Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study
Herbal products are widely used by consumers as alternatives to prescription drugs in treating symptoms of allergic rhinitis. However, there have been few placebo-controlled clinical trials that have examined the efficacy or safety of these products. Although grapeseed extract (GSE) is an herbal tha...
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| Veröffentlicht in: | Annals of allergy, asthma, & immunology asthma, & immunology, 2002-03, Vol.88 (3), p.272-278 |
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| container_title | Annals of allergy, asthma, & immunology |
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| creator | Bernstein, David I. Bernstein, Cheryl K. Deng, Chunqin Murphy, Karen J. Bernstein, I.L. Bernstein, Jonathan A. Shukla, Rakesh |
| description | Herbal products are widely used by consumers as alternatives to prescription drugs in treating symptoms of allergic rhinitis. However, there have been few placebo-controlled clinical trials that have examined the efficacy or safety of these products. Although grapeseed extract (GSE) is an herbal that is marketed for treating allergic rhinitis, its efficacy is unproven.
The aim of this study was to compare the efficacy and safety of GSE with placebo in the treatment of seasonal allergic rhinitis (SAR).
This was a randomized, double-blind, placebo-controlled study of GSE 100 mg, twice daily, versus placebo. Patients with SAR and skin prick test sensitivity to ragweed were randomized to 8 weeks of active treatment or placebo which was begun before the ragweed pollen season. Outcomes included: daily symptom diary scores recorded by patients, rhinitis quality of life scores at baseline and after 4 and 8 weeks of treatment; and requirements for rescue chlorpheniramine. Safety was monitored with routine laboratory studies.
Over 8 weeks of treatment, no significant differences were observed between active and placebo groups in rhinitis quality of life assessments, symptom diary scores, or requirements for rescue antihistamine. No significant laboratory abnormalities were detected.
This study did not show trends supporting the efficacy of GSE in the treatment of SAR. |
| doi_str_mv | 10.1016/S1081-1206(10)62008-X |
| format | Article |
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The aim of this study was to compare the efficacy and safety of GSE with placebo in the treatment of seasonal allergic rhinitis (SAR).
This was a randomized, double-blind, placebo-controlled study of GSE 100 mg, twice daily, versus placebo. Patients with SAR and skin prick test sensitivity to ragweed were randomized to 8 weeks of active treatment or placebo which was begun before the ragweed pollen season. Outcomes included: daily symptom diary scores recorded by patients, rhinitis quality of life scores at baseline and after 4 and 8 weeks of treatment; and requirements for rescue chlorpheniramine. Safety was monitored with routine laboratory studies.
Over 8 weeks of treatment, no significant differences were observed between active and placebo groups in rhinitis quality of life assessments, symptom diary scores, or requirements for rescue antihistamine. No significant laboratory abnormalities were detected.
This study did not show trends supporting the efficacy of GSE in the treatment of SAR.</description><identifier>ISSN: 1081-1206</identifier><identifier>EISSN: 1534-4436</identifier><identifier>DOI: 10.1016/S1081-1206(10)62008-X</identifier><identifier>PMID: 11926620</identifier><identifier>CODEN: ANAEA3</identifier><language>eng</language><publisher>McLean, VA: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Double-Blind Method ; Female ; Histamine and antagonists. Allergy ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Phytotherapy ; Pilot Projects ; Plant Extracts - adverse effects ; Plant Extracts - therapeutic use ; Rhinitis, Allergic, Seasonal - drug therapy ; Vitis</subject><ispartof>Annals of allergy, asthma, & immunology, 2002-03, Vol.88 (3), p.272-278</ispartof><rights>2002 American College of Allergy, Asthma & Immunology</rights><rights>2002 INIST-CNRS</rights><rights>Copyright American College of Allergy and Immunology Mar 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-20c1a4f3fefaa14324bda30db7d3ef67ce2100a32032c86d1e42ab71228e2f063</citedby><cites>FETCH-LOGICAL-c567t-20c1a4f3fefaa14324bda30db7d3ef67ce2100a32032c86d1e42ab71228e2f063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1081-1206(10)62008-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13559776$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11926620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bernstein, David I.</creatorcontrib><creatorcontrib>Bernstein, Cheryl K.</creatorcontrib><creatorcontrib>Deng, Chunqin</creatorcontrib><creatorcontrib>Murphy, Karen J.</creatorcontrib><creatorcontrib>Bernstein, I.L.</creatorcontrib><creatorcontrib>Bernstein, Jonathan A.</creatorcontrib><creatorcontrib>Shukla, Rakesh</creatorcontrib><title>Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study</title><title>Annals of allergy, asthma, & immunology</title><addtitle>Ann Allergy Asthma Immunol</addtitle><description>Herbal products are widely used by consumers as alternatives to prescription drugs in treating symptoms of allergic rhinitis. However, there have been few placebo-controlled clinical trials that have examined the efficacy or safety of these products. Although grapeseed extract (GSE) is an herbal that is marketed for treating allergic rhinitis, its efficacy is unproven.
The aim of this study was to compare the efficacy and safety of GSE with placebo in the treatment of seasonal allergic rhinitis (SAR).
This was a randomized, double-blind, placebo-controlled study of GSE 100 mg, twice daily, versus placebo. Patients with SAR and skin prick test sensitivity to ragweed were randomized to 8 weeks of active treatment or placebo which was begun before the ragweed pollen season. Outcomes included: daily symptom diary scores recorded by patients, rhinitis quality of life scores at baseline and after 4 and 8 weeks of treatment; and requirements for rescue chlorpheniramine. Safety was monitored with routine laboratory studies.
