Re-Screening serotonin receptors for genetic variants identifies population and molecular genetic complexity
We have re‐screened the genes for the 5‐HT1A, 5‐HT2A, 5‐HT2C, and 5‐HT7 serotonin receptors for genetic variants in a large African‐American and Caucasian‐American population sample. We have identified eight novel variants in these genes including four that are predicted to cause amino acid substitu...
Gespeichert in:
| Veröffentlicht in: | American journal of medical genetics 2004-01, Vol.124B (1), p.92-100 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 100 |
|---|---|
| container_issue | 1 |
| container_start_page | 92 |
| container_title | American journal of medical genetics |
| container_volume | 124B |
| creator | Glatt, Charles E. Tampilic, Maricel Christie, Carroll DeYoung, Joe Freimer, Nelson B. |
| description | We have re‐screened the genes for the 5‐HT1A, 5‐HT2A, 5‐HT2C, and 5‐HT7 serotonin receptors for genetic variants in a large African‐American and Caucasian‐American population sample. We have identified eight novel variants in these genes including four that are predicted to cause amino acid substitutions. These variants are additional candidates for association studies of behavioral disorders such as depression and schizophrenia as well as quantitative personality traits. We have also detected some, but not all, previously identified variants in these genes suggesting that many previously identified variants are unique to specific populations. The results of this study, and previous screens of serotonin receptors, demonstrate that the genes for serotonin receptors display marked population and molecular genetic complexity. These levels of complexity may have a substantial effect on genetic association studies of human behavioral variability related to these genes. We discuss the implications of these findings and propose methods to address complexity in genetic association studies. © 2003 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajmg.b.20056 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71566436</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71566436</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3996-e3c0814fbadf7b91af71e5a9a62bc6c66b91b50f10bade92559e06554cc9d5ca3</originalsourceid><addsrcrecordid>eNp90MtvEzEQB2ALgegDbpyRL3Big71-ZY8lglBaQOIhcrO83nHksmsvtlOa_55tkzY3TjMafTMj_RB6QcmMElK_NVfDetbOakKEfISOqRB1xedi9fih5_QIneR8RQgjQqmn6IhyOadNzY5R_w2q7zYBBB_WOEOKJU4tTmBhLDFl7GLCawhQvMXXJnkTSsa-g1C885DxGMdNb4qPAZvQ4SH2YKfBYcnGYezhxpftM_TEmT7D8309RT8_vP-x-Fhdfl2eL84uK8uaRlbALJlT7lrTOdU21DhFQZjGyLq10ko5zVpBHCWTgKYWogEiheDWNp2whp2i17u7Y4p_NpCLHny20PcmQNxkraiQkjM5wTc7aFPMOYHTY_KDSVtNib5NV9-mq1t9l-7EX-7vbtoBugPexzmBV3tgsjW9SyZYnw9OcM7IXE2O7dxf38P2v0_12afPy_v31W7L5wI3D1sm_dZSMSX0ry9L_U5dqBVfLfWC_QN_76WT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71566436</pqid></control><display><type>article</type><title>Re-Screening serotonin receptors for genetic variants identifies population and molecular genetic complexity</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Glatt, Charles E. ; Tampilic, Maricel ; Christie, Carroll ; DeYoung, Joe ; Freimer, Nelson B.</creator><creatorcontrib>Glatt, Charles E. ; Tampilic, Maricel ; Christie, Carroll ; DeYoung, Joe ; Freimer, Nelson B.</creatorcontrib><description>We have re‐screened the genes for the 5‐HT1A, 5‐HT2A, 5‐HT2C, and 5‐HT7 serotonin receptors for genetic variants in a large African‐American and Caucasian‐American population sample. We have identified eight novel variants in these genes including four that are predicted to cause amino acid substitutions. These variants are additional candidates for association studies of behavioral disorders such as depression and schizophrenia as well as quantitative personality traits. We have also detected some, but not all, previously identified variants in these genes suggesting that many previously identified variants are unique to specific populations. The results of this study, and previous screens of serotonin receptors, demonstrate that the genes for serotonin receptors display marked population and molecular genetic complexity. These levels of complexity may have a substantial effect on genetic association studies of human behavioral variability related to these genes. We discuss the implications of these findings and propose methods to address complexity in genetic association studies. