Cellular responses of bioabsorbable polymeric material and guglielmi detachable coil in experimental aneurysms
Acceleration of healing mechanisms is a promising approach to improve current limitations of endovascular aneurysm therapy with the use of platinum coils. We evaluated a new endovascular therapeutic, bioabsorbable polymeric material (BPM), which may promote cellular reaction in the aneurysms. Four d...
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| Veröffentlicht in: | Stroke (1970) 2002-04, Vol.33 (4), p.1120-1128 |
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| container_title | Stroke (1970) |
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| creator | MURAYAMA, Yuichi VINUELA, Fernando TATESHIMA, Satoshi GONZALEZ, Nestor R SONG, Joon K MAHDAVIEH, Haleh IRUELA-ARISPE, Luisa |
| description | Acceleration of healing mechanisms is a promising approach to improve current limitations of endovascular aneurysm therapy with the use of platinum coils. We evaluated a new endovascular therapeutic, bioabsorbable polymeric material (BPM), which may promote cellular reaction in the aneurysms.
Four different concentrations of lactide/glycolic acid copolymer [poly(D-L-lactic-co-glycolic acid)] (PLGA), 85/15, 75/25, 65/35, and 50/50, were used as BPMs. Sixteen experimental aneurysms were created in 8 swine. Eight-millimeter-long spiral-shaped BPMs were surgically implanted in the aneurysms without tight packing (n=3 for each BPM). Guglielmi detachable coils (GDCs) were used as control (n=4). The animals were killed 14 days after embolization, and angiographic, histological, and immunohistochemical analyses were performed.
Despite loose packing of aneurysms with BPMs, faster BPMs such as 50/50 or 65/35 PLGA demonstrated more mature collagen formation and fibrosis in the sac and neck of the aneurysm. One aneurysm treated with 65/35 PLGA, 1 treated with 75/25 PLGA, and all 3 treated with 85/15 PLGA showed a neck remnant on angiography. There was a linear relationship between collagen levels and polymer degradation properties (r=-0.9513).
This preliminary animal study indicates that acceleration of aneurysm healing with the use of BPM is feasible. This concept can be applied to decrease and perhaps prevent aneurysmal recanalization after endovascular treatment of cerebral aneurysms. |
| doi_str_mv | 10.1161/01.STR.0000014423.20476.EE |
| format | Article |
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Four different concentrations of lactide/glycolic acid copolymer [poly(D-L-lactic-co-glycolic acid)] (PLGA), 85/15, 75/25, 65/35, and 50/50, were used as BPMs. Sixteen experimental aneurysms were created in 8 swine. Eight-millimeter-long spiral-shaped BPMs were surgically implanted in the aneurysms without tight packing (n=3 for each BPM). Guglielmi detachable coils (GDCs) were used as control (n=4). The animals were killed 14 days after embolization, and angiographic, histological, and immunohistochemical analyses were performed.
Despite loose packing of aneurysms with BPMs, faster BPMs such as 50/50 or 65/35 PLGA demonstrated more mature collagen formation and fibrosis in the sac and neck of the aneurysm. One aneurysm treated with 65/35 PLGA, 1 treated with 75/25 PLGA, and all 3 treated with 85/15 PLGA showed a neck remnant on angiography. There was a linear relationship between collagen levels and polymer degradation properties (r=-0.9513).
