Anaplastic large cell lymphoma of the mediastinum diagnosed by transbronchial scratch cytology: A case report
Anaplastic large cell lymphoma (ALCL) is a subtype of non-Hodgkin's lymphoma characterized by CD30 antigen-positive, large neoplastic cells. We describe a case of ALCL suggested by cytologic examination of the tumor cells obtained from bronchial scratch preparations. A 26-year-old woman had had...
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| Veröffentlicht in: | Acta cytologica 2002-03, Vol.46 (2), p.405-411 |
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| container_title | Acta cytologica |
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| creator | KAYAO, Junko TAMARU, Jun-Ichi WAKITA, Hisasi SAITOU, Tadasi KUZUU, Yoshihiko MIKATA, Atsuo TANAKA, Noboru |
| description | Anaplastic large cell lymphoma (ALCL) is a subtype of non-Hodgkin's lymphoma characterized by CD30 antigen-positive, large neoplastic cells. We describe a case of ALCL suggested by cytologic examination of the tumor cells obtained from bronchial scratch preparations.
A 26-year-old woman had had a dry cough since November 1996. Chest radiography in May 1997 revealed an abnormal shadow in the mediastinum extending to the pulmonary hilar region. The patient was hospitalized in June 1997. Computed tomography revealed a neoplastic lesion in the anterior mediastinum invading the right lung. Transbronchial scratch cytology revealed large, atypical lymphoid cells expressing CD30 and CD3 on immunocytochemical examination. A transcutaneous mediastinal biopsy was performed and a diagnosis of ALCL made.
Differentiation from Hodgkin's disease was the most difficult point in this case. Detailed cytologic observation and CD3-positive immunocytology led to the correct diagnosis. The cell transfer technique of Sherman et al was very useful for immunocytologic staining. Thus, transbronchial scratch cytology was an especially valuable and effective procedure in this case. |
| doi_str_mv | 10.1159/000326741 |
| format | Article |
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A 26-year-old woman had had a dry cough since November 1996. Chest radiography in May 1997 revealed an abnormal shadow in the mediastinum extending to the pulmonary hilar region. The patient was hospitalized in June 1997. Computed tomography revealed a neoplastic lesion in the anterior mediastinum invading the right lung. Transbronchial scratch cytology revealed large, atypical lymphoid cells expressing CD30 and CD3 on immunocytochemical examination. A transcutaneous mediastinal biopsy was performed and a diagnosis of ALCL made.
Differentiation from Hodgkin's disease was the most difficult point in this case. Detailed cytologic observation and CD3-positive immunocytology led to the correct diagnosis. The cell transfer technique of Sherman et al was very useful for immunocytologic staining. Thus, transbronchial scratch cytology was an especially valuable and effective procedure in this case.</description><identifier>ISSN: 0001-5547</identifier><identifier>EISSN: 1938-2650</identifier><identifier>DOI: 10.1159/000326741</identifier><identifier>PMID: 11917593</identifier><identifier>CODEN: ACYTAN</identifier><language>eng</language><publisher>St. Louis, MO: Science Printers and Publishers</publisher><subject>Adult ; Biological and medical sciences ; Biopsy ; Bronchi - pathology ; Diagnosis, Differential ; Female ; Hematologic and hematopoietic diseases ; Hodgkin Disease - diagnosis ; Hodgkin Disease - pathology ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Large-Cell, Anaplastic - diagnosis ; Lymphoma, Large-Cell, Anaplastic - pathology ; Mediastinal Neoplasms - diagnosis ; Mediastinal Neoplasms - pathology ; Medical sciences</subject><ispartof>Acta cytologica, 2002-03, Vol.46 (2), p.405-411</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13569315$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11917593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAYAO, Junko</creatorcontrib><creatorcontrib>TAMARU, Jun-Ichi</creatorcontrib><creatorcontrib>WAKITA, Hisasi</creatorcontrib><creatorcontrib>SAITOU, Tadasi</creatorcontrib><creatorcontrib>KUZUU, Yoshihiko</creatorcontrib><creatorcontrib>MIKATA, Atsuo</creatorcontrib><creatorcontrib>TANAKA, Noboru</creatorcontrib><title>Anaplastic large cell lymphoma of the mediastinum diagnosed by transbronchial scratch cytology: A case report</title><title>Acta cytologica</title><addtitle>Acta Cytol</addtitle><description>Anaplastic large cell lymphoma (ALCL) is a subtype of non-Hodgkin's lymphoma characterized by CD30 antigen-positive, large neoplastic cells. We describe a case of ALCL suggested by cytologic examination of the tumor cells obtained from bronchial scratch preparations.
A 26-year-old woman had had a dry cough since November 1996. Chest radiography in May 1997 revealed an abnormal shadow in the mediastinum extending to the pulmonary hilar region. The patient was hospitalized in June 1997. Computed tomography revealed a neoplastic lesion in the anterior mediastinum invading the right lung. Transbronchial scratch cytology revealed large, atypical lymphoid cells expressing CD30 and CD3 on immunocytochemical examination. A transcutaneous mediastinal biopsy was performed and a diagnosis of ALCL made.
