Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas
Heme oxygenase-1 (HO-1) is known as a stress-inducible protein. The present study was designed to investigate the relationship between HO-1 expression levels and clinical features of tongue cancer by using HO-1 responsiveness to stress as a clinical indicator. One-hundred and twelve biopsy samples f...
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| Veröffentlicht in: | Oral oncology 2004, Vol.40 (1), p.21-27 |
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| container_title | Oral oncology |
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| creator | Yanagawa, Toru Omura, Ken Harada, Hiroyuki Nakaso, Kazuhiro Iwasa, Satoshi Koyama, Yumi Onizawa, Kojiro Yusa, Hiroshi Yoshida, Hiroshi |
| description | Heme oxygenase-1 (HO-1) is known as a stress-inducible protein. The present study was designed to investigate the relationship between HO-1 expression levels and clinical features of tongue cancer by using HO-1 responsiveness to stress as a clinical indicator. One-hundred and twelve biopsy samples from tongue squamous cell carcinomas were analyzed semiquantitatively by immunohistochemistry. Correlations between the expression level of HO-1 and the clinical features of tumors were statistically analyzed. Fifty-four cases with surgical confirmation of lymph node metastasis were examined for the association between cervical lymph node metastasis (pN) and other clinical features, including the HO-1 expression level, using logistic regression. The low HO-1 expression group contained significantly more undifferentiated samples (
P=0.04) and pN positive cases (
P=0.01) by univariate analysis. The low HO-1 expression group (odds ratio=8.49; 95% confidence interval=1.64–44.09,
P=0.01) and an endophytic shape (odds ratio=16.79; 95% confidence interval=1.77–159.53,
P=0.01) were significantly associated with an increased risk of developing lymph node metastasis by multivariate analysis. Low HO-1 expression was associated with lymph node metastasis. The expression profile suggests HO-1 could be used clinically as a marker for tumors possessing the potential for lymph node metastasis. This method could prove useful as an adjuvant method to detect lymph node metastasis and may help reduce the number of surgeries by indicating when surgery is unnecessary. |
| doi_str_mv | 10.1016/S1368-8375(03)00128-3 |
| format | Article |
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P=0.04) and pN positive cases (
P=0.01) by univariate analysis. The low HO-1 expression group (odds ratio=8.49; 95% confidence interval=1.64–44.09,
P=0.01) and an endophytic shape (odds ratio=16.79; 95% confidence interval=1.77–159.53,
P=0.01) were significantly associated with an increased risk of developing lymph node metastasis by multivariate analysis. Low HO-1 expression was associated with lymph node metastasis. The expression profile suggests HO-1 could be used clinically as a marker for tumors possessing the potential for lymph node metastasis. This method could prove useful as an adjuvant method to detect lymph node metastasis and may help reduce the number of surgeries by indicating when surgery is unnecessary.</description><identifier>ISSN: 1368-8375</identifier><identifier>EISSN: 1879-0593</identifier><identifier>DOI: 10.1016/S1368-8375(03)00128-3</identifier><identifier>PMID: 14662411</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Carcinoma, Squamous Cell - enzymology ; Female ; Heme Oxygenase (Decyclizing) - metabolism ; Heme Oxygenase-1 ; Humans ; Immunohistochemistry ; Lymph node metastasis ; Lymphatic Metastasis - diagnosis ; Male ; Medical sciences ; Membrane Proteins ; Middle Aged ; Otorhinolaryngology. Stomatology ; Risk Factors ; Squamous cell carcinoma ; Tongue cancer ; Tongue Neoplasms - enzymology ; Tumors</subject><ispartof>Oral oncology, 2004, Vol.40 (1), p.21-27</ispartof><rights>2003 