CagA-positive cytotoxic H. pylori strains as a link between plaque instability and atherosclerotic stroke
Aims Previous studies suggested an association between infection by cytotoxic CagA-positive Helicobacter pylori strains and atherosclerotic stroke. It has been hypothesized that CagA strains could increase the risk for stroke by affecting carotid plaque irregularity. Our aims were: (1) to confirm th...
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| Veröffentlicht in: | European heart journal 2004-01, Vol.25 (1), p.64-68 |
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| creator | Gabrielli, Maurizio Santoliquido, Angelo Cremonini, Filippo Cicconi, Valerio Candelli, Marcello Serricchio, Michele Tondi, Paolo Pola, Roberto Gasbarrini, Giovanni Pola, Paolo Gasbarrini, Antonio |
| description | Aims Previous studies suggested an association between infection by cytotoxic CagA-positive Helicobacter pylori strains and atherosclerotic stroke. It has been hypothesized that CagA strains could increase the risk for stroke by affecting carotid plaque irregularity. Our aims were: (1) to confirm the association between CagA strains and atherosclerotic stroke, and (2) to assess the association between CagA strains and carotid plaque irregularity. Methods and results We enrolled 105 consecutive patients affected by atherosclerotic stroke and 130 sex, age, social background-matched controls without relevant vascular diseases. Risk factors for atherosclerotic stroke, H. pylori infection and CagA status were evaluated in all subjects. The presence of plaque instability was evaluated by colour Doppler ultrasound. The prevalence of CagA-positive strains was significantly higher in patients than in controls (adjusted OR 2.99, 95% CI 1.52–5.88, P=0.002). The CagA seropositivity was the only factor independently associated with carotid plaque irregularity (adjusted OR 8.42, 95% CI 1.58–44.64, P=0.004). Conclusion The evidence of significant associations between CagA-positive H. pylori strains and the presence of carotid plaque instability support their possibleinvolvement in the pathophysiology of atherosclerotic stroke. |
| doi_str_mv | 10.1016/j.ehj.2003.10.004 |
| format | Article |
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It has been hypothesized that CagA strains could increase the risk for stroke by affecting carotid plaque irregularity. Our aims were: (1) to confirm the association between CagA strains and atherosclerotic stroke, and (2) to assess the association between CagA strains and carotid plaque irregularity. Methods and results We enrolled 105 consecutive patients affected by atherosclerotic stroke and 130 sex, age, social background-matched controls without relevant vascular diseases. Risk factors for atherosclerotic stroke, H. pylori infection and CagA status were evaluated in all subjects. The presence of plaque instability was evaluated by colour Doppler ultrasound. The prevalence of CagA-positive strains was significantly higher in patients than in controls (adjusted OR 2.99, 95% CI 1.52–5.88, P=0.002). The CagA seropositivity was the only factor independently associated with carotid plaque irregularity (adjusted OR 8.42, 95% CI 1.58–44.64, P=0.004). Conclusion The evidence of significant associations between CagA-positive H. pylori strains and the presence of carotid plaque instability support their possibleinvolvement in the pathophysiology of atherosclerotic stroke.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1016/j.ehj.2003.10.004</identifier><identifier>PMID: 14683744</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aged ; Antigens, Bacterial - analysis ; Arteriosclerosis - diagnostic imaging ; Arteriosclerosis - microbiology ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Bacterial Proteins - analysis ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - microbiology ; Case-Control Studies ; Epidemiology andprevention ; Female ; Helicobacter Infections - complications ; Helicobacter pylori ; Humans ; Male ; Medical sciences ; Neurology ; Odds Ratio ; Risk Factors ; Stroke ; Stroke - microbiology ; Ultrasonography, Doppler, Color ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>European heart journal, 2004-01, Vol.25 (1), p.64-68</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Jan 