Topical Corticosteroids of Limited Potency Promote Adenovirus Replication in the Ad5/NZW Rabbit Ocular Model

PURPOSE.To determine the effect of topical therapy with several corticosteroids with limited potency on viral clearance in the adenovirus type 5 (Ad5) rabbit ocular model. METHODS.Sixty rabbits were inoculated in both eyes with Ad5. On the first day, the rabbits were equally divided into four topica...

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Veröffentlicht in:	Cornea 2002-04, Vol.21 (3), p.289-291
Hauptverfasser:	Romanowski, Eric G, Yates, Kathleen A, Gordon, Y Jerold
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Infections - drug therapy Adenoviridae Infections - virology Adenoviruses, Human - isolation & purification Adenoviruses, Human - physiology Administration, Topical Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - therapeutic use Cornea - virology Female Fluorometholone - administration & dosage Fluorometholone - therapeutic use Glucocorticoids Keratoconjunctivitis - drug therapy Keratoconjunctivitis - virology Models, Animal Prednisolone - administration & dosage Prednisolone - analogs & derivatives Prednisolone - therapeutic use Pregnadienes - administration & dosage Pregnadienes - therapeutic use Rabbits Virus Replication - drug effects
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