Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: The cardiomyopathy trial (CAT)
Patients with idiopathic dilated cardiomyopathy (DCM) and impaired left ventricular ejection fraction have an increased risk of dying suddenly. Patients with recent onset of DCM (< or =9 months) and an ejection fraction < or =30% were randomly assigned to the implantation of an implantable car...
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| Veröffentlicht in: | Circulation (New York, N.Y.) N.Y.), 2002-03, Vol.105 (12), p.1453-1458 |
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| container_title | Circulation (New York, N.Y.) |
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| creator | BÄNSCH, Dietmar ANTZ, Matthias BOCZOR, Sigrid VOLKMER, Marius TEBBENJOHANNS, Jürgen SEIDL, Karlheinz BLOCK, Michael GIETZEN, Frank BERGER, Jürgen KUCK, Karl Heinz |
| description | Patients with idiopathic dilated cardiomyopathy (DCM) and impaired left ventricular ejection fraction have an increased risk of dying suddenly.
Patients with recent onset of DCM (< or =9 months) and an ejection fraction < or =30% were randomly assigned to the implantation of an implantable cardioverter-defibrillator (ICD) or control. The primary end point of the trial was all-cause mortality at 1 year of follow-up. The trial was terminated after the inclusion of 104 patients because the all-cause mortality rate at 1 year did not reach the expected 30% in the control group. In August 2000, the vital status of all patients was updated by contacting patients, relatives, or local registration offices. One hundred four patients were enrolled in the trial: Fifty were assigned to ICD therapy and 54 to the control group. Mean follow-up was 22.8+/-4.3 months, on the basis of investigators' follow-up. After 1 year, 6 patients were dead (4 in the ICD group and 2 in the control group). No sudden death occurred during the first and second years of follow-up. In August 2000, after a mean follow-up of 5.5+/-2.2 years, 30 deaths had occurred (13 in the ICD group and 17 in the control group). Cumulative survival was not significantly different between the two groups (93% and 80% in the control group versus 92% and 86% in the ICD group after 2 and 4 years, respectively).
This trial did not provide evidence in favor of prophylactic ICD implantation in patients with DCM of recent onset and impaired left ventricular ejection fraction. |
| doi_str_mv | 10.1161/01.CIR.0000012350.99718.AD |
| format | Article |
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Patients with recent onset of DCM (< or =9 months) and an ejection fraction < or =30% were randomly assigned to the implantation of an implantable cardioverter-defibrillator (ICD) or control. The primary end point of the trial was all-cause mortality at 1 year of follow-up. The trial was terminated after the inclusion of 104 patients because the all-cause mortality rate at 1 year did not reach the expected 30% in the control group. In August 2000, the vital status of all patients was updated by contacting patients, relatives, or local registration offices. One hundred four patients were enrolled in the trial: Fifty were assigned to ICD therapy and 54 to the control group. Mean follow-up was 22.8+/-4.3 months, on the basis of investigators' follow-up. After 1 year, 6 patients were dead (4 in the ICD group and 2 in the control group). No sudden death occurred during the first and second years of follow-up. In August 2000, after a mean follow-up of 5.5+/-2.2 years, 30 deaths had occurred (13 in the ICD group and 17 in the control group). Cumulative survival was not significantly different between the two groups (93% and 80% in the control group versus 92% and 86% in the ICD group after 2 and 4 years, respectively).
This trial did not provide evidence in favor of prophylactic ICD implantation in patients with DCM of recent onset and impaired left ventricular ejection fraction.</description><identifier>ISSN: 0009-7322</identifier><identifier>EISSN: 1524-4539</identifier><identifier>DOI: 10.1161/01.CIR.0000012350.99718.AD</identifier><identifier>PMID: 11914254</identifier><identifier>CODEN: CIRCAZ</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Biological and medical sciences ; Cardiac Surgical Procedures - adverse effects ; Cardiology. Vascular system ; Cardiomyopathy, Dilated - complications ; Cardiomyopathy, Dilated - mortality ; Cardiomyopathy, Dilated - therapy ; Death, Sudden, Cardiac - etiology ; Death, Sudden, Cardiac - prevention & control ; Defibrillators, Implantable - adverse effects ; Defibrillators, Implantable - statistics & numerical data ; Female ; Follow-Up Studies ; Heart ; Humans ; Male ; Medical sciences ; Middle Aged ; Myocarditis. Cardiomyopathies ; Pilot Projects ; Postoperative Complications - etiology ; Survival Rate ; Tachycardia - etiology ; Tachycardia - prevention & control ; Treatment Outcome ; Ventricular Dysfunction, Left - etiology</subject><ispartof>Circulation (New York, N.Y.), 2002-03, Vol.105 (12), p.1453-1458</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-35758a82cd139a4d91474baac1238e63886fde47fcae32f54b75a79368c1dc653</citedby><cites>FETCH-LOGICAL-c388t-35758a82cd139a4d91474baac1238e63886fde47fcae32f54b75a79368c1dc653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3688,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13597568$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11914254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BÄNSCH, Dietmar</creatorcontrib><creatorcontrib>ANTZ, Matthias</creatorcontrib><creatorcontrib>BOCZOR, Sigrid</creatorcontrib><creatorcontrib>VOLKMER, Marius</creatorcontrib><creatorcontrib>TEBBENJOHANNS, Jürgen</creatorcontrib><creatorcontrib>SEIDL, Karlheinz</creatorcontrib><creatorcontrib>BLOCK, Michael</creatorcontrib><creatorcontrib>GIETZEN, Frank</creatorcontrib><creatorcontrib>BERGER, Jürgen</creatorcontrib><creatorcontrib>KUCK, Karl Heinz</creatorcontrib><title>Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: The cardiomyopathy trial (CAT)</title><title>Circulation (New York, N.Y.)</title><addtitle>Circulation</addtitle><description>Patients with idiopathic dilated cardiomyopathy (DCM) and impaired left ventricular ejection fraction have an increased risk of dying suddenly.