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-218a74ae98ae23699f1634c001c3a6f8a44ee30f5c2a3702782fa91da80d31763</citedby><cites>FETCH-LOGICAL-c482t-218a74ae98ae23699f1634c001c3a6f8a44ee30f5c2a3702782fa91da80d31763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1368837503001283$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15361422$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14662411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yanagawa, Toru</creatorcontrib><creatorcontrib>Omura, Ken</creatorcontrib><creatorcontrib>Harada, Hiroyuki</creatorcontrib><creatorcontrib>Nakaso, Kazuhiro</creatorcontrib><creatorcontrib>Iwasa, Satoshi</creatorcontrib><creatorcontrib>Koyama, Yumi</creatorcontrib><creatorcontrib>Onizawa, Kojiro</creatorcontrib><creatorcontrib>Yusa, Hiroshi</creatorcontrib><creatorcontrib>Yoshida, Hiroshi</creatorcontrib><title>Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas</title><title>Oral oncology</title><addtitle>Oral Oncol</addtitle><description>Heme oxygenase-1 (HO-1) is known as a stress-inducible protein. The present study was designed to investigate the relationship between HO-1 expression levels and clinical features of tongue cancer by using HO-1 responsiveness to stress as a clinical indicator. One-hundred and twelve biopsy samples from tongue squamous cell carcinomas were analyzed semiquantitatively by immunohistochemistry. Correlations between the expression level of HO-1 and the clinical features of tumors were statistically analyzed. Fifty-four cases with surgical confirmation of lymph node metastasis were examined for the association between cervical lymph node metastasis (pN) and other clinical features, including the HO-1 expression level, using logistic regression. The low HO-1 expression group contained significantly more undifferentiated samples (
P=0.04) and pN positive cases (
P=0.01) by univariate analysis. The low HO-1 expression group (odds ratio=8.49; 95% confidence interval=1.64–44.09,
P=0.01) and an endophytic shape (odds ratio=16.79; 95% confidence interval=1.77–159.53,
P=0.01) were significantly associated with an increased risk of developing lymph node metastasis by multivariate analysis. Low HO-1 expression was associated with lymph node metastasis. The expression profile suggests HO-1 could be used clinically as a marker for tumors possessing the potential for lymph node metastasis. This method could prove useful as an adjuvant method to detect lymph node metastasis and may help reduce the number of surgeries by indicating when surgery is unnecessary.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Squamous Cell - enzymology</subject><subject>Female</subject><subject>Heme Oxygenase (Decyclizing) - metabolism</subject><subject>Heme Oxygenase-1</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymph node metastasis</subject><subject>Lymphatic Metastasis - diagnosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Proteins</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Risk Factors</subject><subject>Squamous cell carcinoma</subject><subject>Tongue cancer</subject><subject>Tongue Neoplasms - enzymology</subject><subject>Tumors</subject><issn>1368-8375</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhiNERUvhJ4B8AcEhxeOvOKcKVUArVeoBOFuDMy5GSby1k6r77_F2F_WIZMlzeF77nadp3gA_Aw7m03eQxrZWdvoDlx85B2Fb-aw5Adv1Lde9fF7nf8hx87KUP5xzDZq_aI5BGSMUwEkTLmkilh62tzRjoRYYPWwylRLTzOowRL8U5infR48jG7fT5jeb00BsogVLPbGwFNiS5tuVWLlbcUrrLjGOzGP2cU4TllfNUcCx0OvDfdr8_Prlx8Vle33z7eri83XrlRVLK8Bip5B6iySk6fsARipft_MSTbCoFJHkQXuBsuOisyJgDwNaPkjojDxt3u_f3eR0t1JZ3BTLrgvOVGu5DrRWtlcV1HvQ51RKpuA2OU6Ytw642wl2j4Ldzp7j0j0KdrLm3h4-WH9NNDylDkYr8O4AYKnGQsbZx_LEaWlACVG58z1HVcd9pOyKjzT7ajyTX9yQ4n-q_AXb65hv</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Yanagawa, Toru</creator><creator>Omura, Ken</creator><creator>Harada, Hiroyuki</creator><creator>Nakaso, Kazuhiro</creator><creator>Iwasa, Satoshi</creator><creator>Koyama, Yumi</creator><creator>Onizawa, Kojiro</creator><creator>Yusa, Hiroshi</creator><creator>Yoshida, Hiroshi</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas</title><author>Yanagawa, Toru ; Omura, Ken ; Harada, Hiroyuki ; Nakaso, Kazuhiro ; Iwasa, Satoshi ; Koyama, Yumi ; Onizawa, Kojiro ; Yusa, Hiroshi ; Yoshida, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-218a74ae98ae23699f1634c001c3a6f8a44ee30f5c2a3702782fa91da80d31763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Squamous Cell - enzymology</topic><topic>Female</topic><topic>Heme Oxygenase (Decyclizing) - metabolism</topic><topic>Heme Oxygenase-1</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymph node metastasis</topic><topic>Lymphatic Metastasis - diagnosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Proteins</topic><topic>Middle Aged</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Risk Factors</topic><topic>Squamous cell carcinoma</topic><topic>Tongue cancer</topic><topic>Tongue Neoplasms - enzymology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yanagawa, Toru</creatorcontrib><creatorcontrib>Omura, Ken</creatorcontrib><creatorcontrib>Harada, Hiroyuki</creatorcontrib><creatorcontrib>Nakaso, Kazuhiro</creatorcontrib><creatorcontrib>Iwasa, Satoshi</creatorcontrib><creatorcontrib>Koyama, Yumi</creatorcontrib><creatorcontrib>Onizawa, Kojiro</creatorcontrib><creatorcontrib>Yusa, Hiroshi</creatorcontrib><creatorcontrib>Yoshida, Hiroshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yanagawa, Toru</au><au>Omura, Ken</au><au>Harada, Hiroyuki</au><au>Nakaso, Kazuhiro</au><au>Iwasa, Satoshi</au><au>Koyama, Yumi</au><au>Onizawa, Kojiro</au><au>Yusa, Hiroshi</au><au>Yoshida, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2004</date><risdate>2004</risdate><volume>40</volume><issue>1</issue><spage>21</spage><epage>27</epage><pages>21-27</pages><issn>1368-8375</issn><eissn>1879-0593</eissn><abstract>Heme oxygenase-1 (HO-1) is known as a stress-inducible protein. The present study was designed to investigate the relationship between HO-1 expression levels and clinical features of tongue cancer by using HO-1 responsiveness to stress as a clinical indicator. One-hundred and twelve biopsy samples from tongue squamous cell carcinomas were analyzed semiquantitatively by immunohistochemistry. Correlations between the expression level of HO-1 and the clinical features of tumors were statistically analyzed. Fifty-four cases with surgical confirmation of lymph node metastasis were examined for the association between cervical lymph node metastasis (pN) and other clinical features, including the HO-1 expression level, using logistic regression. The low HO-1 expression group contained significantly more undifferentiated samples (
P=0.04) and pN positive cases (
P=0.01) by univariate analysis. The low HO-1 expression group (odds ratio=8.49; 95% confidence interval=1.64–44.09,
P=0.01) and an endophytic shape (odds ratio=16.79; 95% confidence interval=1.77–159.53,
P=0.01) were significantly associated with an increased risk of developing lymph node metastasis by multivariate analysis. Low HO-1 expression was associated with lymph node metastasis. The expression profile suggests HO-1 could be used clinically as a marker for tumors possessing the potential for lymph node metastasis. This method could prove useful as an adjuvant method to detect lymph node metastasis and may help reduce the number of surgeries by indicating when surgery is unnecessary.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>14662411</pmid><doi>10.1016/S1368-8375(03)00128-3</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oral oncology, 2004, Vol.40 (1), p.21-27 |
| issn | 1368-8375 1879-0593 |
| language | eng |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - enzymology Female Heme Oxygenase (Decyclizing) - metabolism Heme Oxygenase-1 Humans Immunohistochemistry Lymph node metastasis Lymphatic Metastasis - diagnosis Male Medical sciences Membrane Proteins Middle Aged Otorhinolaryngology. Stomatology Risk Factors Squamous cell carcinoma Tongue cancer Tongue Neoplasms - enzymology Tumors |
| title | Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas |
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