Dynamics of cerebral blood flow autoregulation in hypertensive patients
In hypertensive patients, the upper and lower limits of cerebral autoregulation are shifted to higher levels. However, the dynamics of cerebral autoregulation in hypertensive patients are less well known. We compared the dynamics of cerebral autoregulation in 21 treated hypertensive patients (13 men...
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| Veröffentlicht in: | Journal of the neurological sciences 2002-03, Vol.195 (2), p.139-144 |
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| creator | Traon, Anne Pavy-Le Costes-Salon, Marie-Claude Galinier, Michel Fourcade, Joelle Larrue, Vincent |
| description | In hypertensive patients, the upper and lower limits of cerebral autoregulation are shifted to higher levels. However, the dynamics of cerebral autoregulation in hypertensive patients are less well known. We compared the dynamics of cerebral autoregulation in 21 treated hypertensive patients (13 men and 8 women; mean age: 48.9±13.6 years) and in 21 normotensive subjects (13 men and 8 women; mean age: 51±14.5 years) by transcranial Doppler (TCD) of the middle cerebral artery (MCA) during the acute decrease in blood pressure induced by standing up after 2 min in squatting position. MCA maximal outline blood flow velocity (FV), blood pressure (Finapres) and end-tidal
PCO
2 were continuously monitored and computerised. A cerebral vascular resistance index (CR) was calculated as follows: mean arterial BP/MCA mean FV with normalised changes in CR per second during the blood pressure decrease (CR slope). The CR slope reflecting the rate of cerebral autoregulation did not differ between the two groups and within the hypertensive patients [well controlled (8 patients) and not controlled (13 patients)]. The time to maximum decrease of CR (
T
1) and the time to full recovery of CR after the initial drop (
T
2) were also similar in the two groups (controls
T
1: 11.3±3.1 s,
T
2: 12±5.9 s; hypertensive
T
1: 11.7±2.5 s,
T
2: 10.7±4.5 s) and within hypertensive patients. These findings suggest that the dynamics of cerebral autoregulation are well preserved in hypertensive patients, with no difference according to the efficiency of treatment of hypertension. |
| doi_str_mv | 10.1016/S0022-510X(02)00010-2 |
| format | Article |
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PCO
2 were continuously monitored and computerised. A cerebral vascular resistance index (CR) was calculated as follows: mean arterial BP/MCA mean FV with normalised changes in CR per second during the blood pressure decrease (CR slope). The CR slope reflecting the rate of cerebral autoregulation did not differ between the two groups and within the hypertensive patients [well controlled (8 patients) and not controlled (13 patients)]. The time to maximum decrease of CR (
T
1) and the time to full recovery of CR after the initial drop (
T
2) were also similar in the two groups (controls
T
1: 11.3±3.1 s,
T
2: 12±5.9 s; hypertensive
T
1: 11.7±2.5 s,
T
2: 10.7±4.5 s) and within hypertensive patients. These findings suggest that the dynamics of cerebral autoregulation are well preserved in hypertensive patients, with no difference according to the efficiency of treatment of hypertension.</description><identifier>ISSN: 0022-510X</identifier><identifier>EISSN: 1878-5883</identifier><identifier>DOI: 10.1016/S0022-510X(02)00010-2</identifier><identifier>PMID: 11897244</identifier><identifier>CODEN: JNSCAG</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - physiology ; Brain - blood supply ; Brain - physiopathology ; Cardiology. Vascular system ; Cerebral Arteries - physiopathology ; Cerebral autoregulation ; Cerebrovascular Circulation - physiology ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Female ; Hemodynamics - physiology ; Homeostasis - physiology ; Humans ; Hypertension ; Hypertension - physiopathology ; Male ; Medical sciences ; Middle Aged ; Reference Values ; Transcranial Doppler</subject><ispartof>Journal of the neurological sciences, 2002-03, Vol.195 (2), p.139-144</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-dc6685b8ad6b003a3ef39480327a51a648a52804895a81180fe7f4105f8316c83</citedby><cites>FETCH-LOGICAL-c457t-dc6685b8ad6b003a3ef39480327a51a648a52804895a81180fe7f4105f8316c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022510X02000102$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13541216$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11897244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Traon, Anne Pavy-Le</creatorcontrib><creatorcontrib>Costes-Salon, Marie-Claude</creatorcontrib><creatorcontrib>Galinier, Michel</creatorcontrib><creatorcontrib>Fourcade, Joelle</creatorcontrib><creatorcontrib>Larrue, Vincent</creatorcontrib><title>Dynamics of cerebral blood flow autoregulation in hypertensive patients</title><title>Journal of the neurological sciences</title><addtitle>J Neurol Sci</addtitle><description>In hypertensive patients, the upper and lower limits of cerebral autoregulation are shifted to higher levels. However, the dynamics of cerebral autoregulation in hypertensive patients are less well known. We compared the dynamics of cerebral autoregulation in 21 treated hypertensive patients (13 men and 8 women; mean age: 48.9±13.6 years) and in 21 normotensive subjects (13 men and 8 women; mean age: 51±14.5 years) by transcranial Doppler (TCD) of the middle cerebral artery (MCA) during the acute decrease in blood pressure induced by standing up after 2 min in squatting position. MCA maximal outline blood flow velocity (FV), blood pressure (Finapres) and end-tidal
PCO
2 were continuously monitored and computerised. A cerebral vascular resistance index (CR) was calculated as follows: mean arterial BP/MCA mean FV with normalised changes in CR per second during the blood pressure decrease (CR slope). The CR slope reflecting the rate of cerebral autoregulation did not differ between the two groups and within the hypertensive patients [well controlled (8 patients) and not controlled (13 patients)]. The time to maximum decrease of CR (
T
1) and the time to full recovery of CR after the initial drop (
T
2) were also similar in the two groups (controls
T
1: 11.3±3.1 s,
T
2: 12±5.9 s; hypertensive
T
1: 11.7±2.5 s,
T
2: 10.7±4.5 s) and within hypertensive patients. These findings suggest that the dynamics of cerebral autoregulation are well preserved in hypertensive patients, with no difference according to the efficiency of treatment of hypertension.</description><subject>Adult</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - physiology</subject><subject>Brain - blood supply</subject><subject>Brain - physiopathology</subject><subject>Cardiology. Vascular system</subject><subject>Cerebral Arteries - physiopathology</subject><subject>Cerebral autoregulation</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Female</subject><subject>Hemodynamics - physiology</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reference Values</subject><subject>Transcranial Doppler</subject><issn>0022-510X</issn><issn>1878-5883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMouq7-BKUXRQ_VSZq02ZPI-gmCBxW8hTSdaKTb1KRd2X9v11306GlgeN6Zl4eQAwpnFGh-_gTAWCoovJ4AOwUACinbICMqC5kKKbNNMvpFdshujB8DlEs52SY7lMpJwTgfkdurRaNnzsTE28RgwDLoOilr76vE1v4r0X3nA771te6cbxLXJO-LFkOHTXRzTNphjU0X98iW1XXE_fUck5eb6-fpXfrweHs_vXxIDRdFl1Ymz6Uopa7yEiDTGdpswiVkrNCC6pxLLZgELidCy6ElWCwspyCszGhuZDYmx6u7bfCfPcZOzVw0WNe6Qd9HVVBRcFbkAyhWoAk-xoBWtcHNdFgoCmppUP0YVEs9Cpj6MajYkDtcP-jLGVZ_qbWyAThaAzoaXdugG-PiH5cJThldFrhYcTjomDsMKppBlcHKBTSdqrz7p8o3j0aMjg</recordid><startdate>20020330</startdate><enddate>20020330</enddate><creator>Traon, Anne Pavy-Le</creator><creator>Costes-Salon, Marie-Claude</creator><creator>Galinier, Michel</creator><creator>Fourcade, Joelle</creator><creator>Larrue, Vincent</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020330</creationdate><title>Dynamics