Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation
Clearance of infectious organisms does not always require polarised Th1 or Th2 responses and it may be advantageous for both Th1 and Th2 responses to be elicited for effective protection against an invading pathogen. It was the aim of this study to investigate oxidised mannan as a possible Th1/Th2 a...
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| Veröffentlicht in: | Vaccine 2002-03, Vol.20 (13), p.1877-1886 |
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| container_issue | 13 |
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| container_title | Vaccine |
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| creator | Stambas, John Pietersz, Geoffrey McKenzie, Ian Nagabhushanam, Vijaya Cheers, Christina |
| description | Clearance of infectious organisms does not always require polarised Th1 or Th2 responses and it may be advantageous for both Th1 and Th2 responses to be elicited for effective protection against an invading pathogen. It was the aim of this study to investigate oxidised mannan as a possible Th1/Th2 adjuvant. Oxidised mannan was conjugated to two candidate antigens and delivered intranasally to mice. Immunisation with the oxidised conjugate resulted in significant antigen specific proliferative responses, IL-2, IFN-γ and IL-4 production when compared to unconjugated controls. |
| doi_str_mv | 10.1016/S0264-410X(02)00039-7 |
| format | Article |
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It was the aim of this study to investigate oxidised mannan as a possible Th1/Th2 adjuvant. Oxidised mannan was conjugated to two candidate antigens and delivered intranasally to mice. Immunisation with the oxidised conjugate resulted in significant antigen specific proliferative responses, IL-2, IFN-γ and IL-4 production when compared to unconjugated controls.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(02)00039-7</identifier><identifier>PMID: 11906778</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvant ; Adjuvants, Immunologic - administration & dosage ; Adjuvants, Immunologic - chemistry ; Administration, Intranasal ; Animals ; Bacterial Toxins ; Bacteriology ; Biological and medical sciences ; Cytokines - biosynthesis ; Dose-Response Relationship, Immunologic ; Female ; Fundamental and applied biological sciences. Psychology ; Heat-Shock Proteins - administration & dosage ; Heat-Shock Proteins - chemistry ; Heat-Shock Proteins - immunology ; Hemolysin Proteins ; Injections, Intraperitoneal ; Listeriosis - immunology ; Lymphocyte Activation - drug effects ; Mannans - administration & dosage ; Mannans - chemistry ; Mannans - immunology ; Mice ; Mice, Inbred BALB C ; Mice, Inbred CBA ; Microbiology ; Oxidation-Reduction ; Oxidised mannan ; Th1 ; Th1 Cells - drug effects ; Th1 Cells - immunology ; Th2 ; Th2 Cells - drug effects ; Th2 Cells - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Virology</subject><ispartof>Vaccine, 2002-03, Vol.20 (13), p.1877-1886</ispartof><rights>2002 Elsevier Science Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-4c2101c02f1642b8b22e3bd1a6ab344f75895c7bbbc0ff0300a3e1993b69aeed3</citedby><cites>FETCH-LOGICAL-c370t-4c2101c02f1642b8b22e3bd1a6ab344f75895c7bbbc0ff0300a3e1993b69aeed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0264-410X(02)00039-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64387</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13531892$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11906778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stambas, John</creatorcontrib><creatorcontrib>Pietersz, Geoffrey</creatorcontrib><creatorcontrib>McKenzie, Ian</creatorcontrib><creatorcontrib>Nagabhushanam, Vijaya</creatorcontrib><creatorcontrib>Cheers, Christina</creatorcontrib><title>Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Clearance of infectious organisms does not always require polarised Th1 or Th2 responses and it may be advantageous for both Th1 and Th2 responses to be elicited for effective protection against an invading pathogen. It was the aim of this study to investigate oxidised mannan as a possible Th1/Th2 adjuvant. Oxidised mannan was conjugated to two candidate antigens and delivered intranasally to mice. Immunisation with the oxidised conjugate resulted in significant antigen specific proliferative responses, IL-2, IFN-γ and IL-4 production when compared to unconjugated controls.</description><subject>Adjuvant</subject><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Adjuvants, Immunologic - chemistry</subject><subject>Administration, Intranasal</subject><subject>Animals</subject><subject>Bacterial Toxins</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Cytokines - biosynthesis</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Heat-Shock Proteins - administration & dosage</subject><subject>Heat-Shock Proteins - chemistry</subject><subject>Heat-Shock Proteins - immunology</subject><subject>Hemolysin Proteins</subject><subject>Injections, Intraperitoneal</subject><subject>Listeriosis - immunology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Mannans - administration & dosage</subject><subject>Mannans - chemistry</subject><subject>Mannans - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred CBA</subject><subject>Microbiology</subject><subject>Oxidation-Reduction</subject><subject>Oxidised mannan</subject><subject>Th1</subject><subject>Th1 Cells - drug effects</subject><subject>Th1 Cells - immunology</subject><subject>Th2</subject><subject>Th2 Cells - drug effects</subject><subject>Th2 Cells - immunology</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1u1DAUBWALgehQeARQNqCyCL2249heVagqP1KlWTBI7CzbuaEeEmewE8S8fd3OiO7oypvvXNv3EPKawgcKtD3_Bqxt6obCjzNg7wGA61o-ISuqJK-ZoOopWf0jJ-RFztuCBKf6OTmhVEMrpVqR7fpv6ELGrhptjDbWQ8gzpjAN-xxita78FLfLTztjrkLsFo_V5oaeb25Y5ffz9CtErBLm3RRzEbYv2eLmZKPNdqjCOC4xZDuHKb4kz3o7ZHx1PE_J909Xm8sv9fX689fLj9e15xLmuvGsfNAD62nbMKccY8hdR21rHW-aXgqlhZfOOQ99DxzAcqRac9dqi9jxU_LuMHeXpt8L5tmMIXscBhtxWrKRVAihWv0opIorKbUq8Oz_UABILbgQhYoD9WnKOWFvdimMNu0NBXNXnLkvzty1YoCZ--KMLLk3xysWN2L3kDo2VcDbI7DZ26EvG_YhPzheqlWaFXdxcFhW_CdgMtkHjB67kNDPppvCI0-5Bck3tls</recordid><startdate>20020315</startdate><enddate>20020315</enddate><creator>Stambas, John</creator><creator>Pietersz, Geoffrey</creator><creator>McKenzie, Ian</creator><creator>Nagabhushanam, Vijaya</creator><creator>Cheers, Christina</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020315</creationdate><title>Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation</title><author>Stambas, John ; Pietersz, Geoffrey ; McKenzie, Ian ; Nagabhushanam, Vijaya ; Cheers, Christina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-4c2101c02f1642b8b22e3bd1a6ab344f75895c7bbbc0ff0300a3e1993b69aeed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adjuvant</topic><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Adjuvants, Immunologic - chemistry</topic><topic>Administration, Intranasal</topic><topic>Animals</topic><topic>Bacterial Toxins</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Cytokines - biosynthesis</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Heat-Shock Proteins - administration & dosage</topic><topic>Heat-Shock Proteins - chemistry</topic><topic>Heat-Shock Proteins - immunology</topic><topic>Hemolysin Proteins</topic><topic>Injections, Intraperitoneal</topic><topic>Listeriosis - immunology</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Mannans - administration & dosage</topic><topic>Mannans - chemistry</topic><topic>Mannans - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred CBA</topic><topic>Microbiology</topic><topic>Oxidation-Reduction</topic><topic>Oxidised mannan</topic><topic>Th1</topic><topic>Th1 Cells - drug effects</topic><topic>Th1 Cells - immunology</topic><topic>Th2</topic><topic>Th2 Cells - drug effects</topic><topic>Th2 Cells - immunology</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stambas, John</creatorcontrib><creatorcontrib>Pietersz, Geoffrey</creatorcontrib><creatorcontrib>McKenzie, Ian</creatorcontrib><creatorcontrib>Nagabhushanam, Vijaya</creatorcontrib><creatorcontrib>Cheers, Christina</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stambas, John</au><au>Pietersz, Geoffrey</au><au>McKenzie, Ian</au><au>Nagabhushanam, Vijaya</au><au>Cheers, Christina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2002-03-15</date><risdate>2002</risdate><volume>20</volume><issue>13</issue><spage>1877</spage><epage>1886</epage><pages>1877-1886</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Clearance of infectious organisms does not always require polarised Th1 or Th2 responses and it may be advantageous for both Th1 and Th2 responses to be elicited for effective protection against an invading pathogen. It was the aim of this study to investigate oxidised mannan as a possible Th1/Th2 adjuvant. Oxidised mannan was conjugated to two candidate antigens and delivered intranasally to mice. Immunisation with the oxidised conjugate resulted in significant antigen specific proliferative responses, IL-2, IFN-γ and IL-4 production when compared to unconjugated controls.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11906778</pmid><doi>10.1016/S0264-410X(02)00039-7</doi><tpages>10</tpages></addata></record> |
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| ispartof | Vaccine, 2002-03, Vol.20 (13), p.1877-1886 |
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| subjects | Adjuvant Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - chemistry Administration, Intranasal Animals Bacterial Toxins Bacteriology Biological and medical sciences Cytokines - biosynthesis Dose-Response Relationship, Immunologic Female Fundamental and applied biological sciences. Psychology Heat-Shock Proteins - administration & dosage Heat-Shock Proteins - chemistry Heat-Shock Proteins - immunology Hemolysin Proteins Injections, Intraperitoneal Listeriosis - immunology Lymphocyte Activation - drug effects Mannans - administration & dosage Mannans - chemistry Mannans - immunology Mice Mice, Inbred BALB C Mice, Inbred CBA Microbiology Oxidation-Reduction Oxidised mannan Th1 Th1 Cells - drug effects Th1 Cells - immunology Th2 Th2 Cells - drug effects Th2 Cells - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Virology |
| title | Oxidised mannan-listeriolysin O conjugates induce Th1/Th2 cytokine responses after intranasal immunisation |
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