Mechanisms of Caspase Activation and Inhibition during Apoptosis

Mechanisms of Caspase Activation and Inhibition during Apoptosis

Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. This article reviews these latest advances and presents ou...

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Veröffentlicht in:Molecular cell 2002-03, Vol.9 (3), p.459-470
1. Verfasser: Shi, Yigong
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Apoptosis - physiology
Binding Sites
Caspase Inhibitors
Caspases - chemistry
Caspases - classification
Caspases - metabolism
Enzyme Activation
Inhibitor of Apoptosis Proteins
Insect Proteins - metabolism
Models, Biological
Models, Molecular
Protein Conformation
Protein Precursors - metabolism
Protein Structure, Tertiary
Proteins
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Beschreibung
Zusammenfassung:Caspases are central components of the machinery responsible for apoptosis. Recent structural and biochemical studies on procaspases, IAPs, Smac/DIABLO, and apoptosome have revealed a conserved mechanism of caspase activation and inhibition. This article reviews these latest advances and presents our current understanding of caspase regulation during apoptosis.
ISSN:1097-2765
1097-4164
DOI:10.1016/S1097-2765(02)00482-3