This preliminary animal study indicates that acceleration of aneurysm healing with the use of BPM is feasible. This concept can be applied to decrease and perhaps prevent aneurysmal recanalization after endovascular treatment of cerebral aneurysms.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.0000014423.20476.EE</identifier><identifier>PMID: 11935070</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Absorbable Implants - adverse effects ; Aneurysm - complications ; Aneurysm - diagnostic imaging ; Aneurysm - surgery ; Angiography ; Animals ; Biocompatible Materials - chemistry ; Biocompatible Materials - pharmacology ; Biological and medical sciences ; Blood Vessel Prosthesis - adverse effects ; Blood Vessel Prosthesis Implantation - methods ; Carotid Artery Diseases - complications ; Carotid Artery Diseases - pathology ; Carotid Artery Diseases - surgery ; Carotid Artery, Common - metabolism ; Carotid Artery, Common - pathology ; Carotid Artery, Common - surgery ; Collagen Type I - metabolism ; Disease Models, Animal ; Diseases of the nervous system ; Embolization, Therapeutic - instrumentation ; Embolization, Therapeutic - methods ; Feasibility Studies ; Female ; Fibrosis - etiology ; Foreign-Body Reaction - etiology ; Immunohistochemistry ; Implants, Experimental - adverse effects ; Lactic Acid - chemistry ; Lactic Acid - pharmacology ; Male ; Medical sciences ; Polyglycolic Acid - chemistry ; Polyglycolic Acid - pharmacology ; Polylactic Acid-Polyglycolic Acid Copolymer ; Polymers - chemistry ; Polymers - pharmacology ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Swine ; Thrombosis - etiology ; Wound Healing - drug effects</subject><ispartof>Stroke (1970), 2002-04, Vol.33 (4), p.1120-1128</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Apr 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-c9c0d95ed20703477cb535ab794df9fe285887d225a1faa3cd69b7c5aaa8c30f3</citedby><cites>FETCH-LOGICAL-c583t-c9c0d95ed20703477cb535ab794df9fe285887d225a1faa3cd69b7c5aaa8c30f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13596697$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11935070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MURAYAMA, Yuichi</creatorcontrib><creatorcontrib>VINUELA, Fernando</creatorcontrib><creatorcontrib>TATESHIMA, Satoshi</creatorcontrib><creatorcontrib>GONZALEZ, Nestor R</creatorcontrib><creatorcontrib>SONG, Joon K</creatorcontrib><creatorcontrib>MAHDAVIEH, Haleh</creatorcontrib><creatorcontrib>IRUELA-ARISPE, Luisa</creatorcontrib><title>Cellular responses of bioabsorbable polymeric material and guglielmi detachable coil in experimental aneurysms</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Acceleration of healing mechanisms is a promising approach to improve current limitations of endovascular aneurysm therapy with the use of platinum coils. We evaluated a new endovascular therapeutic, bioabsorbable polymeric material (BPM), which may promote cellular reaction in the aneurysms.
Four different concentrations of lactide/glycolic acid copolymer [poly(D-L-lactic-co-glycolic acid)] (PLGA), 85/15, 75/25, 65/35, and 50/50, were used as BPMs. Sixteen experimental aneurysms were created in 8 swine. Eight-millimeter-long spiral-shaped BPMs were surgically implanted in the aneurysms without tight packing (n=3 for each BPM). Guglielmi detachable coils (GDCs) were used as control (n=4). The animals were killed 14 days after embolization, and angiographic, histological, and immunohistochemical analyses were performed.
Despite loose packing of aneurysms with BPMs, faster BPMs such as 50/50 or 65/35 PLGA demonstrated more mature collagen formation and fibrosis in the sac and neck of the aneurysm. One aneurysm treated with 65/35 PLGA, 1 treated with 75/25 PLGA, and all 3 treated with 85/15 PLGA showed a neck remnant on angiography. There was a linear relationship between collagen levels and polymer degradation properties (r=-0.9513).
