$Development and validation of a method to determine the unbound paclitaxel fraction in human plasma$

Development and validation of a method to determine the unbound paclitaxel fraction in human plasma

Paclitaxel is pharmaceutically formulated in a mixture of Cremophor EL and ethanol (1:1, v/v). The unbound fraction of the anticancer drug paclitaxel in plasma is dependent on both plasma protein binding and entrapment in Cremophor EL micelles. We have developed a simple and reproducible method for...

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Veröffentlicht in:	Analytical biochemistry 2004, Vol.324 (1), p.11-15
Hauptverfasser:	Desirée van den Bongard, H.J.G., Marleen Kemper, E., van Tellingen, Olaf, Rosing, Hilde, Mathôt, Ron A.A., Schellens, Jan H.M., Beijnen, Jos H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents, Phytogenic - blood Antineoplastic Agents, Phytogenic - therapeutic use Carbon Radioisotopes - analysis Countercurrent Distribution - methods Cremophor EL Glycerol - analogs & derivatives Glycerol - chemistry Hemofiltration Humans Male Micelles Paclitaxel Paclitaxel - blood Paclitaxel - chemistry Paclitaxel - therapeutic use Protein Binding Reproducibility of Results Scintillation Counting Serum Albumin - chemistry Solvents - chemistry Time Factors Tritium - analysis Unbound fraction in plasma
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