Feline Immunodeficiency Virus Infection Is Characterized by B7+CTLA4+ T Cell Apoptosis
The B7.1 and B7.2 costimulatory molecules on antigen-presenting cells provide second signals for regulating T cell immune responses via CD28 and cytotoxic T lymphocyte antigen 4 (CTLA4) on T cells. CD28 signals cell proliferation, whereas CTLA4 signals for anergy or apoptosis, terminating the immune...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-04, Vol.185 (8), p.1077-1093 |
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| container_title | The Journal of infectious diseases |
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| creator | Tompkins, Mary B. Bull, Marta E. Dow, Janet L. Ball, Judith M. Collisson, Ellen W. Winslow, Barbara J. Phadke, Anagha P. Vahlenkamp, Thomas W. Tompkins, Wayne A. |
| description | The B7.1 and B7.2 costimulatory molecules on antigen-presenting cells provide second signals for regulating T cell immune responses via CD28 and cytotoxic T lymphocyte antigen 4 (CTLA4) on T cells. CD28 signals cell proliferation, whereas CTLA4 signals for anergy or apoptosis, terminating the immune response. Because T cell apoptosis and immunodeficiency is a characteristic of feline immunodeficiency virus (FIV)-infected cats, it is possible that negative T cell signaling via B7 and CTLA4 may be favored in these cats. Flow cytometry revealed high percentages of CD8+ and CD4+ cells expressing B7.1, B7.2, and CTLA4 in lymph nodes of FIV-positive cats and a large fraction of CTLA4+ T cells coexpressing B7.1 and B7.2. Three-color analysis with anti-B7.1, antiB7.2, or anti-CTLA4 and TUNEL (terminal deoxynucleotidyl transferase nick-end-labeling) analysis revealed that apoptosis was a characteristic of B7.1+B7.2+CTLA4+ T cells. These data support the hypothesis that lymph node apoptosis and immune deterioration in FIV-infected cats results from chronic B7.1- and/or B7.2-CTLA4-mediated T-T interactions. |
| doi_str_mv | 10.1086/339847 |
| format | Article |
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CD28 signals cell proliferation, whereas CTLA4 signals for anergy or apoptosis, terminating the immune response. Because T cell apoptosis and immunodeficiency is a characteristic of feline immunodeficiency virus (FIV)-infected cats, it is possible that negative T cell signaling via B7 and CTLA4 may be favored in these cats. Flow cytometry revealed high percentages of CD8+ and CD4+ cells expressing B7.1, B7.2, and CTLA4 in lymph nodes of FIV-positive cats and a large fraction of CTLA4+ T cells coexpressing B7.1 and B7.2. Three-color analysis with anti-B7.1, antiB7.2, or anti-CTLA4 and TUNEL (terminal deoxynucleotidyl transferase nick-end-labeling) analysis revealed that apoptosis was a characteristic of B7.1+B7.2+CTLA4+ T cells. These data support the hypothesis that lymph node apoptosis and immune deterioration in FIV-infected cats results from chronic B7.1- and/or B7.2-CTLA4-mediated T-T interactions.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/339847</identifier><identifier>PMID: 11930318</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: University of Chicago Press</publisher><subject>Abatacept ; Animals ; Antigens, CD - analysis ; Antigens, Differentiation - analysis ; Apoptosis ; B7-1 Antigen - analysis ; B7-2 Antigen ; Biological and medical sciences ; Cats ; CTLA-4 Antigen ; Experimental viral diseases and models ; Feline Acquired Immunodeficiency Syndrome - immunology ; Immunoconjugates ; In Situ Nick-End Labeling ; Infectious diseases ; Medical sciences ; Membrane Glycoproteins - analysis ; T-Lymphocytes - physiology ; Viral diseases</subject><ispartof>The Journal of infectious diseases, 2002-04, Vol.185 (8), p.1077-1093</ispartof><rights>2002 by the Infectious Diseases Society of America 2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Apr 15, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-572ad0c392ff4d3fa87c6d105c3afec0d2423d75a1acdcdd1bbcaec453ad6cd03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13624388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11930318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tompkins, Mary B.