosed type 2 diabetes patients aged <40 years, attending hospital and primary care clinics 1999–2001. Methods: Patients were assessed for signs of macrovascular disease, retinopathy, neuropathy and nephropathy. Cardiovascular risk factors were also determined. Results: Overall, 292 patients were enrolled (165 South Asians). Macrovascular disease was more prevalent in South Asians (15.7% vs. 9.4%, p<0.001), as was microvascular disease (27.3% vs. 16.5%, p<0.001), including retinopathy (17.5% vs. 7.9%, p<0.001), and nephropathy (18.1% vs. 7.8%, p<0.001). South Asians had trends towards greater waist:hip ratio (0.95 vs. 0.90), and higher blood pressure (127/80 vs. 123/76 mmHg). HDL cholesterol was lower (1.0 vs. 1.3 mmol/l, p<0.001) and fasting triglycerides higher (1.9 vs. 1.5 mmol/l, p<0.001) in South Asians. Absolute CHD risk was significantly higher in South Asians (16.9% vs. 13.7%, p<0.001). Discussion: Complications were common at diagnosis, with a quarter of all patients having evidence of at least one diabetic complication. South Asians had a higher prevalence of established macrovascular and microvascular disease, compared to Europeans, and a higher risk of CHD, predominantly because of lower HDL cholesterol and higher blood pressure.]]></description><identifier>ISSN: 1460-2725</identifier><identifier>ISSN: 1460-2393</identifier><identifier>EISSN: 1460-2393</identifier><identifier>DOI: 10.1093/qjmed/95.4.241</identifier><identifier>PMID: 11937651</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Asia, Southeastern - ethnology ; Associated diseases and complications ; Biological and medical sciences ; Blood Pressure ; Body Constitution ; Cardiovascular Diseases - ethnology ; Cardiovascular Diseases - etiology ; Chi-Square Distribution ; Cholesterol, HDL - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes. Impaired glucose tolerance ; Diabetic Nephropathies ; Diabetic Retinopathy ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Humans ; Medical sciences ; Prevalence ; Prospective Studies ; Risk Factors ; Statistics, Nonparametric ; Triglycerides - blood ; United Kingdom</subject><ispartof>QJM : An International Journal of Medicine, 2002-04, Vol.95 (4), p.241-246</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Apr 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-d8cf6d72838c691bdc4054a305571401e77e0d630d4f7c51bbe0106134d8b8943</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13623713$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11937651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chowdhury, T.A.</creatorcontrib><creatorcontrib>Lasker, S.S.</creatorcontrib><title>Complications and cardiovascular risk factors in South Asians and Europeans with early‐onset type 2 diabetes</title><title>QJM : An International Journal of Medicine</title><addtitle>QJM</addtitle><description><![CDATA[Background: Type 2 diabetes is a major cardiovascular risk factor, and early‐onset (<40 years) type 2 diabetes is becoming more common. Aim: To determine the prevalence of complications, and cardiovascular risk factors at diagnosis, in early‐onset type 2 diabetes, and to compare these between South Asians and Europeans. Design: Prospective study of newly‐diagnosed type 2 diabetes patients aged <40 years, attending hospital and primary care clinics 1999–2001. Methods: Patients were assessed for signs of macrovascular disease, retinopathy, neuropathy and nephropathy. Cardiovascular risk factors were also determined. Results: Overall, 292 patients were enrolled (165 South Asians). Macrovascular disease was more prevalent in South Asians (15.7% vs. 9.4%, p<0.001), as was microvascular disease (27.3% vs. 16.5%, p<0.001), including retinopathy (17.5% vs. 7.9%, p<0.001), and nephropathy (18.1% vs. 7.8%, p<0.001). South Asians had trends towards greater waist:hip ratio (0.95 vs. 0.90), and higher blood pressure (127/80 vs. 123/76 mmHg). HDL cholesterol was lower (1.0 vs. 1.3 mmol/l, p<0.001) and fasting triglycerides higher (1.9 vs. 1.5 mmol/l, p<0.001) in South Asians. Absolute CHD risk was significantly higher in South Asians (16.9% vs. 13.7%, p<0.001). Discussion: Complications were common at diagnosis, with a quarter of all patients having evidence of at least one diabetic complication. South Asians had a higher prevalence of established macrovascular and microvascular disease, compared to Europeans, and a higher risk of CHD, predominantly because of lower HDL cholesterol and higher blood pressure.]]