of cerebral blood flow autoregulation in hypertensive patients</title><author>Traon, Anne Pavy-Le ; Costes-Salon, Marie-Claude ; Galinier, Michel ; Fourcade, Joelle ; Larrue, Vincent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-dc6685b8ad6b003a3ef39480327a51a648a52804895a81180fe7f4105f8316c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - physiology</topic><topic>Brain - blood supply</topic><topic>Brain - physiopathology</topic><topic>Cardiology. Vascular system</topic><topic>Cerebral Arteries - physiopathology</topic><topic>Cerebral autoregulation</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Female</topic><topic>Hemodynamics - physiology</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Reference Values</topic><topic>Transcranial Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Traon, Anne Pavy-Le</creatorcontrib><creatorcontrib>Costes-Salon, Marie-Claude</creatorcontrib><creatorcontrib>Galinier, Michel</creatorcontrib><creatorcontrib>Fourcade, Joelle</creatorcontrib><creatorcontrib>Larrue, Vincent</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Traon, Anne Pavy-Le</au><au>Costes-Salon, Marie-Claude</au><au>Galinier, Michel</au><au>Fourcade, Joelle</au><au>Larrue, Vincent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamics of cerebral blood flow autoregulation in hypertensive patients</atitle><jtitle>Journal of the neurological sciences</jtitle><addtitle>J Neurol Sci</addtitle><date>2002-03-30</date><risdate>2002</risdate><volume>195</volume><issue>2</issue><spage>139</spage><epage>144</epage><pages>139-144</pages><issn>0022-510X</issn><eissn>1878-5883</eissn><coden>JNSCAG</coden><abstract>In hypertensive patients, the upper and lower limits of cerebral autoregulation are shifted to higher levels. However, the dynamics of cerebral autoregulation in hypertensive patients are less well known. We compared the dynamics of cerebral autoregulation in 21 treated hypertensive patients (13 men and 8 women; mean age: 48.9±13.6 years) and in 21 normotensive subjects (13 men and 8 women; mean age: 51±14.5 years) by transcranial Doppler (TCD) of the middle cerebral artery (MCA) during the acute decrease in blood pressure induced by standing up after 2 min in squatting position. MCA maximal outline blood flow velocity (FV), blood pressure (Finapres) and end-tidal
PCO
2 were continuously monitored and computerised. A cerebral vascular resistance index (CR) was calculated as follows: mean arterial BP/MCA mean FV with normalised changes in CR per second during the blood pressure decrease (CR slope). The CR slope reflecting the rate of cerebral autoregulation did not differ between the two groups and within the hypertensive patients [well controlled (8 patients) and not controlled (13 patients)]. The time to maximum decrease of CR (
T
1) and the time to full recovery of CR after the initial drop (
T
2) were also similar in the two groups (controls
T
1: 11.3±3.1 s,
T
2: 12±5.9 s; hypertensive
T
1: 11.7±2.5 s,
T
2: 10.7±4.5 s) and within hypertensive patients. These findings suggest that the dynamics of cerebral autoregulation are well preserved in hypertensive patients, with no difference according to the efficiency of treatment of hypertension.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>11897244</pmid><doi>10.1016/S0022-510X(02)00010-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Brain - blood supply Brain - physiopathology Cardiology. Vascular system Cerebral Arteries - physiopathology Cerebral autoregulation Cerebrovascular Circulation - physiology Clinical manifestations. Epidemiology. Investigative techniques. Etiology Female Hemodynamics - physiology Homeostasis - physiology Humans Hypertension Hypertension - physiopathology Male Medical sciences Middle Aged Reference Values Transcranial Doppler |
| title | Dynamics of cerebral blood flow autoregulation in hypertensive patients |
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