</creatorcontrib><creatorcontrib>Bull, Marta E.</creatorcontrib><creatorcontrib>Dow, Janet L.</creatorcontrib><creatorcontrib>Ball, Judith M.</creatorcontrib><creatorcontrib>Collisson, Ellen W.</creatorcontrib><creatorcontrib>Winslow, Barbara J.</creatorcontrib><creatorcontrib>Phadke, Anagha P.</creatorcontrib><creatorcontrib>Vahlenkamp, Thomas W.</creatorcontrib><creatorcontrib>Tompkins, Wayne A.</creatorcontrib><title>Feline Immunodeficiency Virus Infection Is Characterized by B7+CTLA4+ T Cell Apoptosis</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>The B7.1 and B7.2 costimulatory molecules on antigen-presenting cells provide second signals for regulating T cell immune responses via CD28 and cytotoxic T lymphocyte antigen 4 (CTLA4) on T cells. CD28 signals cell proliferation, whereas CTLA4 signals for anergy or apoptosis, terminating the immune response. Because T cell apoptosis and immunodeficiency is a characteristic of feline immunodeficiency virus (FIV)-infected cats, it is possible that negative T cell signaling via B7 and CTLA4 may be favored in these cats. Flow cytometry revealed high percentages of CD8+ and CD4+ cells expressing B7.1, B7.2, and CTLA4 in lymph nodes of FIV-positive cats and a large fraction of CTLA4+ T cells coexpressing B7.1 and B7.2. Three-color analysis with anti-B7.1, antiB7.2, or anti-CTLA4 and TUNEL (terminal deoxynucleotidyl transferase nick-end-labeling) analysis revealed that apoptosis was a characteristic of B7.1+B7.2+CTLA4+ T cells. These data support the hypothesis that lymph node apoptosis and immune deterioration in FIV-infected cats results from chronic B7.1- and/or B7.2-CTLA4-mediated T-T interactions.</description><subject>Abatacept</subject><subject>Animals</subject><subject>Antigens, CD - analysis</subject><subject>Antigens, Differentiation - analysis</subject><subject>Apoptosis</subject><subject>B7-1 Antigen - analysis</subject><subject>B7-2 Antigen</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>CTLA-4 Antigen</subject><subject>Experimental viral diseases and models</subject><subject>Feline Acquired Immunodeficiency Syndrome - immunology</subject><subject>Immunoconjugates</subject><subject>In Situ Nick-End Labeling</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - analysis</subject><subject>T-Lymphocytes - physiology</subject><subject>Viral diseases</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10FGL1DAUBeAgijuu-hMkLujLUk1y26R9nC3u7uiA4o6L-BIyNylmbZuatOD46-0ygwOCT_fl45zLIeQ5Z284K-VbgKrM1QOy4AWoTEoOD8mCMSEyXlbVCXmS0h1jLAepHpMTzitgwMsFub10re8dXXXd1AfrGo_e9bijtz5Oia76xuHoQ09XidbfTTQ4uuh_O0u3O3qhzuvNepmf0w2tXdvS5RCGMSSfnpJHjWmTe3a4p-TL5btNfZ2tP16t6uU6QxDlmBVKGMsQKtE0uYXGlAql5axAMHMxsyIXYFVhuEGL1vLtFo3DvABjJVoGp-T1PneI4efk0qg7n3B-xfQuTEkrXkhZKpjh2T_wLkyxn3_TQkDFcgnqmIYxpBRdo4foOxN3mjN9P7PezzzDF4e0ads5e2SHXWfw6gBMQtM20fTo09GBFDmU9-7l3oVp-H9Ztjc-je7XX2XiDy0VqEJff_2m2cWHq5v3nz7rG_gDYzOcVg</recordid><startdate>20020415</startdate><enddate>20020415</enddate><creator>Tompkins, Mary B.</creator><creator>Bull, Marta E.</creator><creator>Dow, Janet L.</creator><creator>Ball, Judith M.</creator><creator>Collisson, Ellen W.</creator><creator>Winslow, Barbara J.</creator><creator>Phadke, Anagha P.</creator><creator>Vahlenkamp, Thomas W.</creator><creator>Tompkins, Wayne A.