Ca2+ permeability of nicotinic acetylcholine receptors
Nicotinic acetylcholine receptors (nAChRs) are expressed in muscle cells and neurons, as well as in an increasing number of other cell types. The nAChR channels are permeable to cations, including Ca(2+). Ca(2+) entry through nAChR channels has been shown to modulate several Ca(2+)-dependent cellula...
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| Veröffentlicht in: | Cell calcium (Edinburgh) 2004-01, Vol.35 (1), p.1-8 |
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| creator | Fucile, Sergio |
| description | Nicotinic acetylcholine receptors (nAChRs) are expressed in muscle cells and neurons, as well as in an increasing number of other cell types. The nAChR channels are permeable to cations, including Ca(2+). Ca(2+) entry through nAChR channels has been shown to modulate several Ca(2+)-dependent cellular processes, such as neurotransmitter release, synaptic plasticity, and cell motility. The value of Ca(2+) permeability associated to a particular nAChR subtype thus represents an important indication for its physiological role. This review summarizes the quantitative data on Ca(2+) permeability obtained from several nAChR subtypes in native and heterologous systems. Different experimental approaches are compared, and the structural determinants of Ca(2+) permeability are discussed. |
| doi_str_mv | 10.1016/j.ceca.2003.08.006 |
| format | Article |
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Different experimental approaches are compared, and the structural determinants of Ca(2+) permeability are discussed.</description><identifier>ISSN: 0143-4160</identifier><identifier>DOI: 10.1016/j.ceca.2003.08.006</identifier><identifier>PMID: 14670366</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Amino Acid Sequence ; Animals ; Calcium - metabolism ; Cell Membrane Permeability ; Humans ; Molecular Sequence Data ; Muscles - metabolism ; Neurons - metabolism ; Receptors, Nicotinic - metabolism</subject><ispartof>Cell calcium (Edinburgh), 2004-01, Vol.35 (1), p.1-8</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c297t-7a772c1dea8be40f5ae249ded031c678d3a01483235fe82fabb765ca563b99c13</citedby><cites>FETCH-LOGICAL-c297t-7a772c1dea8be40f5ae249ded031c678d3a01483235fe82fabb765ca563b99c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14670366$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fucile, Sergio</creatorcontrib><title>Ca2+ permeability of nicotinic acetylcholine receptors</title><title>Cell calcium (Edinburgh)</title><addtitle>Cell Calcium</addtitle><description>Nicotinic acetylcholine receptors (nAChRs) are expressed in muscle cells and neurons, as well as in an increasing number of other cell types. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Amino Acid Sequence Animals Calcium - metabolism Cell Membrane Permeability Humans Molecular Sequence Data Muscles - metabolism Neurons - metabolism Receptors, Nicotinic - metabolism |
| title | Ca2+ permeability of nicotinic acetylcholine receptors |
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