Regulation of global and specific mRNA translation by oral administration of branched-chain amino acids

The importance of branched-chain amino acids as nutrient regulators of protein synthesis in skeletal muscle was recognized more than 20 years ago. Of the branched-chain amino acids, leucine in particular was shown to play a central role in promoting muscle protein synthesis. However, it was only rec...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-01, Vol.313 (2), p.423-427
Hauptverfasser:	Kimball, Scot R., Jefferson, Leonard S.
Format:	Artikel
Sprache:	eng
Schlagworte:	4E-BP1 protein Administration, Oral Amino Acids, Branched-Chain - pharmacology Amino Acids, Branched-Chain - physiology Animals Eukaryotic initiation factor Gene Expression Regulation - drug effects Glucocorticoids - antagonists & inhibitors Insulin - metabolism Leucine - pharmacology Leucine - physiology Mammalian target of rapamycin mTOR protein Muscle, Skeletal - metabolism Protein Biosynthesis - drug effects Proteins - genetics Ribosomal protein S6 S6K protein S6K1 Signal Transduction Tissue Distribution TOP mRNA Translation initiation
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