Cytokine secretion by peripheral blood mononuclear cells in myasthenia gravis
We studied spontaneous secretion of anti-acetylcholine receptor antibody (AChRAb), IgG and cytokines by peripheral blood mononuclear cells (PBMC) from 19 MG patients without therapy and 10 normal controls. IgG secretion was higher in the culture medium of MG than in that of normal controls. AChRAb s...
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| Veröffentlicht in: | Journal of clinical neuroscience 2002-03, Vol.9 (2), p.133-136 |
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| container_title | Journal of clinical neuroscience |
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| creator | Yoshikawa, Hiroaki Satoh, Katsuaki Yasukawa, Yoshihiro Yamada, Masahito |
| description | We studied spontaneous secretion of anti-acetylcholine receptor antibody (AChRAb), IgG and cytokines by peripheral blood mononuclear cells (PBMC) from 19 MG patients without therapy and 10 normal controls. IgG secretion was higher in the culture medium of MG than in that of normal controls. AChRAb secretion was correlated with IgG secretion in MG. Interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-13, interferon (IFN)-γ and tumor necrosis factor (TNF)-α secreted by PBMC from MG patients were not different from those produced by those from normal controls. IgG secretion was, however, correlated with the secretions of IL-5 and IL-6 in MG. Spontaneous B cell activation was suspected in patients with MG. |
| doi_str_mv | 10.1054/jocn.2001.1028 |
| format | Article |
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IgG secretion was higher in the culture medium of MG than in that of normal controls. AChRAb secretion was correlated with IgG secretion in MG. Interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-13, interferon (IFN)-γ and tumor necrosis factor (TNF)-α secreted by PBMC from MG patients were not different from those produced by those from normal controls. IgG secretion was, however, correlated with the secretions of IL-5 and IL-6 in MG. Spontaneous B cell activation was suspected in patients with MG.</description><identifier>ISSN: 0967-5868</identifier><identifier>EISSN: 1532-2653</identifier><identifier>DOI: 10.1054/jocn.2001.1028</identifier><identifier>PMID: 11922699</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Cells, Cultured ; Child ; Cytokines - blood ; Cytokines - secretion ; Diseases of striated muscles. Neuromuscular diseases ; Female ; Humans ; Immunoglobulin G - blood ; Interleukin-5, Interleukin-6, IgG, acetylcholine receptor antibody, myasthenia gravis ; Leukocytes, Mononuclear - secretion ; Male ; Medical sciences ; Middle Aged ; Myasthenia Gravis - blood ; Neurology ; Receptors, Cholinergic - blood ; Statistics, Nonparametric</subject><ispartof>Journal of clinical neuroscience, 2002-03, Vol.9 (2), p.133-136</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002, Elsevier Science Ltd. 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IgG secretion was higher in the culture medium of MG than in that of normal controls. AChRAb secretion was correlated with IgG secretion in MG. Interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-13, interferon (IFN)-γ and tumor necrosis factor (TNF)-α secreted by PBMC from MG patients were not different from those produced by those from normal controls. IgG secretion was, however, correlated with the secretions of IL-5 and IL-6 in MG. Spontaneous B cell activation was suspected in patients with MG.