Over 8 weeks of treatment, no significant differences were observed between active and placebo groups in rhinitis quality of life assessments, symptom diary scores, or requirements for rescue antihistamine. No significant laboratory abnormalities were detected.
This study did not show trends supporting the efficacy of GSE in the treatment of SAR.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Histamine and antagonists. Allergy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Pilot Projects</subject><subject>Plant Extracts - adverse effects</subject><subject>Plant Extracts - therapeutic use</subject><subject>Rhinitis, Allergic, Seasonal - drug therapy</subject><subject>Vitis</subject><issn>1081-1206</issn><issn>1534-4436</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFrFDEUhYMotq7-BCUIin0YzU1mkqkvIqWtQsEHFfoW7mZu2pTZmW2SKe4f8Heb2d1S8KVPNwnfOZybw9hrEB9BgP70E0QLFUihP4A40lKItrp8wg6hUXVV10o_Led75IC9SOlGCAGtVs_ZAcCx1EVzyP6e3mE_YQ7jwEfP8zVx14chOOw5eV-m23AcOp7QU97MzFXENSWijtOfHNFlHoatMEfCvKIhz5THvueJMI1DsSoXilfB8XhdzHNInznydejHzFOeus1L9qwIEr3azwX7fXb66-RbdfHj_PvJ14vKNdrkSgoHWHvlySNCrWS97FCJbmk6RV4bRxKEQCWFkq7VHVAtcWlAypakF1ot2Pud7zqOtxOlbFchOep7HGickjXQNFqox0FoG2MkzODb_8CbcYpl52SlkKZt2hJmwZod5OKYUiRv1zGsMG4sCDvXabd12rmr-Wlbp70sujd782m5ou5Bte-vAO_2AKZSmY84uJAeONU0x8bMKb_sOCqfexco2uQCDY66EMll243hkSj_AH3BvTQ</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Bernstein, David I.</creator><creator>Bernstein, Cheryl K.</creator><creator>Deng, Chunqin</creator><creator>Murphy, Karen J.</creator><creator>Bernstein, I.L.</creator><creator>Bernstein, Jonathan A.</creator><creator>Shukla, Rakesh</creator><general>Elsevier Inc</general><general>American College of Allergy, Asthma, & Immunology</general><general>American College of Allergy and Immunology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study</title><author>Bernstein, David I. ; Bernstein, Cheryl K. ; Deng, Chunqin ; Murphy, Karen J. ; Bernstein, I.L. ; Bernstein, Jonathan A. ; Shukla, Rakesh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-20c1a4f3fefaa14324bda30db7d3ef67ce2100a32032c86d1e42ab71228e2f063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Histamine and antagonists. Allergy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Pilot Projects</topic><topic>Plant Extracts - adverse effects</topic><topic>Plant Extracts - therapeutic use</topic><topic>Rhinitis, Allergic, Seasonal - drug therapy</topic><topic>Vitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernstein, David I.</creatorcontrib><creatorcontrib>Bernstein, Cheryl K.</creatorcontrib><creatorcontrib>Deng, Chunqin</creatorcontrib><creatorcontrib>Murphy, Karen J.</creatorcontrib><creatorcontrib>Bernstein, I.L.</creatorcontrib><creatorcontrib>Bernstein, Jonathan A.</creatorcontrib><creatorcontrib>Shukla, Rakesh</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of allergy, asthma, & immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernstein, David I.</au><au>Bernstein, Cheryl K.</au><au>Deng, Chunqin</au><au>Murphy, Karen J.</au><au>Bernstein, I.L.</au><au>Bernstein, Jonathan A.</au><au>Shukla, Rakesh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study</atitle><jtitle>Annals of allergy, asthma, & immunology</jtitle><addtitle>Ann Allergy Asthma Immunol</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>88</volume><issue>3</issue><spage>272</spage><epage>278</epage><pages>272-278</pages><issn>1081-1206</issn><eissn>1534-4436</eissn><coden>ANAEA3</coden><abstract>Herbal products are widely used by consumers as alternatives to prescription drugs in treating symptoms of allergic rhinitis. However, there have been few placebo-controlled clinical trials that have examined the efficacy or safety of these products. Although grapeseed extract (GSE) is an herbal that is marketed for treating allergic rhinitis, its efficacy is unproven.
The aim of this study was to compare the efficacy and safety of GSE with placebo in the treatment of seasonal allergic rhinitis (SAR).
This was a randomized, double-blind, placebo-controlled study of GSE 100 mg, twice daily, versus placebo. Patients with SAR and skin prick test sensitivity to ragweed were randomized to 8 weeks of active treatment or placebo which was begun before the ragweed pollen season. Outcomes included: daily symptom diary scores recorded by patients, rhinitis quality of life scores at baseline and after 4 and 8 weeks of treatment; and requirements for rescue chlorpheniramine. Safety was monitored with routine laboratory studies.
Over 8 weeks of treatment, no significant differences were observed between active and placebo groups in rhinitis quality of life assessments, symptom diary scores, or requirements for rescue antihistamine. No significant laboratory abnormalities were detected.
This study did not show trends supporting the efficacy of GSE in the treatment of SAR.</abstract><cop>McLean, VA</cop><pub>Elsevier Inc</pub><pmid>11926620</pmid><doi>10.1016/S1081-1206(10)62008-X</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Double-Blind Method Female Histamine and antagonists. Allergy Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Phytotherapy Pilot Projects Plant Extracts - adverse effects Plant Extracts - therapeutic use Rhinitis, Allergic, Seasonal - drug therapy Vitis |
| title | Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study |
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