Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats

Extracts of leaves from the plant Stevia rebaudiana Bertoni have been used in the traditional treatment of diabetes in Paraguay and Brazil. Recently, we demonstrated a direct insulinotropic effect in isolated mouse islets and the clonal beta cell line INS-1 of the glycoside stevioside that is presen...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2002, Vol.9 (1), p.9-14
Hauptverfasser:	Jeppesen, P.B., Gregersen, S., Alstrup, K.K., Hermansen, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Area Under Curve Diabetes Mellitus, Type 2 - drug therapy Disease Models, Animal Diterpenes Diterpenes, Kaurane glucagon Glucagon - blood glucose Glucose - administration & dosage Glucose Tolerance Test Glucosides - administration & dosage Glucosides - therapeutic use Goto-Kakizaki rat Hyperglycemia - drug therapy Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - therapeutic use Injections, Intravenous insulin Insulin - blood Male Phytotherapy Plant Extracts - administration & dosage Plant Extracts - therapeutic use Rats Rats, Inbred Strains Rats, Wistar Stevioside Terpenes - administration & dosage Terpenes - therapeutic use type 2 diabetes Wistar rat
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