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Child</subject><subject>Cytokines - blood</subject><subject>Cytokines - secretion</subject><subject>Diseases of striated muscles. Neuromuscular diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Interleukin-5, Interleukin-6, IgG, acetylcholine receptor antibody, myasthenia gravis</subject><subject>Leukocytes, Mononuclear - secretion</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myasthenia Gravis - blood</subject><subject>Neurology</subject><subject>Receptors, Cholinergic - blood</subject><subject>Statistics, Nonparametric</subject><issn>0967-5868</issn><issn>1532-2653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1rHDEQhkVwiM8fbUqjxun2oo-VtCrN4XyAQ5qkFtrRXCx7VzpLe4b799nlDly5GgaeeXnnIeQzZ2vOVPv1KUNaC8b4vIruA1lxJUUjtJJnZMWsNo3qdHdOLmp9YozZVrJP5JxzK4S2dkV-bQ5Tfo4JaUUoOMWcaH-gOyxx94jFD7Qfcg50zCmnPQzoCwUchkpjouPB1-kRU_T0X_GvsV6Rj1s_VLw-zUvy99v9n82P5uH395-bu4cGpGFTEwQYw03olTJ8y5G3wvZWKLBtb3Tg0gLwEFqpFYMeRI9ta4LU85vGt6aTl-TLMXdX8sse6-TGWJdaPmHeV2e40pZJO4PrIwgl11pw63Yljr4cHGduEegWgW4R6BaB88HNKXnfjxje8JOxGbg9Ab6CH7bFJ4j1jZOqs0bLmeuOHM4eXiMWVyFiAgyxIEwu5Pheh_9tbYxh</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Yoshikawa, Hiroaki</creator><creator>Satoh, Katsuaki</creator><creator>Yasukawa, Yoshihiro</creator><creator>Yamada, Masahito</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Cytokine secretion by peripheral blood mononuclear cells in myasthenia gravis</title><author>Yoshikawa, Hiroaki ; Satoh, Katsuaki ; Yasukawa, Yoshihiro ; Yamada, Masahito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-d2c7717db5571f1e1429b925c94b76d139cc1dd43650cbc2be447d360017a4783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Child</topic><topic>Cytokines - blood</topic><topic>Cytokines - secretion</topic><topic>Diseases of striated muscles. Neuromuscular diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Interleukin-5, Interleukin-6, IgG, acetylcholine receptor antibody, myasthenia gravis</topic><topic>Leukocytes, Mononuclear - secretion</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myasthenia Gravis - blood</topic><topic>Neurology</topic><topic>Receptors, Cholinergic - blood</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshikawa, Hiroaki</creatorcontrib><creatorcontrib>Satoh, Katsuaki</creatorcontrib><creatorcontrib>Yasukawa, Yoshihiro</creatorcontrib><creatorcontrib>Yamada, Masahito</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshikawa, Hiroaki</au><au>Satoh, Katsuaki</au><au>Yasukawa, Yoshihiro</au><au>Yamada, Masahito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine secretion by peripheral blood mononuclear cells in myasthenia gravis</atitle><jtitle>Journal of clinical neuroscience</jtitle><addtitle>J Clin Neurosci</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>9</volume><issue>2</issue><spage>133</spage><epage>136</epage><pages>133-136</pages><issn>0967-5868</issn><eissn>1532-2653</eissn><abstract>We studied spontaneous secretion of anti-acetylcholine receptor antibody (AChRAb), IgG and cytokines by peripheral blood mononuclear cells (PBMC) from 19 MG patients without therapy and 10 normal controls. IgG secretion was higher in the culture medium of MG than in that of normal controls. AChRAb secretion was correlated with IgG secretion in MG. Interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-13, interferon (IFN)-γ and tumor necrosis factor (TNF)-α secreted by PBMC from MG patients were not different from those produced by those from normal controls. IgG secretion was, however, correlated with the secretions of IL-5 and IL-6 in MG. Spontaneous B cell activation was suspected in patients with MG.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>11922699</pmid><doi>10.1054/jocn.2001.1028</doi><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Cells, Cultured Child Cytokines - blood Cytokines - secretion Diseases of striated muscles. Neuromuscular diseases Female Humans Immunoglobulin G - blood Interleukin-5, Interleukin-6, IgG, acetylcholine receptor antibody, myasthenia gravis Leukocytes, Mononuclear - secretion Male Medical sciences Middle Aged Myasthenia Gravis - blood Neurology Receptors, Cholinergic - blood Statistics, Nonparametric |
| title | Cytokine secretion by peripheral blood mononuclear cells in myasthenia gravis |
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