Citation bias of hepato-biliary randomized clinical trials
The objective of this study was to assess whether trials with a positive (i.e., statistically significant) outcome are cited more often than negative trials. We reviewed 530 randomized clinical trials on hepato-biliary diseases published in 11 English-language journals indexed in MEDLINE from 1985–1...
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| Veröffentlicht in: | Journal of clinical epidemiology 2002-04, Vol.55 (4), p.407-410 |
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| container_title | Journal of clinical epidemiology |
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| creator | Kjaergard, Lise L. Gluud, Christian |
| description | The objective of this study was to assess whether trials with a positive (i.e., statistically significant) outcome are cited more often than negative trials. We reviewed 530 randomized clinical trials on hepato-biliary diseases published in 11 English-language journals indexed in MEDLINE from 1985–1996. From each trial, we extracted the statistical significance of the primary study outcome (positive or negative), the disease area, and methodological quality (randomization and double blinding). The number of citations during two calendar years after publication was obtained from Science Citation Index. There was a significant positive association between a statistically significant study outcome and the citation frequency (β, 0.55, 95% confidence interval, 0.39–0.72). The disease area and adequate generation of the allocation sequence were also significant predictors of the citation frequency. We concluded that positive trials are cited significantly more often than negative trials. The association was not explained by disease area or methodological quality. |
| doi_str_mv | 10.1016/S0895-4356(01)00513-3 |
| format | Article |
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We reviewed 530 randomized clinical trials on hepato-biliary diseases published in 11 English-language journals indexed in MEDLINE from 1985–1996. From each trial, we extracted the statistical significance of the primary study outcome (positive or negative), the disease area, and methodological quality (randomization and double blinding). The number of citations during two calendar years after publication was obtained from Science Citation Index. There was a significant positive association between a statistically significant study outcome and the citation frequency (β, 0.55, 95% confidence interval, 0.39–0.72). The disease area and adequate generation of the allocation sequence were also significant predictors of the citation frequency. We concluded that positive trials are cited significantly more often than negative trials. The association was not explained by disease area or methodological quality.</description><identifier>ISSN: 0895-4356</identifier><identifier>EISSN: 1878-5921</identifier><identifier>DOI: 10.1016/S0895-4356(01)00513-3</identifier><identifier>PMID: 11927210</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Bias ; Bibliometrics ; Biliary Tract Diseases ; Biological and medical sciences ; Clinical trial. Drug monitoring ; Double-Blind Method ; General pharmacology ; Humans ; Journal citation reports ; Liver Diseases ; Medical sciences ; MEDLINE ; Meta-analysis ; Pharmacology. 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We reviewed 530 randomized clinical trials on hepato-biliary diseases published in 11 English-language journals indexed in MEDLINE from 1985–1996. From each trial, we extracted the statistical significance of the primary study outcome (positive or negative), the disease area, and methodological quality (randomization and double blinding). The number of citations during two calendar years after publication was obtained from Science Citation Index. There was a significant positive association between a statistically significant study outcome and the citation frequency (β, 0.55, 95% confidence interval, 0.39–0.72). The disease area and adequate generation of the allocation sequence were also significant predictors of the citation frequency. We concluded that positive trials are cited significantly more often than negative trials. The association was not explained by disease area or methodological quality.</description><subject>Bias</subject><subject>Bibliometrics</subject><subject>Biliary Tract Diseases</subject><subject>Biological and medical sciences</subject><subject>Clinical trial. Drug monitoring</subject><subject>Double-Blind Method</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Journal citation reports</subject><subject>Liver Diseases</subject><subject>Medical sciences</subject><subject>MEDLINE</subject><subject>Meta-analysis</subject><subject>Pharmacology. Drug treatments</subject><subject>Randomized clinical trials</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Retrospective Studies</subject><subject>Science citation index</subject><subject>Systematic reviews</subject><issn>0895-4356</issn><issn>1878-5921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtO5DAQRS3EiG4enwDKBgSLDFV2HNtsEGrBzEgtsQDWlmM7wiidNHZ6pJmvx_0QLFnVos6txyHkFOEnAtbXTyAVLyvG60vAKwCOrGR7ZIpSyJIrivtk-olMyGFKbwAoQPADMkFUVFCEKbmZhdGMYeiLJphUDG3x6pdmHMomdMHEf0U0vRsW4b93he1CH6zpijEG06Vj8qPNxZ_s6hF5ebh_nv0u54-__szu5qWtKjaWiNyDYBWTtayYUxWlDJiRrEVwdW4aq1oHggJWtbI1tYrKphXQeNmAd-yIXGznLuPwvvJp1IuQrO860_thlbRAXismWQb5FrRxSCn6Vi9jWOQnNIJeS9MbaXptRAPqjTS9zp3tFqyahXdfqZ2lDJzvAJPy_212YkP64hgXqhY0c7dbzmcdf4OPOtnge-tdiN6O2g3hm1M-APJPhw0</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Kjaergard, Lise L.</creator><creator>Gluud, Christian</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Citation bias of hepato-biliary randomized clinical trials</title><author>Kjaergard, Lise L. ; Gluud, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-115e0734386843d9422303a83f10d615eac9fd07201469c62c928bf70be8b0ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Bias</topic><topic>Bibliometrics</topic><topic>Biliary Tract Diseases</topic><topic>Biological and medical sciences</topic><topic>Clinical trial. Drug monitoring</topic><topic>Double-Blind Method</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Journal citation reports</topic><topic>Liver Diseases</topic><topic>Medical sciences</topic><topic>MEDLINE</topic><topic>Meta-analysis</topic><topic>Pharmacology. Drug treatments</topic><topic>Randomized clinical trials</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Retrospective Studies</topic><topic>Science citation index</topic><topic>Systematic reviews</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kjaergard, Lise L.</creatorcontrib><creatorcontrib>Gluud, Christian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kjaergard, Lise L.</au><au>Gluud, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Citation bias of hepato-biliary randomized clinical trials</atitle><jtitle>Journal of clinical epidemiology</jtitle><addtitle>J Clin Epidemiol</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>55</volume><issue>4</issue><spage>407</spage><epage>410</epage><pages>407-410</pages><issn>0895-4356</issn><eissn>1878-5921</eissn><abstract>The objective of this study was to assess whether trials with a positive (i.e., statistically significant) outcome are cited more often than negative trials. We reviewed 530 randomized clinical trials on hepato-biliary diseases published in 11 English-language journals indexed in MEDLINE from 1985–1996. From each trial, we extracted the statistical significance of the primary study outcome (positive or negative), the disease area, and methodological quality (randomization and double blinding). The number of citations during two calendar years after publication was obtained from Science Citation Index. There was a significant positive association between a statistically significant study outcome and the citation frequency (β, 0.55, 95% confidence interval, 0.39–0.72). The disease area and adequate generation of the allocation sequence were also significant predictors of the citation frequency. We concluded that positive trials are cited significantly more often than negative trials. The association was not explained by disease area or methodological quality.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11927210</pmid><doi>10.1016/S0895-4356(01)00513-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of clinical epidemiology, 2002-04, Vol.55 (4), p.407-410 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Bias Bibliometrics Biliary Tract Diseases Biological and medical sciences Clinical trial. Drug monitoring Double-Blind Method General pharmacology Humans Journal citation reports Liver Diseases Medical sciences MEDLINE Meta-analysis Pharmacology. Drug treatments Randomized clinical trials Randomized Controlled Trials as Topic Retrospective Studies Science citation index Systematic reviews |
| title | Citation bias of hepato-biliary randomized clinical trials |
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