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 1552-4841</identifier><identifier>ISSN: 0148-7299</identifier><identifier>EISSN: 1552-485X</identifier><identifier>EISSN: 1096-8628</identifier><identifier>DOI: 10.1002/ajmg.b.20056</identifier><identifier>PMID: 14681923</identifier><identifier>CODEN: AJMGDA</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>African Americans - genetics ; Alleles ; Amino Acid Sequence ; behavioral genetics ; Biological and medical sciences ; DNA - chemistry ; DNA - genetics ; DNA Mutational Analysis ; European Continental Ancestry Group - genetics ; Gene Frequency ; General aspects. Genetic counseling ; genetic heterogeneity ; Genetic Testing ; Genetic Variation ; Haplotypes - genetics ; Humans ; Medical genetics ; Medical sciences ; Mental Disorders - diagnosis ; Mental Disorders - genetics ; Molecular Sequence Data ; Polymorphism, Single Nucleotide ; Receptor, Serotonin, 5-HT1A - genetics ; Receptor, Serotonin, 5-HT2A - genetics ; Receptor, Serotonin, 5-HT2C - genetics ; Receptors, Serotonin - genetics ; Sequence Homology ; single nucleotide polymorphism denaturing high-performance liquid chromatography</subject><ispartof>American journal of medical genetics, 2004-01, Vol.124B (1), p.92-100</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3996-e3c0814fbadf7b91af71e5a9a62bc6c66b91b50f10bade92559e06554cc9d5ca3</citedby><cites>FETCH-LOGICAL-c3996-e3c0814fbadf7b91af71e5a9a62bc6c66b91b50f10bade92559e06554cc9d5ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajmg.b.20056$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajmg.b.20056$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15443087$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14681923$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Glatt, Charles E.</creatorcontrib><creatorcontrib>Tampilic, Maricel</creatorcontrib><creatorcontrib>Christie, Carroll</creatorcontrib><creatorcontrib>DeYoung, Joe</creatorcontrib><creatorcontrib>Freimer, Nelson B.</creatorcontrib><title>Re-Screening serotonin receptors for genetic variants identifies population and molecular genetic complexity</title><title>American journal of medical genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>We have re‐screened the genes for the 5‐HT1A, 5‐HT2A, 5‐HT2C, and 5‐HT7 serotonin receptors for genetic variants in a large African‐American and Caucasian‐American population sample. We have identified eight novel variants in these genes including four that are predicted to cause amino acid substitutions. These variants are additional candidates for association studies of behavioral disorders such as depression and schizophrenia as well as quantitative personality traits. We have also detected some, but not all, previously identified variants in these genes suggesting that many previously identified variants are unique to specific populations. The results of this study, and previous screens of serotonin receptors, demonstrate that the genes for serotonin receptors display marked population and molecular genetic complexity. These levels of complexity may have a substantial effect on genetic association studies of human behavioral variability related to these genes. We discuss the implications of these findings and propose methods to address complexity in genetic association studies. © 2003 Wiley‐Liss, Inc.</description><subject>African Americans - genetics</subject><subject>Alleles</subject><subject>Amino Acid Sequence</subject><subject>behavioral genetics</subject><subject>Biological and medical sciences</subject><subject>DNA - chemistry</subject><subject>DNA - genetics</subject><subject>DNA Mutational Analysis</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Gene Frequency</subject><subject>General aspects. Genetic counseling</subject><subject>genetic heterogeneity</subject><subject>Genetic Testing</subject><subject>Genetic Variation</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Mental Disorders - diagnosis</subject><subject>Mental Disorders - genetics</subject><subject>Molecular Sequence Data</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptor, Serotonin, 5-HT1A - genetics</subject><subject>Receptor, Serotonin, 5-HT2A - genetics</subject><subject>Receptor, Serotonin, 5-HT2C - genetics</subject><subject>Receptors, Serotonin - genetics</subject><subject>Sequence Homology</subject><subject>single nucleotide polymorphism denaturing high-performance liquid chromatography</subject><issn>1552-4841</issn><issn>0148-7299</issn><issn>1552-485X</issn><issn>1096-8628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MtvEzEQB2ALgegDbpyRL3Big71-ZY8lglBaQOIhcrO83nHksmsvtlOa_55tkzY3TjMafTMj_RB6QcmMElK_NVfDetbOakKEfISOqRB1xedi9fih5_QIneR8RQgjQqmn6IhyOadNzY5R_w2q7zYBBB_WOEOKJU4tTmBhLDFl7GLCawhQvMXXJnkTSsa-g1C885DxGMdNb4qPAZvQ4SH2YKfBYcnGYezhxpftM_TEmT7D8309RT8_vP-x-Fhdfl2eL84uK8uaRlbALJlT7lrTOdU21DhFQZjGyLq10ko5zVpBHCWTgKYWogEiheDWNp2whp2i17u7Y4p_NpCLHny20PcmQNxkraiQkjM5wTc7aFPMOYHTY_KDSVtNib5NV9-mq1t9l-7EX-7vbtoBugPexzmBV3tgsjW9SyZYnw9OcM7IXE2O7dxf38P2v0_12afPy_v31W7L5wI3D1sm_dZSMSX0ry9L_U5dqBVfLfWC_QN_76WT</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Glatt, Charles E.</creator><creator>Tampilic, Maricel</creator><creator>Christie, Carroll</creator><creator>DeYoung, Joe</creator><creator>Freimer, Nelson B.