Obstetric Complications Correlate with Neurobehavioral and Brain Structural Alterations in Young Relatives at Risk for Schizophrenia
: As complications of pregnancy and birth may be important risk factors for the development of schizophrenia, studying the “roots” of schizophrenia in high‐risk offspring may better elucidate the interface between biology, environment, and susceptibility to illness. Using magnetic resonance imaging...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2003-12, Vol.1008 (1), p.269-275 |
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| container_end_page | 275 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | GILBERT, ANDREW R. MONTROSE, DEBRA M. SAHNI, SARAH D. DIWADKAR, VAIBHAV A. KESHAVAN, MATCHERI S. |
| description | : As complications of pregnancy and birth may be important risk factors for the development of schizophrenia, studying the “roots” of schizophrenia in high‐risk offspring may better elucidate the interface between biology, environment, and susceptibility to illness. Using magnetic resonance imaging (MRI), neurobehavioral assessments and obstetric histories, we found several significant correlations between these multiple factors, suggesting that birth complications may be a nonspecific etiopathogenic risk factor for psychopathology in young relatives at risk for schizophrenia. |
| doi_str_mv | 10.1196/annals.1301.030 |
| format | Article |
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Using magnetic resonance imaging (MRI), neurobehavioral assessments and obstetric histories, we found several significant correlations between these multiple factors, suggesting that birth complications may be a nonspecific etiopathogenic risk factor for psychopathology in young relatives at risk for schizophrenia.</description><subject>Adolescent</subject><subject>Adult</subject><subject>brain</subject><subject>Brain - abnormalities</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>magnetic resonance imaging (MRI)</subject><subject>Obstetric Labor Complications</subject><subject>obstetrics</subject><subject>Pregnancy</subject><subject>Risk Factors</subject><subject>schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - etiology</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv0zAYhi0E2srYmRvyiVs6O3bi-FgqKEhVB8sQ2slynC_ULI0729nYzvvhuEoFR06WPz_vK32PEXpLyZxSWV7oYdB9mFNG6Jww8gLNqOAyK0uWv0QzQoTIKpmzU_Q6hF-E0Lzi4gSdUi5lVUk-Q8-XTYgQvTV46Xb73hodrRtCunkPvY6AH2zc4g2M3jWw1ffWed1jPbT4g9d2wHX0o4njYbjoI_hjPr3cuHH4ia8OLfYeAtYRX9lwizvncW229snttx4Gq9-gV11aA86P5xn6_unj9fJztr5cfVku1plhopSZ0KxhBrpOUFO0FU9T1hCtc8I1lAwYKVtSmarlrDGyFKRoNRQ5SFYJXhDBztD7qXfv3d0IIaqdDQb6Xg_gxqAELYpCCJbAiwk03oXgoVN7b3faPypK1EG8msSrg3iVxKfEu2P12Oyg_ccfTSeAT8CD7eHxf31qc7Oo81KmWDbFbPqm339j2t-qUjBRqB-blVrX16uafuPqK_sDIHai3g</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>GILBERT, ANDREW R.</creator><creator>MONTROSE, DEBRA M.</creator><creator>SAHNI, SARAH D.</creator><creator>DIWADKAR, VAIBHAV A.</creator><creator>KESHAVAN, MATCHERI S.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200312</creationdate><title>Obstetric Complications Correlate with Neurobehavioral and Brain Structural Alterations in Young Relatives at Risk for Schizophrenia</title><author>GILBERT, ANDREW R. ; MONTROSE, DEBRA M. ; SAHNI, SARAH D. ; DIWADKAR, VAIBHAV A. ; KESHAVAN, MATCHERI S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3769-7a3b3ceff71c5d84c373b0aa204ae63e306d08c8d43bc96705dae52e938745073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>brain</topic><topic>Brain - abnormalities</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>magnetic resonance imaging (MRI)</topic><topic>Obstetric Labor Complications</topic><topic>obstetrics</topic><topic>Pregnancy</topic><topic>Risk Factors</topic><topic>schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GILBERT, ANDREW R.</creatorcontrib><creatorcontrib>MONTROSE, DEBRA M.</creatorcontrib><creatorcontrib>SAHNI, SARAH D.</creatorcontrib><creatorcontrib>DIWADKAR, VAIBHAV A.</creatorcontrib><creatorcontrib>KESHAVAN, MATCHERI S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GILBERT, ANDREW R.</au><au>MONTROSE, DEBRA M.</au><au>SAHNI, SARAH D.</au><au>DIWADKAR, VAIBHAV A.</au><au>KESHAVAN, MATCHERI S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obstetric Complications Correlate with Neurobehavioral and Brain Structural Alterations in Young Relatives at Risk for Schizophrenia</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2003-12</date><risdate>2003</risdate><volume>1008</volume><issue>1</issue><spage>269</spage><epage>275</epage><pages>269-275</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: As complications of pregnancy and birth may be important risk factors for the development of schizophrenia, studying the “roots” of schizophrenia in high‐risk offspring may better elucidate the interface between biology, environment, and susceptibility to illness. 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| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 2003-12, Vol.1008 (1), p.269-275 |
| issn | 0077-8923 1749-6632 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Adolescent Adult brain Brain - abnormalities Child Female Humans Magnetic Resonance Imaging magnetic resonance imaging (MRI) Obstetric Labor Complications obstetrics Pregnancy Risk Factors schizophrenia Schizophrenia - diagnosis Schizophrenia - etiology |
| title | Obstetric Complications Correlate with Neurobehavioral and Brain Structural Alterations in Young Relatives at Risk for Schizophrenia |
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