></description><subject>Adult</subject><subject>Asia, Southeastern - ethnology</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Body Constitution</subject><subject>Cardiovascular Diseases - ethnology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Chi-Square Distribution</subject><subject>Cholesterol, HDL - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - ethnology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Nephropathies</subject><subject>Diabetic Retinopathy</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Statistics, Nonparametric</subject><subject>Triglycerides - blood</subject><subject>United Kingdom</subject><issn>1460-2725</issn><issn>1460-2393</issn><issn>1460-2393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd9qFDEYxYNYbK3eeilBqHezzf9MLsvStUJpBbWINyGTZDDb2ck0mVH3zkfwGX2SZrtjBa--fJxfTsI5ALzCaIGRoqd36413p4ov2IIw_AQcYSZQRaiiT_-eJeGH4HnOa4QQk6x-Bg4xVlQKjo9Av4yboQvWjCH2GZreQWuSC_G7yXbqTIIp5FvYGjvGlGHo4cc4jd_gWQ5m5s-nFAe_236EoniTuu2fX7-LnR_huB08JNAF0_jR5xfgoDVd9i_neQw-r84_LS-qy-t375dnl5VlRIyVq20rnCQ1ra1QuHGWIc4MRZxLzBD2UnrkBEWOtdJy3DQeYSQwZa5uasXoMXi79x1SvJt8HvUmZOu7zvQ-TllLzKXEhBfwzX_gOk6pL3_ThCiOFCa0QIs9ZFPMOflWDylsTNpqjPSuBv1Qg1ZcM11qKBdez65TsxMe8Tn3ApzMQInZdG0yvQ35H0cFoRLvXq72XMij__mom3SrhaSS64svX_VqdSVvrm6k_kDvAS97oSQ</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Chowdhury, T.A.</creator><creator>Lasker, S.S.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Complications and cardiovascular risk factors in South Asians and Europeans with early‐onset type 2 diabetes</title><author>Chowdhury, T.A. ; Lasker, S.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-d8cf6d72838c691bdc4054a305571401e77e0d630d4f7c51bbe0106134d8b8943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Asia, Southeastern - ethnology</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Body Constitution</topic><topic>Cardiovascular Diseases - ethnology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Chi-Square Distribution</topic><topic>Cholesterol, HDL - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - ethnology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Nephropathies</topic><topic>Diabetic Retinopathy</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Statistics, Nonparametric</topic><topic>Triglycerides - blood</topic><topic>United Kingdom</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chowdhury, T.A.</creatorcontrib><creatorcontrib>Lasker, S.S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>QJM : An International Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chowdhury, T.A.</au><au>Lasker, S.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Complications and cardiovascular risk factors in South Asians and Europeans with early‐onset type 2 diabetes</atitle><jtitle>QJM : An International Journal of Medicine</jtitle><addtitle>QJM</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>95</volume><issue>4</issue><spage>241</spage><epage>246</epage><pages>241-246</pages><issn>1460-2725</issn><issn>1460-2393</issn><eissn>1460-2393</eissn><abstract><![CDATA[Background: Type 2 diabetes is a major cardiovascular risk factor, and early‐onset (<40 years) type 2 diabetes is becoming more common. Aim: To determine the prevalence of complications, and cardiovascular risk factors at diagnosis, in early‐onset type 2 diabetes, and to compare these between South Asians and Europeans. Design: Prospective study of newly‐diagnosed type 2 diabetes patients aged <40 years, attending hospital and primary care clinics 1999–2001. Methods: Patients were assessed for signs of macrovascular disease, retinopathy, neuropathy and nephropathy. Cardiovascular risk factors were also determined. Results: Overall, 292 patients were enrolled (165 South Asians). Macrovascular disease was more prevalent in South Asians (15.7% vs. 9.4%, p<0.001), as was microvascular disease (27.3% vs. 16.5%, p<0.001), including retinopathy (17.5% vs. 7.9%, p<0.001), and nephropathy (18.1% vs. 7.8%, p<0.001). South Asians had trends towards greater waist:hip ratio (0.95 vs. 0.90), and higher blood pressure (127/80 vs. 123/76 mmHg). HDL cholesterol was lower (1.0 vs. 1.3 mmol/l, p<0.001) and fasting triglycerides higher (1.9 vs. 1.5 mmol/l, p<0.001) in South Asians. Absolute CHD risk was significantly higher in South Asians (16.9% vs. 13.7%, p<0.001). Discussion: Complications were common at diagnosis, with a quarter of all patients having evidence of at least one diabetic complication. South Asians had a higher prevalence of established macrovascular and microvascular disease, compared to Europeans, and a higher risk of CHD, predominantly because of lower HDL cholesterol and higher blood pressure.]]></abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11937651</pmid><doi>10.1093/qjmed/95.4.241</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Asia, Southeastern - ethnology Associated diseases and complications Biological and medical sciences Blood Pressure Body Constitution Cardiovascular Diseases - ethnology Cardiovascular Diseases - etiology Chi-Square Distribution Cholesterol, HDL - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - ethnology Diabetes. Impaired glucose tolerance Diabetic Nephropathies Diabetic Retinopathy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Humans Medical sciences Prevalence Prospective Studies Risk Factors Statistics, Nonparametric Triglycerides - blood United Kingdom |
| title | Complications and cardiovascular risk factors in South Asians and Europeans with early‐onset type 2 diabetes |
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