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040101</creationdate><title>Re-Screening serotonin receptors for genetic variants identifies population and molecular genetic complexity</title><author>Glatt, Charles E. ; Tampilic, Maricel ; Christie, Carroll ; DeYoung, Joe ; Freimer, Nelson B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3996-e3c0814fbadf7b91af71e5a9a62bc6c66b91b50f10bade92559e06554cc9d5ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>African Americans - genetics</topic><topic>Alleles</topic><topic>Amino Acid Sequence</topic><topic>behavioral genetics</topic><topic>Biological and medical sciences</topic><topic>DNA - chemistry</topic><topic>DNA - genetics</topic><topic>DNA Mutational Analysis</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Gene Frequency</topic><topic>General aspects. Genetic counseling</topic><topic>genetic heterogeneity</topic><topic>Genetic Testing</topic><topic>Genetic Variation</topic><topic>Haplotypes - genetics</topic><topic>Humans</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Mental Disorders - diagnosis</topic><topic>Mental Disorders - genetics</topic><topic>Molecular Sequence Data</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptor, Serotonin, 5-HT1A - genetics</topic><topic>Receptor, Serotonin, 5-HT2A - genetics</topic><topic>Receptor, Serotonin, 5-HT2C - genetics</topic><topic>Receptors, Serotonin - genetics</topic><topic>Sequence Homology</topic><topic>single nucleotide polymorphism denaturing high-performance liquid chromatography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Glatt, Charles E.</creatorcontrib><creatorcontrib>Tampilic, Maricel</creatorcontrib><creatorcontrib>Christie, Carroll</creatorcontrib><creatorcontrib>DeYoung, Joe</creatorcontrib><creatorcontrib>Freimer, Nelson B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of medical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Glatt, Charles E.</au><au>Tampilic, Maricel</au><au>Christie, Carroll</au><au>DeYoung, Joe</au><au>Freimer, Nelson B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Re-Screening serotonin receptors for genetic variants identifies population and molecular genetic complexity</atitle><jtitle>American journal of medical genetics</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>124B</volume><issue>1</issue><spage>92</spage><epage>100</epage><pages>92-100</pages><issn>1552-4841</issn><issn>0148-7299</issn><eissn>1552-485X</eissn><eissn>1096-8628</eissn><coden>AJMGDA</coden><abstract>We have re‐screened the genes for the 5‐HT1A, 5‐HT2A, 5‐HT2C, and 5‐HT7 serotonin receptors for genetic variants in a large African‐American and Caucasian‐American population sample. We have identified eight novel variants in these genes including four that are predicted to cause amino acid substitutions. These variants are additional candidates for association studies of behavioral disorders such as depression and schizophrenia as well as quantitative personality traits. We have also detected some, but not all, previously identified variants in these genes suggesting that many previously identified variants are unique to specific populations. The results of this study, and previous screens of serotonin receptors, demonstrate that the genes for serotonin receptors display marked population and molecular genetic complexity. These levels of complexity may have a substantial effect on genetic association studies of human behavioral variability related to these genes. We discuss the implications of these findings and propose methods to address complexity in genetic association studies. © 2003 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>14681923</pmid><doi>10.1002/ajmg.b.20056</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-4841 |
| ispartof | American journal of medical genetics, 2004-01, Vol.124B (1), p.92-100 |
| issn | 1552-4841 0148-7299 1552-485X 1096-8628 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71566436 |
| source | MEDLINE; Wiley Journals |
| subjects | African Americans - genetics Alleles Amino Acid Sequence behavioral genetics Biological and medical sciences DNA - chemistry DNA - genetics DNA Mutational Analysis European Continental Ancestry Group - genetics Gene Frequency General aspects. Genetic counseling genetic heterogeneity Genetic Testing Genetic Variation Haplotypes - genetics Humans Medical genetics Medical sciences Mental Disorders - diagnosis Mental Disorders - genetics Molecular Sequence Data Polymorphism, Single Nucleotide Receptor, Serotonin, 5-HT1A - genetics Receptor, Serotonin, 5-HT2A - genetics Receptor, Serotonin, 5-HT2C - genetics Receptors, Serotonin - genetics Sequence Homology single nucleotide polymorphism denaturing high-performance liquid chromatography |
| title | Re-Screening serotonin receptors for genetic variants identifies population and molecular genetic complexity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T07%3A23%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Re-Screening%20serotonin%20receptors%20for%20genetic%20variants%20identifies%20population%20and%20molecular%20genetic%20complexity&rft.jtitle=American%20journal%20of%20medical%20genetics&rft.au=Glatt,%20Charles%20E.&rft.date=2004-01-01&rft.volume=124B&rft.issue=1&rft.spage=92&rft.epage=100&rft.pages=92-100&rft.issn=1552-4841&rft.eissn=1552-485X&rft.coden=AJMGDA&rft_id=info:doi/10.1002/ajmg.b.20056&rft_dat=%3Cproquest_cross%3E71566436%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71566436&rft_id=info:pmid/14681923&rfr_iscdi=true |