This preliminary animal study indicates that acceleration of aneurysm healing with the use of BPM is feasible. This concept can be applied to decrease and perhaps prevent aneurysmal recanalization after endovascular treatment of cerebral aneurysms.</description><subject>Absorbable Implants - adverse effects</subject><subject>Aneurysm - complications</subject><subject>Aneurysm - diagnostic imaging</subject><subject>Aneurysm - surgery</subject><subject>Angiography</subject><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood Vessel Prosthesis - adverse effects</subject><subject>Blood Vessel Prosthesis Implantation - methods</subject><subject>Carotid Artery Diseases - complications</subject><subject>Carotid Artery Diseases - pathology</subject><subject>Carotid Artery Diseases - surgery</subject><subject>Carotid Artery, Common - metabolism</subject><subject>Carotid Artery, Common - pathology</subject><subject>Carotid Artery, Common - surgery</subject><subject>Collagen Type I - metabolism</subject><subject>Disease Models, Animal</subject><subject>Diseases of the nervous system</subject><subject>Embolization, Therapeutic - instrumentation</subject><subject>Embolization, Therapeutic - methods</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fibrosis - etiology</subject><subject>Foreign-Body Reaction - etiology</subject><subject>Immunohistochemistry</subject><subject>Implants, Experimental - adverse effects</subject><subject>Lactic Acid - chemistry</subject><subject>Lactic Acid - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Polyglycolic Acid - pharmacology</subject><subject>Polylactic Acid-Polyglycolic Acid Copolymer</subject><subject>Polymers - chemistry</subject><subject>Polymers - pharmacology</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Swine</subject><subject>Thrombosis - etiology</subject><subject>Wound Healing - drug effects</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0V1L5DAUBuAgKzqr_gUJwnrXmo-mabyToe4KguDHdThNU62kTU1a2Pn3G2cGBjY35-Y5J-fwInRFSU5pSW8IzV9en3Py_WhRMJ4zUsgyr-sjtKKCFVlRsuoHWhHCVcYKpU7Rzxg_E2e8EifolFLFBZFkhca1dW5xEHCwcfJjtBH7Dje9hyb60EDjLJ682ww29AYPMKcKDsPY4vfl3fXWDT1u7QzmY2uN7x3uR2z_TkkOdpy32i5hE4d4jo47cNFe7OsZeruvX9d_ssen3w_ru8fMiIrPmVGGtErYlqUleSGlaQQX0EhVtJ3qLKtEVcmWMQG0A-CmLVUjjQCAynDS8TN0vZs7Bf-12DjroY8mnZo28UvUkgpJiVQJXv0HP_0SxrSbpkrKSghWJnS7Qyb4GIPt9JROg7DRlOjvSDShOkWiD5HobSS6rlPz5f6HpRlse2jdZ5DArz2AaMB1AUbTx4PjQpWlkvwfpW2XMg</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>MURAYAMA, Yuichi</creator><creator>VINUELA, Fernando</creator><creator>TATESHIMA, Satoshi</creator><creator>GONZALEZ, Nestor R</creator><creator>SONG, Joon K</creator><creator>MAHDAVIEH, Haleh</creator><creator>IRUELA-ARISPE, Luisa</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Cellular responses of bioabsorbable polymeric material and guglielmi detachable coil in experimental aneurysms</title><author>MURAYAMA, Yuichi ; VINUELA, Fernando ; TATESHIMA, Satoshi ; GONZALEZ, Nestor R ; SONG, Joon K ; MAHDAVIEH, Haleh ; IRUELA-ARISPE, Luisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-c9c0d95ed20703477cb535ab794df9fe285887d225a1faa3cd69b7c5aaa8c30f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Absorbable Implants - adverse effects</topic><topic>Aneurysm - complications</topic><topic>Aneurysm - diagnostic imaging</topic><topic>Aneurysm - surgery</topic><topic>Angiography</topic><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood Vessel Prosthesis - adverse effects</topic><topic>Blood Vessel Prosthesis Implantation - methods</topic><topic>Carotid Artery Diseases - complications</topic><topic>Carotid Artery Diseases - pathology</topic><topic>Carotid Artery Diseases - surgery</topic><topic>Carotid Artery, Common - metabolism</topic><topic>Carotid Artery, Common - pathology</topic><topic>Carotid Artery, Common - surgery</topic><topic>Collagen Type I - metabolism</topic><topic>Disease Models, Animal</topic><topic>Diseases of the nervous system</topic><topic>Embolization, Therapeutic - instrumentation</topic><topic>Embolization, Therapeutic - methods</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Fibrosis - etiology</topic><topic>Foreign-Body Reaction - etiology</topic><topic>Immunohistochemistry</topic><topic>Implants, Experimental - adverse effects</topic><topic>Lactic Acid - chemistry</topic><topic>Lactic Acid - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Polyglycolic Acid - pharmacology</topic><topic>Polylactic Acid-Polyglycolic Acid Copolymer</topic><topic>Polymers - chemistry</topic><topic>Polymers - pharmacology</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Swine</topic><topic>Thrombosis - etiology</topic><topic>Wound Healing - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MURAYAMA, Yuichi</creatorcontrib><creatorcontrib>VINUELA, Fernando</creatorcontrib><creatorcontrib>TATESHIMA, Satoshi</creatorcontrib><creatorcontrib>GONZALEZ, Nestor R</creatorcontrib><creatorcontrib>SONG, Joon K</creatorcontrib><creatorcontrib>MAHDAVIEH, Haleh</creatorcontrib><creatorcontrib>IRUELA-ARISPE, Luisa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MURAYAMA, Yuichi</au><au>VINUELA, Fernando</au><au>TATESHIMA, Satoshi</au><au>GONZALEZ, Nestor R</au><au>SONG, Joon K</au><au>MAHDAVIEH, Haleh</au><au>IRUELA-ARISPE, Luisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cellular responses of bioabsorbable polymeric material and guglielmi detachable coil in experimental aneurysms</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>33</volume><issue>4</issue><spage>1120</spage><epage>1128</epage><pages>1120-1128</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Acceleration of healing mechanisms is a promising approach to improve current limitations of endovascular aneurysm therapy with the use of platinum coils. We evaluated a new endovascular therapeutic, bioabsorbable polymeric material (BPM), which may promote cellular reaction in the aneurysms.
Four different concentrations of lactide/glycolic acid copolymer [poly(D-L-lactic-co-glycolic acid)] (PLGA), 85/15, 75/25, 65/35, and 50/50, were used as BPMs. Sixteen experimental aneurysms were created in 8 swine. Eight-millimeter-long spiral-shaped BPMs were surgically implanted in the aneurysms without tight packing (n=3 for each BPM). Guglielmi detachable coils (GDCs) were used as control (n=4). The animals were killed 14 days after embolization, and angiographic, histological, and immunohistochemical analyses were performed.
Despite loose packing of aneurysms with BPMs, faster BPMs such as 50/50 or 65/35 PLGA demonstrated more mature collagen formation and fibrosis in the sac and neck of the aneurysm. One aneurysm treated with 65/35 PLGA, 1 treated with 75/25 PLGA, and all 3 treated with 85/15 PLGA showed a neck remnant on angiography. There was a linear relationship between collagen levels and polymer degradation properties (r=-0.9513).
This preliminary animal study indicates that acceleration of aneurysm healing with the use of BPM is feasible. This concept can be applied to decrease and perhaps prevent aneurysmal recanalization after endovascular treatment of cerebral aneurysms.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11935070</pmid><doi>10.1161/01.STR.0000014423.20476.EE</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Stroke (1970), 2002-04, Vol.33 (4), p.1120-1128 |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Absorbable Implants - adverse effects Aneurysm - complications Aneurysm - diagnostic imaging Aneurysm - surgery Angiography Animals Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Biological and medical sciences Blood Vessel Prosthesis - adverse effects Blood Vessel Prosthesis Implantation - methods Carotid Artery Diseases - complications Carotid Artery Diseases - pathology Carotid Artery Diseases - surgery Carotid Artery, Common - metabolism Carotid Artery, Common - pathology Carotid Artery, Common - surgery Collagen Type I - metabolism Disease Models, Animal Diseases of the nervous system Embolization, Therapeutic - instrumentation Embolization, Therapeutic - methods Feasibility Studies Female Fibrosis - etiology Foreign-Body Reaction - etiology Immunohistochemistry Implants, Experimental - adverse effects Lactic Acid - chemistry Lactic Acid - pharmacology Male Medical sciences Polyglycolic Acid - chemistry Polyglycolic Acid - pharmacology Polylactic Acid-Polyglycolic Acid Copolymer Polymers - chemistry Polymers - pharmacology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Swine Thrombosis - etiology Wound Healing - drug effects |
| title | Cellular responses of bioabsorbable polymeric material and guglielmi detachable coil in experimental aneurysms |
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