Patients with recent onset of DCM (< or =9 months) and an ejection fraction < or =30% were randomly assigned to the implantation of an implantable cardioverter-defibrillator (ICD) or control. The primary end point of the trial was all-cause mortality at 1 year of follow-up. The trial was terminated after the inclusion of 104 patients because the all-cause mortality rate at 1 year did not reach the expected 30% in the control group. In August 2000, the vital status of all patients was updated by contacting patients, relatives, or local registration offices. One hundred four patients were enrolled in the trial: Fifty were assigned to ICD therapy and 54 to the control group. Mean follow-up was 22.8+/-4.3 months, on the basis of investigators' follow-up. After 1 year, 6 patients were dead (4 in the ICD group and 2 in the control group). No sudden death occurred during the first and second years of follow-up. In August 2000, after a mean follow-up of 5.5+/-2.2 years, 30 deaths had occurred (13 in the ICD group and 17 in the control group). Cumulative survival was not significantly different between the two groups (93% and 80% in the control group versus 92% and 86% in the ICD group after 2 and 4 years, respectively).
This trial did not provide evidence in favor of prophylactic ICD implantation in patients with DCM of recent onset and impaired left ventricular ejection fraction.</description><subject>Biological and medical sciences</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathy, Dilated - complications</subject><subject>Cardiomyopathy, Dilated - mortality</subject><subject>Cardiomyopathy, Dilated - therapy</subject><subject>Death, Sudden, Cardiac - etiology</subject><subject>Death, Sudden, Cardiac - prevention & control</subject><subject>Defibrillators, Implantable - adverse effects</subject><subject>Defibrillators, Implantable - statistics & numerical data</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Pilot Projects</subject><subject>Postoperative Complications - etiology</subject><subject>Survival Rate</subject><subject>Tachycardia - etiology</subject><subject>Tachycardia - prevention & control</subject><subject>Treatment Outcome</subject><subject>Ventricular Dysfunction, Left - etiology</subject><issn>0009-7322</issn><issn>1524-4539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkFtrwyAYhmVsrN3hLwwZbGwXyWKMMfautDsUChuju5avaqgjh07TQf_9bBsozBv19fk-9UHoliQxITl5Skg8mX3GyW6QlLIkFoKTIh5PT9CQsDSLMkbFKRqGcxFxmqYDdOH9d9jmlLNzNCBEkCxl2RC1H87W4LZ47cyvaTrbNrgtsd9obRqswGkLCmsD3QrbBltt23VY25DZCjqjD0xbb_f5doQXK_Mvw52zUOGHyXjxeIXOSqi8ue7nS_T18ryYvEXz99fZZDyPFC2KLqKMswKKVGlCBWQ6PJdnSwAV_luYPDB5qU3GSwWGpiXLlpwBFzQvFNEqZ_QS3R_6rl37szG-k7X1ylQVNKbdeMkJY6mgIoCjA6hc670zpVwfjEiSyJ1umRAZdMujbrnXLcfTUHzT37JZ1kYfS3u_AbjrAfAKqtJBo6w_cpQJzvKC_gGhvInP</recordid><startdate>20020326</startdate><enddate>20020326</enddate><creator>BÄNSCH, Dietmar</creator><creator>ANTZ, Matthias</creator><creator>BOCZOR, Sigrid</creator><creator>VOLKMER, Marius</creator><creator>TEBBENJOHANNS, Jürgen</creator><creator>SEIDL, Karlheinz</creator><creator>BLOCK, Michael</creator><creator>GIETZEN, Frank</creator><creator>BERGER, Jürgen</creator><creator>KUCK, Karl Heinz</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020326</creationdate><title>Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: The cardiomyopathy trial (CAT)</title><author>BÄNSCH, Dietmar ; ANTZ, Matthias ; BOCZOR, Sigrid ; VOLKMER, Marius ; TEBBENJOHANNS, Jürgen ; SEIDL, Karlheinz ; BLOCK, Michael ; GIETZEN, Frank ; BERGER, Jürgen ; KUCK, Karl Heinz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-35758a82cd139a4d91474baac1238e63886fde47fcae32f54b75a79368c1dc653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathy, Dilated - complications</topic><topic>Cardiomyopathy, Dilated - mortality</topic><topic>Cardiomyopathy, Dilated - therapy</topic><topic>Death, Sudden, Cardiac - etiology</topic><topic>Death, Sudden, Cardiac - prevention & control</topic><topic>Defibrillators, Implantable - adverse effects</topic><topic>Defibrillators, Implantable - statistics & numerical data</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Pilot Projects</topic><topic>Postoperative Complications - etiology</topic><topic>Survival Rate</topic><topic>Tachycardia - etiology</topic><topic>Tachycardia - prevention & control</topic><topic>Treatment Outcome</topic><topic>Ventricular Dysfunction, Left - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BÄNSCH, Dietmar</creatorcontrib><creatorcontrib>ANTZ, Matthias</creatorcontrib><creatorcontrib>BOCZOR, Sigrid</creatorcontrib><creatorcontrib>VOLKMER, Marius</creatorcontrib><creatorcontrib>TEBBENJOHANNS, Jürgen</creatorcontrib><creatorcontrib>SEIDL, Karlheinz</creatorcontrib><creatorcontrib>BLOCK, Michael</creatorcontrib><creatorcontrib>GIETZEN, Frank</creatorcontrib><creatorcontrib>BERGER, Jürgen</creatorcontrib><creatorcontrib>KUCK, Karl Heinz</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BÄNSCH, Dietmar</au><au>ANTZ, Matthias</au><au>BOCZOR, Sigrid</au><au>VOLKMER, Marius</au><au>TEBBENJOHANNS, Jürgen</au><au>SEIDL, Karlheinz</au><au>BLOCK, Michael</au><au>GIETZEN, Frank</au><au>BERGER, Jürgen</au><au>KUCK, Karl Heinz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: The cardiomyopathy trial (CAT)</atitle><jtitle>Circulation (New York, N.Y.)</jtitle><addtitle>Circulation</addtitle><date>2002-03-26</date><risdate>2002</risdate><volume>105</volume><issue>12</issue><spage>1453</spage><epage>1458</epage><pages>1453-1458</pages><issn>0009-7322</issn><eissn>1524-4539</eissn><coden>CIRCAZ</coden><abstract>Patients with idiopathic dilated cardiomyopathy (DCM) and impaired left ventricular ejection fraction have an increased risk of dying suddenly.
Patients with recent onset of DCM (< or =9 months) and an ejection fraction < or =30% were randomly assigned to the implantation of an implantable cardioverter-defibrillator (ICD) or control. The primary end point of the trial was all-cause mortality at 1 year of follow-up. The trial was terminated after the inclusion of 104 patients because the all-cause mortality rate at 1 year did not reach the expected 30% in the control group. In August 2000, the vital status of all patients was updated by contacting patients, relatives, or local registration offices. One hundred four patients were enrolled in the trial: Fifty were assigned to ICD therapy and 54 to the control group. Mean follow-up was 22.8+/-4.3 months, on the basis of investigators' follow-up. After 1 year, 6 patients were dead (4 in the ICD group and 2 in the control group). No sudden death occurred during the first and second years of follow-up. In August 2000, after a mean follow-up of 5.5+/-2.2 years, 30 deaths had occurred (13 in the ICD group and 17 in the control group). Cumulative survival was not significantly different between the two groups (93% and 80% in the control group versus 92% and 86% in the ICD group after 2 and 4 years, respectively).
This trial did not provide evidence in favor of prophylactic ICD implantation in patients with DCM of recent onset and impaired left ventricular ejection fraction.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11914254</pmid><doi>10.1161/01.CIR.0000012350.99718.AD</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Cardiac Surgical Procedures - adverse effects Cardiology. Vascular system Cardiomyopathy, Dilated - complications Cardiomyopathy, Dilated - mortality Cardiomyopathy, Dilated - therapy Death, Sudden, Cardiac - etiology Death, Sudden, Cardiac - prevention & control Defibrillators, Implantable - adverse effects Defibrillators, Implantable - statistics & numerical data Female Follow-Up Studies Heart Humans Male Medical sciences Middle Aged Myocarditis. Cardiomyopathies Pilot Projects Postoperative Complications - etiology Survival Rate Tachycardia - etiology Tachycardia - prevention & control Treatment Outcome Ventricular Dysfunction, Left - etiology |
| title | Primary prevention of sudden cardiac death in idiopathic dilated cardiomyopathy: The cardiomyopathy trial (CAT) |
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