Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes

WB4101 (1)-related compounds 5-10 were synthesized, and their biological profile at alpha(1)-adrenoreceptor (AR) subtypes and 5-HT(1A) serotoninergic receptors was assessed by binding assays in Chinese hamster ovary and HeLa cell membranes expressing the human cloned receptors. Moreover, their recep...

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Veröffentlicht in:	Journal of medicinal chemistry 2002-04, Vol.45 (8), p.1633-1643
Hauptverfasser:	Quaglia, Wilma, Pigini, Maria, Piergentili, Alessandro, Giannella, Mario, Gentili, Francesco, Marucci, Gabriella, Carrieri, Antonio, Carotti, Angelo, Poggesi, Elena, Leonardi, Amedeo, Melchiorre, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Antagonists - chemical synthesis Adrenergic alpha-Antagonists - chemistry Adrenergic alpha-Antagonists - pharmacology Animals Aorta, Thoracic - drug effects Aorta, Thoracic - physiology CHO Cells Chromans - chemical synthesis Chromans - chemistry Chromans - pharmacology Cricetinae Dioxanes - chemical synthesis Dioxanes - chemistry Dioxanes - pharmacology HeLa Cells Humans In Vitro Techniques Male Models, Molecular Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Prostate - drug effects Prostate - physiology Radioligand Assay Rats Rats, Wistar Receptors, Adrenergic, alpha-1 - drug effects Receptors, Adrenergic, alpha-1 - metabolism Receptors, Serotonin - metabolism Receptors, Serotonin, 5-HT1 Spleen - drug effects Spleen - physiology Structure-Activity Relationship Vas Deferens - drug effects Vas Deferens - physiology
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