Protein Kinase C Inhibits Formation of VA Gene Transcription Initiation Complex

Activation of protein kinase c (PKC) reduces transcription from the polymerase III (pol III)-transcribed adenovirus VA gene. Data presented here support a role for PKC in disrupting the formation of transcription-competent initiation complexes. The study used the plasmids VA and VA/EL (VA gene with...

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Veröffentlicht in:	In vitro cellular & developmental biology. Animal 2003-11, Vol.39 (10), p.460-467
Hauptverfasser:	Shannon, Timothy E, James, Calvin B L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Adenoviruses DNA Polymerase III - metabolism Gene expression regulation Gene Expression Regulation, Viral - physiology Genes HeLa Cells Humans Phosphorylation Plasmids Plasmids - genetics Protein Kinase C - metabolism Repression Restriction Mapping RNA RNA, Viral - genetics Signal Transduction Transcription factors Transcription, Genetic - genetics Transcriptional regulatory elements
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