Development of an assay suitable for high-throughput screening to measure matrix metalloprotease activity

MMPs, part of a family of enzymes with >35 known members, play an important role in tissue remodeling and repair, in the biology of neoplasia, and during development. Hydroxamic and carboxylic acid inhibitors of these proteases have long been available, but their specificities are poor and there...

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Veröffentlicht in:	Assay and drug development technologies 2003-06, Vol.1 (3), p.425-433
Hauptverfasser:	Peppard, Jane, Pham, Quynhchi, Clark, Ambereen, Farley, David, Sakane, Yumi, Graves, Robert, George, Jeanette, Norey, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Collagenases - chemistry Dimethyl Sulfoxide - chemistry Enzyme Inhibitors - chemistry Fluorescent Dyes Humans Matrix Metalloproteinase 13 Matrix Metalloproteinase 9 - chemistry Metalloproteases - analysis Metalloproteases - antagonists & inhibitors Metalloproteases - chemistry Oligopeptides - chemistry Reproducibility of Results Substrate Specificity Time Factors
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