Nuclear factor-kappaB activation in alveolar macrophages requires IkappaB kinase-beta, but not nuclear factor-kappaB inducing kinase

Cytokine mediated activation of alveolar macrophages (AMs) is an important event in the pathogenesis of fibrosing alveolitis (FA). Through membrane-associated antigens, cytokines (e.g., tumor necrosis-factor-alpha and interleukin-1) are believed to activate a common kinase cascade that initiates the...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2002-04, Vol.165 (7), p.996-1004
Hauptverfasser:	Conron, Matthew, Andreakos, Evangelos, Pantelidis, Panagiotis, Smith, Clive, Beynon, Huw L C, Dubois, Roland M, Foxwell, Brian M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Cytokines - metabolism Gene Transfer Techniques Genetic Vectors Humans I-kappa B Kinase In Vitro Techniques Interleukin-6 - metabolism Macrophage Activation Macrophages, Alveolar - metabolism Macrophages, Alveolar - physiology NF-kappa B - genetics NF-kappa B - metabolism NF-kappaB-Inducing Kinase Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Pulmonary Fibrosis - metabolism Transcriptional Activation Tumor Necrosis Factor-alpha - physiology
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