Control of the AcrAB multidrug efflux pump by quorum‐sensing regulator SdiA
Summary SdiA is an Escherichia coli protein that regulates cell division in a cell density‐dependent, or quorum‐sensing, manner. We report that SdiA also controls multidrug resistance by positively regulating the multidrug resistance pump AcrAB. Overproduction of SdiA confers multidrug resistance an...
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| Veröffentlicht in: | Molecular microbiology 2002-02, Vol.43 (3), p.677-685 |
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| container_title | Molecular microbiology |
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| creator | Rahmati, Sonia Yang, Shirley Davidson, Amy L. Zechiedrich, E. Lynn |
| description | Summary
SdiA is an Escherichia coli protein that regulates cell division in a cell
density‐dependent, or quorum‐sensing, manner. We report that SdiA also controls multidrug
resistance by positively regulating the multidrug resistance pump AcrAB. Overproduction
of SdiA confers multidrug resistance and increased levels of AcrAB. Conversely, sdiA null mutants are hypersensitive to drugs and have decreased levels of AcrB protein. Our findings provide a link between quorum sensing and multidrug efflux. Combined with previously published reports, our data support a model in which a role of drug efflux pumps is to mediate cell–cell communication in response to cell density. Xenobiotics expelled by pumps may resemble the communication molecules that they normally efflux. |
| doi_str_mv | 10.1046/j.1365-2958.2002.02773.x |
| format | Article |
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SdiA is an Escherichia coli protein that regulates cell division in a cell
density‐dependent, or quorum‐sensing, manner. We report that SdiA also controls multidrug
resistance by positively regulating the multidrug resistance pump AcrAB. Overproduction
of SdiA confers multidrug resistance and increased levels of AcrAB. Conversely, sdiA null mutants are hypersensitive to drugs and have decreased levels of AcrB protein. Our findings provide a link between quorum sensing and multidrug efflux. Combined with previously published reports, our data support a model in which a role of drug efflux pumps is to mediate cell–cell communication in response to cell density. Xenobiotics expelled by pumps may resemble the communication molecules that they normally efflux.</description><identifier>ISSN: 0950-382X</identifier><identifier>EISSN: 1365-2958</identifier><identifier>DOI: 10.1046/j.1365-2958.2002.02773.x</identifier><identifier>PMID: 11929524</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Bacterial Proteins - drug effects ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Carrier Proteins ; Drug Resistance, Multiple, Bacterial - physiology ; Escherichia coli - drug effects ; Escherichia coli - physiology ; Escherichia coli Proteins ; Gene Expression Regulation, Bacterial ; Lipoproteins - drug effects ; Lipoproteins - genetics ; Lipoproteins - metabolism ; Membrane Proteins - drug effects ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Membrane Transport Proteins ; Multidrug Resistance-Associated Proteins ; Mutation ; Quinolones - pharmacology ; Trans-Activators - drug effects ; Trans-Activators - genetics ; Trans-Activators - metabolism</subject><ispartof>Molecular microbiology, 2002-02, Vol.43 (3), p.677-685</ispartof><rights>Copyright Blackwell Scientific Publications Ltd. Feb 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5393-6be5f172dacf2ac6e0b9b251cb975e89dde55757849c41378d6820c5d02a6b2b3</citedby><cites>FETCH-LOGICAL-c5393-6be5f172dacf2ac6e0b9b251cb975e89dde55757849c41378d6820c5d02a6b2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2958.2002.02773.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2958.2002.02773.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11929524$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahmati, Sonia</creatorcontrib><creatorcontrib>Yang, Shirley</creatorcontrib><creatorcontrib>Davidson, Amy L.</creatorcontrib><creatorcontrib>Zechiedrich, E. Lynn</creatorcontrib><title>Control of the AcrAB multidrug efflux pump by quorum‐sensing regulator SdiA</title><title>Molecular microbiology</title><addtitle>Mol Microbiol</addtitle><description>Summary
SdiA is an Escherichia coli protein that regulates cell division in a cell
density‐dependent, or quorum‐sensing, manner. We report that SdiA also controls multidrug
resistance by positively regulating the multidrug resistance pump AcrAB. Overproduction
