Chromosomal instability
PURPOSE OF REVIEWThis review discusses numerical and structural chromosomal instability in cancer cells and its possible etiologies, highlighting the recent literature. RECENT FINDINGSDefects in chromosomal segregation, telomere stability, and the DNA damage response play significant roles in chromo...
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| Veröffentlicht in: | Current opinion in oncology 2004-01, Vol.16 (1), p.25-31 |
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| container_title | Current opinion in oncology |
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| creator | Gollin, Susanne M |
| description | PURPOSE OF REVIEWThis review discusses numerical and structural chromosomal instability in cancer cells and its possible etiologies, highlighting the recent literature.
RECENT FINDINGSDefects in chromosomal segregation, telomere stability, and the DNA damage response play significant roles in chromosomal instability in cancer.
SUMMARYThe pace of discoveries into the biologic basis of chromosomal instability in cancer cells is quickening and the various causes, previously thought to be unrelated, are being found to be intertwined. Because chromosomal instability is likely to be a main mechanism behind tumor evasion of therapy, understanding the causes and their implications for diagnostic and prognostic evaluation and therapy is of tantamount importance. |
| doi_str_mv | 10.1097/00001622-200401000-00006 |
| format | Article |
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RECENT FINDINGSDefects in chromosomal segregation, telomere stability, and the DNA damage response play significant roles in chromosomal instability in cancer.
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RECENT FINDINGSDefects in chromosomal segregation, telomere stability, and the DNA damage response play significant roles in chromosomal instability in cancer.
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| fulltext | fulltext |
| identifier | ISSN: 1040-8746 |
| ispartof | Current opinion in oncology, 2004-01, Vol.16 (1), p.25-31 |
| issn | 1040-8746 1531-703X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Cell Transformation, Neoplastic Chromosomal Instability DNA Damage DNA Repair Humans Neoplasms - etiology Neoplasms - genetics Telomere - genetics Telomere - physiology |
| title | Chromosomal instability |
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