Inhibition of tumor growth by systemic treatment with thrombospondin‐1 peptide mimetics

Many normal human cells produce thrombospondin‐1 (TSP‐1), a potent antiangiogenic protein that promotes vascular quiescence. In various organ systems, including the brain, breast and bladder and in fibroblasts, TSP‐1 secretion is reduced during tumorigenesis, thereby allowing induction of the vigoro...

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Veröffentlicht in:	International journal of cancer 2002-04, Vol.98 (5), p.682-689
Hauptverfasser:	Reiher, Frank K., Volpert, Olga V., Jimenez, Benilde, Crawford, Susan E., Dinney, Colin P., Henkin, Jack, Haviv, Fortuna, Bouck, Noel P., Campbell, Steven C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Apoptosis - drug effects Biological and medical sciences bladder cancer CD36 Antigens - metabolism Cell Division - drug effects Cell Division - physiology Chemotherapy Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Humans In Situ Nick-End Labeling Lung Neoplasms - blood supply Lung Neoplasms - metabolism Lung Neoplasms - prevention & control Male Medical sciences melanoma Melanoma, Experimental - drug therapy Melanoma, Experimental - pathology Mice Mice, Inbred C57BL Mice, Nude Molecular Mimicry Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Peptide Fragments - therapeutic use peptide mimetics Pharmacology. Drug treatments Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Proliferating Cell Nuclear Antigen - metabolism Thrombospondin 1 - therapeutic use thrombospondin‐1 tumor angiogenesis Urinary Bladder Neoplasms - blood supply Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - prevention & control
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