CCL16 activates an angiogenic program in vascular endothelial cells

Besides regulating leukocyte trafficking in normal and injured tissues, several chemokines may positively or negatively regulate angiogenesis. Here we report that CCL16 activates an angiogenic program in vascular endothelial cells by activating CCR1. CCL16 induces dose-dependent random and direction...

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Veröffentlicht in:	Blood 2004-01, Vol.103 (1), p.40-49
Hauptverfasser:	Strasly, Marina, Doronzo, Gabriella, Capello, Paola, Valdembri, Donatella, Arese, Marco, Mitola, Stefania, Moore, Paul, Alessandri, Giulio, Giovarelli, Mirella, Bussolino, Federico
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Movement - drug effects Chemokines, CC - pharmacology Chemokines, CXC - metabolism Chick Embryo Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - growth & development Endothelium, Vascular - metabolism Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques Intercellular Signaling Peptides and Proteins - metabolism Mitogens - pharmacology Neovascularization, Physiologic - drug effects Receptors, CCR1 Receptors, CCR2 Receptors, Chemokine - drug effects Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Recombinant Proteins - pharmacology Sarcoma, Kaposi - metabolism Sarcoma, Kaposi - pathology Vascular Endothelial Growth Factor A - pharmacology Vertebrates: blood, hematopoietic organs, reticuloendothelial system
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