Disposition of radiolabeled BMS-204352 in rats and dogs

BMS‐204352, a maxi‐K channel opener, is currently under development for the treatment of stroke. The objective of this study was to determine the pharmacokinetics, mass balance and absolute oral bioavailability of [14C]‐BMS‐204352 in rats and dogs. [14C]‐BMS‐204352 was administered, to rats (n=10/gr...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2002-01, Vol.23 (1), p.41-46
Hauptverfasser:	Krishna, Rajesh, Yao, Ming, Srinivas, Nuggehally R., Shah, Vinod, Pursley, Janice M., Arnold, Mark, Vachharajani, Nimish N.
Format:	Artikel
Sprache:	eng
Schlagworte:	absolute bioavailability Administration, Oral Animals Biological and medical sciences Biological Availability BMS-204352 Carbon Radioisotopes Dogs Indoles - pharmacokinetics Male mass balance Medical sciences Neuropharmacology Neuroprotective agent Neuroprotective Agents - pharmacokinetics Pharmacology. Drug treatments Potassium Channels - drug effects Rats Rats, Sprague-Dawley Stroke - drug therapy
Online-Zugang:	Volltext
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