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-ee372f9669f8222c68fe7244ab6c1e100c651af0f4b1bad12d048c4542208cdf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15481007$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14683744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gabrielli, Maurizio</creatorcontrib><creatorcontrib>Santoliquido, Angelo</creatorcontrib><creatorcontrib>Cremonini, Filippo</creatorcontrib><creatorcontrib>Cicconi, Valerio</creatorcontrib><creatorcontrib>Candelli, Marcello</creatorcontrib><creatorcontrib>Serricchio, Michele</creatorcontrib><creatorcontrib>Tondi, Paolo</creatorcontrib><creatorcontrib>Pola, Roberto</creatorcontrib><creatorcontrib>Gasbarrini, Giovanni</creatorcontrib><creatorcontrib>Pola, Paolo</creatorcontrib><creatorcontrib>Gasbarrini, Antonio</creatorcontrib><title>CagA-positive cytotoxic H. pylori strains as a link between plaque instability and atherosclerotic stroke</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Aims Previous studies suggested an association between infection by cytotoxic CagA-positive Helicobacter pylori strains and atherosclerotic stroke. It has been hypothesized that CagA strains could increase the risk for stroke by affecting carotid plaque irregularity. Our aims were: (1) to confirm the association between CagA strains and atherosclerotic stroke, and (2) to assess the association between CagA strains and carotid plaque irregularity. Methods and results We enrolled 105 consecutive patients affected by atherosclerotic stroke and 130 sex, age, social background-matched controls without relevant vascular diseases. Risk factors for atherosclerotic stroke, H. pylori infection and CagA status were evaluated in all subjects. The presence of plaque instability was evaluated by colour Doppler ultrasound. The prevalence of CagA-positive strains was significantly higher in patients than in controls (adjusted OR 2.99, 95% CI 1.52–5.88, P=0.002). The CagA seropositivity was the only factor independently associated with carotid plaque irregularity (adjusted OR 8.42, 95% CI 1.58–44.64, P=0.004). Conclusion The evidence of significant associations between CagA-positive H. pylori strains and the presence of carotid plaque instability support their possibleinvolvement in the pathophysiology of atherosclerotic stroke.</description><subject>Aged</subject><subject>Antigens, Bacterial - analysis</subject><subject>Arteriosclerosis - diagnostic imaging</subject><subject>Arteriosclerosis - microbiology</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Bacterial Proteins - analysis</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - microbiology</subject><subject>Case-Control Studies</subject><subject>Epidemiology andprevention</subject><subject>Female</subject><subject>Helicobacter Infections - complications</subject><subject>Helicobacter pylori</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Odds Ratio</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Stroke - microbiology</subject><subject>Ultrasonography, Doppler, Color</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkVFv0zAQxy3ExLrBB-AFWUjbW8LZsR3ncaoYRergARATL5bjOMxpGgfbhfXb46oVk5Css-z73V9390foNYGSABHvhtI-DCUFqPK7BGDP0IJwSotGMP4cLYA0vBBC3p-jixgHAJCCiBfonDAhq5qxBXJL_fOmmH10yf222OyTT_7RGbwq8bwffXA4pqDdFLHOB49u2uDWpj_WTnge9a-dxTmZdOtGl_ZYTx3W6cEGH82YY8pSWcBv7Et01usx2len-xJ9u33_dbkq1p8_fFzerAvDgaTC2qqmfSNE00tKqRGytzVlTLfCEEsAjOBE99CzlrS6I7QDJg3jjFKQpuurS3R91J2Dz93FpLYuGjuOerJ-F1VNeE0EhQy-_Q8c_C5MuTdFCWdNA1RmiBwhkyeKwfZqDm6rw14RUAcT1KCyCepgwuErm5Br3pyEd-3Wdk8Vp61n4OoE6Gj02Ac9GRefOM5kHrTOXHHkXEz28V9eh40SdVVztbr_ocT6yycpvt-pVfUXsLqgJw</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Gabrielli, Maurizio</creator><creator>Santoliquido, Angelo</creator><creator>Cremonini, Filippo</creator><creator>Cicconi, Valerio</creator><creator>Candelli, Marcello</creator><creator>Serricchio, Michele</creator><creator>Tondi, Paolo</creator><creator>Pola, Roberto</creator><creator>Gasbarrini, Giovanni</creator><creator>Pola, Paolo</creator><creator>Gasbarrini, Antonio</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>CagA-positive cytotoxic H. pylori strains as a link between plaque instability and atherosclerotic stroke</title><author>Gabrielli, Maurizio ; Santoliquido, Angelo ; Cremonini, Filippo ; Cicconi, Valerio ; Candelli, Marcello ; Serricchio, Michele ; Tondi, Paolo ; Pola, Roberto ; Gasbarrini, Giovanni ; Pola, Paolo ; Gasbarrini, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-ee372f9669f8222c68fe7244ab6c1e100c651af0f4b1bad12d048c4542208cdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Antigens, Bacterial - analysis</topic><topic>Arteriosclerosis - diagnostic imaging</topic><topic>Arteriosclerosis - microbiology</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Bacterial Proteins - analysis</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - microbiology</topic><topic>Case-Control Studies</topic><topic>Epidemiology andprevention</topic><topic>Female</topic><topic>Helicobacter Infections - complications</topic><topic>Helicobacter pylori</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Odds Ratio</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Stroke - microbiology</topic><topic>Ultrasonography, Doppler, Color</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gabrielli, Maurizio</creatorcontrib><creatorcontrib>Santoliquido, Angelo</creatorcontrib><creatorcontrib>Cremonini, Filippo</creatorcontrib><creatorcontrib>Cicconi, Valerio</creatorcontrib><creatorcontrib>Candelli, Marcello</creatorcontrib><creatorcontrib>Serricchio, Michele</creatorcontrib><creatorcontrib>Tondi, Paolo</creatorcontrib><creatorcontrib>Pola, Roberto</creatorcontrib><creatorcontrib>Gasbarrini, Giovanni</creatorcontrib><creatorcontrib>Pola, Paolo</creatorcontrib><creatorcontrib>Gasbarrini, Antonio</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gabrielli, Maurizio</au><au>Santoliquido, Angelo</au><au>Cremonini, Filippo</au><au>Cicconi, Valerio</au><au>Candelli, Marcello</au><au>Serricchio, Michele</au><au>Tondi, Paolo</au><au>Pola, Roberto</au><au>Gasbarrini, Giovanni</au><au>Pola, Paolo</au><au>Gasbarrini, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CagA-positive cytotoxic H. pylori strains as a link between plaque instability and atherosclerotic stroke</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>25</volume><issue>1</issue><spage>64</spage><epage>68</epage><pages>64-68</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims Previous studies suggested an association between infection by cytotoxic CagA-positive Helicobacter pylori strains and atherosclerotic stroke. It has been hypothesized that CagA strains could increase the risk for stroke by affecting carotid plaque irregularity. Our aims were: (1) to confirm the association between CagA strains and atherosclerotic stroke, and (2) to assess the association between CagA strains and carotid plaque irregularity. Methods and results We enrolled 105 consecutive patients affected by atherosclerotic stroke and 130 sex, age, social background-matched controls without relevant vascular diseases. Risk factors for atherosclerotic stroke, H. pylori infection and CagA status were evaluated in all subjects. The presence of plaque instability was evaluated by colour Doppler ultrasound. The prevalence of CagA-positive strains was significantly higher in patients than in controls (adjusted OR 2.99, 95% CI 1.52–5.88, P=0.002). The CagA seropositivity was the only factor independently associated with carotid plaque irregularity (adjusted OR 8.42, 95% CI 1.58–44.64, P=0.004). Conclusion The evidence of significant associations between CagA-positive H. pylori strains and the presence of carotid plaque instability support their possibleinvolvement in the pathophysiology of atherosclerotic stroke.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>14683744</pmid><doi>10.1016/j.ehj.2003.10.004</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Antigens, Bacterial - analysis Arteriosclerosis - diagnostic imaging Arteriosclerosis - microbiology Atherosclerosis Atherosclerosis (general aspects, experimental research) Bacterial Proteins - analysis Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - microbiology Case-Control Studies Epidemiology andprevention Female Helicobacter Infections - complications Helicobacter pylori Humans Male Medical sciences Neurology Odds Ratio Risk Factors Stroke Stroke - microbiology Ultrasonography, Doppler, Color Vascular diseases and vascular malformations of the nervous system |
| title | CagA-positive cytotoxic H. pylori strains as a link between plaque instability and atherosclerotic stroke |
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