</creator><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20020415</creationdate><title>Feline Immunodeficiency Virus Infection Is Characterized by B7+CTLA4+ T Cell Apoptosis</title><author>Tompkins, Mary B. ; Bull, Marta E. ; Dow, Janet L. ; Ball, Judith M. ; Collisson, Ellen W. ; Winslow, Barbara J. ; Phadke, Anagha P. ; Vahlenkamp, Thomas W. ; Tompkins, Wayne A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-572ad0c392ff4d3fa87c6d105c3afec0d2423d75a1acdcdd1bbcaec453ad6cd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Abatacept</topic><topic>Animals</topic><topic>Antigens, CD - analysis</topic><topic>Antigens, Differentiation - analysis</topic><topic>Apoptosis</topic><topic>B7-1 Antigen - analysis</topic><topic>B7-2 Antigen</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>CTLA-4 Antigen</topic><topic>Experimental viral diseases and models</topic><topic>Feline Acquired Immunodeficiency Syndrome - immunology</topic><topic>Immunoconjugates</topic><topic>In Situ Nick-End Labeling</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - analysis</topic><topic>T-Lymphocytes - physiology</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tompkins, Mary B.</creatorcontrib><creatorcontrib>Bull, Marta E.</creatorcontrib><creatorcontrib>Dow, Janet L.</creatorcontrib><creatorcontrib>Ball, Judith M.</creatorcontrib><creatorcontrib>Collisson, Ellen W.</creatorcontrib><creatorcontrib>Winslow, Barbara J.</creatorcontrib><creatorcontrib>Phadke, Anagha P.</creatorcontrib><creatorcontrib>Vahlenkamp, Thomas W.</creatorcontrib><creatorcontrib>Tompkins, Wayne A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tompkins, Mary B.</au><au>Bull, Marta E.</au><au>Dow, Janet L.</au><au>Ball, Judith M.</au><au>Collisson, Ellen W.</au><au>Winslow, Barbara J.</au><au>Phadke, Anagha P.</au><au>Vahlenkamp, Thomas W.</au><au>Tompkins, Wayne A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feline Immunodeficiency Virus Infection Is Characterized by B7+CTLA4+ T Cell Apoptosis</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2002-04-15</date><risdate>2002</risdate><volume>185</volume><issue>8</issue><spage>1077</spage><epage>1093</epage><pages>1077-1093</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The B7.1 and B7.2 costimulatory molecules on antigen-presenting cells provide second signals for regulating T cell immune responses via CD28 and cytotoxic T lymphocyte antigen 4 (CTLA4) on T cells. CD28 signals cell proliferation, whereas CTLA4 signals for anergy or apoptosis, terminating the immune response. Because T cell apoptosis and immunodeficiency is a characteristic of feline immunodeficiency virus (FIV)-infected cats, it is possible that negative T cell signaling via B7 and CTLA4 may be favored in these cats. Flow cytometry revealed high percentages of CD8+ and CD4+ cells expressing B7.1, B7.2, and CTLA4 in lymph nodes of FIV-positive cats and a large fraction of CTLA4+ T cells coexpressing B7.1 and B7.2. Three-color analysis with anti-B7.1, antiB7.2, or anti-CTLA4 and TUNEL (terminal deoxynucleotidyl transferase nick-end-labeling) analysis revealed that apoptosis was a characteristic of B7.1+B7.2+CTLA4+ T cells. These data support the hypothesis that lymph node apoptosis and immune deterioration in FIV-infected cats results from chronic B7.1- and/or B7.2-CTLA4-mediated T-T interactions.</abstract><cop>Chicago, IL</cop><pub>University of Chicago Press</pub><pmid>11930318</pmid><doi>10.1086/339847</doi><tpages>17</tpages></addata></record> |
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| subjects | Abatacept Animals Antigens, CD - analysis Antigens, Differentiation - analysis Apoptosis B7-1 Antigen - analysis B7-2 Antigen Biological and medical sciences Cats CTLA-4 Antigen Experimental viral diseases and models Feline Acquired Immunodeficiency Syndrome - immunology Immunoconjugates In Situ Nick-End Labeling Infectious diseases Medical sciences Membrane Glycoproteins - analysis T-Lymphocytes - physiology Viral diseases |
| title | Feline Immunodeficiency Virus Infection Is Characterized by B7+CTLA4+ T Cell Apoptosis |
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