of SdiA confers multidrug resistance and increased levels of AcrAB. Conversely, sdiA null mutants are hypersensitive to drugs and have decreased levels of AcrB protein. Our findings provide a link between quorum sensing and multidrug efflux. Combined with previously published reports, our data support a model in which a role of drug efflux pumps is to mediate cell–cell communication in response to cell density. Xenobiotics expelled by pumps may resemble the communication molecules that they normally efflux.</description><subject>Bacterial Proteins - drug effects</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Carrier Proteins</subject><subject>Drug Resistance, Multiple, Bacterial - physiology</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - physiology</subject><subject>Escherichia coli Proteins</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Lipoproteins - drug effects</subject><subject>Lipoproteins - genetics</subject><subject>Lipoproteins - metabolism</subject><subject>Membrane Proteins - drug effects</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - metabolism</subject><subject>Membrane Transport Proteins</subject><subject>Multidrug Resistance-Associated Proteins</subject><subject>Mutation</subject><subject>Quinolones - pharmacology</subject><subject>Trans-Activators - drug effects</subject><subject>Trans-Activators - genetics</subject><subject>Trans-Activators - metabolism</subject><issn>0950-382X</issn><issn>1365-2958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkb1u2zAUhYmiQe04fYWC6NBNCn9EUhwyuEaTGrCRIQmQjZAoypEgiTYpovaWR-gz9kkqxUYCdGmme4H7nQPccwCAGMUYJfyyjjHlLCKSpTFBiMSICEHj_QcwfT18BFMkGYpoSh4n4Nz7GiFMEaefwARjOSAkmYL1wna9sw20JeyfDJxrN_8O29D0VeHCBpqybMIebkO7hfkB7oJ1of3z_NubzlfdBjqzCU3WWwfvimp-Ac7KrPHm82nOwMP1j_vFz2h1e7NczFeRZlTSiOeGlViQItMlyTQ3KJc5YVjnUjCTyqIwjAkm0kTqBFORFjwlSLMCkYznJKcz8O3ou3V2F4zvVVt5bZom64wNXgnMuBQJ_S-IU8GShJAB_PoPWNvguuEJhSVnRFCcDFB6hLSz3jtTqq2r2swdFEZqLEbVasxfjfmrsRj1UozaD9IvJ_-Qt6Z4E56aGICrI_Craszh3cZqvV6OG_0LUZWcNg</recordid><startdate>200202</startdate><enddate>200202</enddate><creator>Rahmati, Sonia</creator><creator>Yang, Shirley</creator><creator>Davidson, Amy L.</creator><creator>Zechiedrich, E. 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Lynn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5393-6be5f172dacf2ac6e0b9b251cb975e89dde55757849c41378d6820c5d02a6b2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Bacterial Proteins - drug effects</topic><topic>Bacterial Proteins - genetics</topic><topic>Bacterial Proteins - metabolism</topic><topic>Carrier Proteins</topic><topic>Drug Resistance, Multiple, Bacterial - physiology</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - physiology</topic><topic>Escherichia coli Proteins</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Lipoproteins - drug effects</topic><topic>Lipoproteins - genetics</topic><topic>Lipoproteins - metabolism</topic><topic>Membrane Proteins - drug effects</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Membrane Transport Proteins</topic><topic>Multidrug Resistance-Associated Proteins</topic><topic>Mutation</topic><topic>Quinolones - pharmacology</topic><topic>Trans-Activators - drug effects</topic><topic>Trans-Activators - genetics</topic><topic>Trans-Activators - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahmati, Sonia</creatorcontrib><creatorcontrib>Yang, Shirley</creatorcontrib><creatorcontrib>Davidson, Amy L.</creatorcontrib><creatorcontrib>Zechiedrich, E. 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Lynn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of the AcrAB multidrug efflux pump by quorum‐sensing regulator SdiA</atitle><jtitle>Molecular microbiology</jtitle><addtitle>Mol Microbiol</addtitle><date>2002-02</date><risdate>2002</risdate><volume>43</volume><issue>3</issue><spage>677</spage><epage>685</epage><pages>677-685</pages><issn>0950-382X</issn><eissn>1365-2958</eissn><abstract>Summary
SdiA is an Escherichia coli protein that regulates cell division in a cell
density‐dependent, or quorum‐sensing, manner. We report that SdiA also controls multidrug
resistance by positively regulating the multidrug resistance pump AcrAB. Overproduction
of SdiA confers multidrug resistance and increased levels of AcrAB. Conversely, sdiA null mutants are hypersensitive to drugs and have decreased levels of AcrB protein. Our findings provide a link between quorum sensing and multidrug efflux. Combined with previously published reports, our data support a model in which a role of drug efflux pumps is to mediate cell–cell communication in response to cell density. Xenobiotics expelled by pumps may resemble the communication molecules that they normally efflux.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11929524</pmid><doi>10.1046/j.1365-2958.2002.02773.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Bacterial Proteins - drug effects Bacterial Proteins - genetics Bacterial Proteins - metabolism Carrier Proteins Drug Resistance, Multiple, Bacterial - physiology Escherichia coli - drug effects Escherichia coli - physiology Escherichia coli Proteins Gene Expression Regulation, Bacterial Lipoproteins - drug effects Lipoproteins - genetics Lipoproteins - metabolism Membrane Proteins - drug effects Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Transport Proteins Multidrug Resistance-Associated Proteins Mutation Quinolones - pharmacology Trans-Activators - drug effects Trans-Activators - genetics Trans-Activators - metabolism |
| title | Control of the AcrAB multidrug efflux pump by quorum‐sensing regulator SdiA |
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