Musculoskeletal manifestations of osteomalacia and rickets
Osteomalacia (OM) is still an important metabolic bone disease with increased prevalence in certain regions of the world as well as in the urban population of elderly confined. The disease presents with a wide variety of clinical, biochemical and radiographic manifestations mimicking other musculosk...
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| Veröffentlicht in: | Best practice & research. Clinical rheumatology 2003-12, Vol.17 (6), p.1063-1080 |
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| container_title | Best practice & research. Clinical rheumatology |
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| creator | Reginato, Antonio J Coquia, Juliet Arambulo |
| description | Osteomalacia (OM) is still an important metabolic bone disease with increased prevalence in certain regions of the world as well as in the urban population of elderly confined. The disease presents with a wide variety of clinical, biochemical and radiographic manifestations mimicking other musculoskeletal disorders, including ‘osteoporosis’. In this chapter, we provide the basis for its clinical diagnosis and management. There have been significant recent advances in the understanding of vitamin D deficiency and hypophosphataemic osteomalacia, which can now assist clinicians in the precise diagnosis and treatment of this disease. In this chapter we also review the various underlying aetiologies. The successful management of OM depends on the underlying aetiology. |
| doi_str_mv | 10.1016/j.berh.2003.09.004 |
| format | Article |
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The disease presents with a wide variety of clinical, biochemical and radiographic manifestations mimicking other musculoskeletal disorders, including ‘osteoporosis’. In this chapter, we provide the basis for its clinical diagnosis and management. There have been significant recent advances in the understanding of vitamin D deficiency and hypophosphataemic osteomalacia, which can now assist clinicians in the precise diagnosis and treatment of this disease. In this chapter we also review the various underlying aetiologies. 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The successful management of OM depends on the underlying aetiology.</description><subject>Humans</subject><subject>hypophosphataemia</subject><subject>hypovitaminosis D</subject><subject>oncogenic osteomalacia</subject><subject>osteomalacia</subject><subject>Osteomalacia - complications</subject><subject>Osteomalacia - diagnosis</subject><subject>Osteomalacia - therapy</subject><subject>rickets</subject><subject>Rickets - complications</subject><subject>Rickets - diagnosis</subject><subject>Rickets - therapy</subject><issn>1521-6942</issn><issn>1532-1770</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMorq7-AQ_Sk7fWfDaNeJHFL1jxoueQJlPMbtto0gr-e1t2wZunmcPzvsw8CF0QXBBMyutNUUP8KCjGrMCqwJgfoBMiGM2JlPhw3inJS8XpAp2mtJk4pig_RgsiCGVYkBN08zImO7YhbaGFwbRZZ3rfQBrM4EOfstBkIQ0QOtMa601mepdFb7cwpDN01Jg2wfl-LtH7w_3b6ilfvz4-r-7WuWWCDrki0llTlq7hti6p4iBrLoysHRhhKgJSsKoq56mkqIBzwritGlY1jitbsiW62vV-xvA1TqfpzicLbWt6CGPSkgjJpMATSHegjSGlCI3-jL4z8UcTrGdjeqNnY3o2prHSk7EpdLlvH-sO3F9kr2gCbncATD9-e4g6WQ-9Becj2EG74P_r_wWWmHyb</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Reginato, Antonio J</creator><creator>Coquia, Juliet Arambulo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031201</creationdate><title>Musculoskeletal manifestations of osteomalacia and rickets</title><author>Reginato, Antonio J ; Coquia, Juliet Arambulo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-917dca66df4cb6294e7b45a7bdea5a81e7538861e759758e44134c8f38fd49c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Humans</topic><topic>hypophosphataemia</topic><topic>hypovitaminosis D</topic><topic>oncogenic osteomalacia</topic><topic>osteomalacia</topic><topic>Osteomalacia - complications</topic><topic>Osteomalacia - diagnosis</topic><topic>Osteomalacia - therapy</topic><topic>rickets</topic><topic>Rickets - complications</topic><topic>Rickets - diagnosis</topic><topic>Rickets - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reginato, Antonio J</creatorcontrib><creatorcontrib>Coquia, Juliet Arambulo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Best practice & research. 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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Humans hypophosphataemia hypovitaminosis D oncogenic osteomalacia osteomalacia Osteomalacia - complications Osteomalacia - diagnosis Osteomalacia - therapy rickets Rickets - complications Rickets - diagnosis Rickets - therapy |
| title | Musculoskeletal manifestations of osteomalacia and rickets |
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