Mechanisms of Caspase Activation and Inhibition during Apoptosis
Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. This article reviews these latest advances and presents ou...
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| Veröffentlicht in: | Molecular cell 2002-03, Vol.9 (3), p.459-470 |
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| container_title | Molecular cell |
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| creator | Shi, Yigong |
| description | Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. This article reviews these latest advances and presents our current understanding of caspase regulation during apoptosis. |
| doi_str_mv | 10.1016/S1097-2765(02)00482-3 |
| format | Article |
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Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. 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| ispartof | Molecular cell, 2002-03, Vol.9 (3), p.459-470 |
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| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Apoptosis - physiology Binding Sites Caspase Inhibitors Caspases - chemistry Caspases - classification Caspases - metabolism Enzyme Activation Inhibitor of Apoptosis Proteins Insect Proteins - metabolism Models, Biological Models, Molecular Protein Conformation Protein Precursors - metabolism Protein Structure, Tertiary Proteins |
| title | Mechanisms of Caspase Activation and Inhibition during Apoptosis |
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