Formation of the Androgen Receptor Transcription Complex
Androgen receptor (AR) is required for sexual differentiation and is implicated in the development of prostate cancer. Here we describe distinct functions for cofactor proteins and gene regulatory elements in the assembly of AR-mediated transcription complexes. The formation of an activation complex...
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| Veröffentlicht in: | Molecular cell 2002-03, Vol.9 (3), p.601-610 |
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| creator | Shang, Yongfeng Myers, Molly Brown, Myles |
| description | Androgen receptor (AR) is required for sexual differentiation and is implicated in the development of prostate cancer. Here we describe distinct functions for cofactor proteins and gene regulatory elements in the assembly of AR-mediated transcription complexes. The formation of an activation complex involves AR, coactivators, and RNA polymerase II recruitment to both the enhancer and promoter, whereas the formation of a repression complex involves factors bound only at the promoter and not the enhancer. These results suggest a model for the functional coordination between the promoter and enhancer in which communication between these elements is established through shared coactivators in the AR transcription complex. |
| doi_str_mv | 10.1016/S1097-2765(02)00471-9 |
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| ispartof | Molecular cell, 2002-03, Vol.9 (3), p.601-610 |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Acetyltransferases - metabolism Cell Cycle - physiology Cell Line Dihydrotestosterone - metabolism DNA-Binding Proteins - metabolism Enhancer Elements, Genetic Gene Expression Regulation Histone Acetyltransferases Humans Macromolecular Substances Models, Genetic Nuclear Receptor Coactivator 2 Promoter Regions, Genetic Receptors, Androgen - genetics Saccharomyces cerevisiae Proteins Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic |
| title | Formation of the Androgen Receptor Transcription Complex |
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