CD80-mediated induction of immunostimulation in two ocular melanoma cell lines is augmented by interferon-gamma

Although the transfection of the T-cell costimulatory molecule CD80 cDNA into human tumours can augment their immunogenicity in vitro, its expression alone is ineffective in many tumour systems. We evaluated the influence of CD80 expression on the immunostimulatory activity of ocular melanoma cell l...

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Veröffentlicht in:	Melanoma research 2002-04, Vol.12 (2), p.129-138
Hauptverfasser:	Mulcahy, K A, Alexander, S, Platts, K E, Wardle, C, Sisley, K, Rennie, I G, Murray, A K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology B7-1 Antigen - physiology CD4-Positive T-Lymphocytes - immunology Cell Adhesion Molecules - metabolism Eye Neoplasms - drug therapy Eye Neoplasms - genetics Eye Neoplasms - immunology Flow Cytometry Gene Expression - physiology Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class II - immunology Humans Immunization Interferon-gamma - pharmacology Lymphocyte Activation - immunology Lymphocyte Depletion Melanoma - drug therapy Melanoma - genetics Melanoma - immunology Monocytes - immunology Transfection Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - immunology Up-Regulation
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