Differentiation from Hodgkin's disease was the most difficult point in this case. Detailed cytologic observation and CD3-positive immunocytology led to the correct diagnosis. The cell transfer technique of Sherman et al was very useful for immunocytologic staining. Thus, transbronchial scratch cytology was an especially valuable and effective procedure in this case.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Bronchi - pathology</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hodgkin Disease - diagnosis</subject><subject>Hodgkin Disease - pathology</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Large-Cell, Anaplastic - diagnosis</subject><subject>Lymphoma, Large-Cell, Anaplastic - pathology</subject><subject>Mediastinal Neoplasms - diagnosis</subject><subject>Mediastinal Neoplasms - pathology</subject><subject>Medical sciences</subject><issn>0001-5547</issn><issn>1938-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LxDAQBuAgiruuHvwDkoveqvlo0o23ZfELFrzouUzT6baSNjVpD_33dnHF0wzDwwvvEHLN2T3nyjwwxqTQWcpPyJIbuU6EVuyULOc7T5RKswW5iPFrVlJreU4WnBueKSOXpN100DuIQ2Opg7BHatE56qa2r30L1Fd0qJG2WDYH1I0tnbd95yOWtJjoEKCLRfCdrRtwNNoAg62pnQbv_H56pBtqISIN2PswXJKzClzEq-Nckc_np4_ta7J7f3nbbnZJL2Q2JJkETAVqkQllRFUhswaxkhUzRQlM4Bp4ClgWVlvgZcEzkxYsRSxtuZZpIVfk7je3D_57xDjkbRMPxaBDP8Y840oLxvQMb45wLOaOeR-aFsKU_z1oBrdHANGCq-a6ton_TiptJFfyB32Bdgk</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>KAYAO, Junko</creator><creator>TAMARU, Jun-Ichi</creator><creator>WAKITA, Hisasi</creator><creator>SAITOU, Tadasi</creator><creator>KUZUU, Yoshihiko</creator><creator>MIKATA, Atsuo</creator><creator>TANAKA, Noboru</creator><general>Science Printers and Publishers</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Anaplastic large cell lymphoma of the mediastinum diagnosed by transbronchial scratch cytology: A case report</title><author>KAYAO, Junko ; TAMARU, Jun-Ichi ; WAKITA, Hisasi ; SAITOU, Tadasi ; KUZUU, Yoshihiko ; MIKATA, Atsuo ; TANAKA, Noboru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-73ae42e6272592ffe0c9eef3f09bda02e8a14aedbc6ca1db1794b04eedcd834b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Bronchi - pathology</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hodgkin Disease - diagnosis</topic><topic>Hodgkin Disease - pathology</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Large-Cell, Anaplastic - diagnosis</topic><topic>Lymphoma, Large-Cell, Anaplastic - pathology</topic><topic>Mediastinal Neoplasms - diagnosis</topic><topic>Mediastinal Neoplasms - pathology</topic><topic>Medical sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAYAO, Junko</creatorcontrib><creatorcontrib>TAMARU, Jun-Ichi</creatorcontrib><creatorcontrib>WAKITA, Hisasi</creatorcontrib><creatorcontrib>SAITOU, Tadasi</creatorcontrib><creatorcontrib>KUZUU, Yoshihiko</creatorcontrib><creatorcontrib>MIKATA, Atsuo</creatorcontrib><creatorcontrib>TANAKA, Noboru</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta cytologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAYAO, Junko</au><au>TAMARU, Jun-Ichi</au><au>WAKITA, Hisasi</au><au>SAITOU, Tadasi</au><au>KUZUU, Yoshihiko</au><au>MIKATA, Atsuo</au><au>TANAKA, Noboru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anaplastic large cell lymphoma of the mediastinum diagnosed by transbronchial scratch cytology: A case report</atitle><jtitle>Acta cytologica</jtitle><addtitle>Acta Cytol</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>46</volume><issue>2</issue><spage>405</spage><epage>411</epage><pages>405-411</pages><issn>0001-5547</issn><eissn>1938-2650</eissn><coden>ACYTAN</coden><abstract>Anaplastic large cell lymphoma (ALCL) is a subtype of non-Hodgkin's lymphoma characterized by CD30 antigen-positive, large neoplastic cells. We describe a case of ALCL suggested by cytologic examination of the tumor cells obtained from bronchial scratch preparations.
A 26-year-old woman had had a dry cough since November 1996. Chest radiography in May 1997 revealed an abnormal shadow in the mediastinum extending to the pulmonary hilar region. The patient was hospitalized in June 1997. Computed tomography revealed a neoplastic lesion in the anterior mediastinum invading the right lung. Transbronchial scratch cytology revealed large, atypical lymphoid cells expressing CD30 and CD3 on immunocytochemical examination. A transcutaneous mediastinal biopsy was performed and a diagnosis of ALCL made.
Differentiation from Hodgkin's disease was the most difficult point in this case. Detailed cytologic observation and CD3-positive immunocytology led to the correct diagnosis. The cell transfer technique of Sherman et al was very useful for immunocytologic staining. Thus, transbronchial scratch cytology was an especially valuable and effective procedure in this case.</abstract><cop>St. Louis, MO</cop><pub>Science Printers and Publishers</pub><pmid>11917593</pmid><doi>10.1159/000326741</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Biopsy Bronchi - pathology Diagnosis, Differential Female Hematologic and hematopoietic diseases Hodgkin Disease - diagnosis Hodgkin Disease - pathology Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Large-Cell, Anaplastic - diagnosis Lymphoma, Large-Cell, Anaplastic - pathology Mediastinal Neoplasms - diagnosis Mediastinal Neoplasms - pathology Medical sciences |
| title | Anaplastic large cell lymphoma of the mediastinum diagnosed by transbronchial scratch cytology: A case report |
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