Infecton is not specific for bacterial osteo-articular infective pathology
The aim of this study was to re-examine, by retrospective analysis of our case material, the specificity and sensitivity of technetium-99m ciprofloxacin scan in discriminating between infection and other conditions. (99m)Tc-ciprofloxacin scintigraphy was performed in 71 patients: 30 patients referre...
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| Veröffentlicht in: | European journal of nuclear medicine 2002-04, Vol.29 (4), p.530-535 |
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| creator | DUMAREY, Nicolas BLOCKLET, Didier APPELBOOM, Thierry TANT, Laure SCHOUTENS, André |
| description | The aim of this study was to re-examine, by retrospective analysis of our case material, the specificity and sensitivity of technetium-99m ciprofloxacin scan in discriminating between infection and other conditions. (99m)Tc-ciprofloxacin scintigraphy was performed in 71 patients: 30 patients referred for suspicion of osteomyelitis (OM) or septic arthritis (SA) (group 1) and 41 controls (group 2). Imaging was performed at 4 h post injection and, when possible, at 8 or 24 h post injection. Tracer uptake was visually assessed in different joint groups, and in the sites suspicious for infection. Several soft tissue sites were also evaluated. In the group referred for osteo-articular infection, we found a lower specificity (54.5%) than has previously been reported in the literature. Evaluation of tracer uptake at late imaging did not improve discrimination between sterile and non-sterile inflammation. Additionally, articular uptake was seen in many control patients. Infecton uptake in growth cartilage, thyroid gland, vascular pool, lungs, liver and intestines is discussed. |
| doi_str_mv | 10.1007/s00259-001-0749-2 |
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(99m)Tc-ciprofloxacin scintigraphy was performed in 71 patients: 30 patients referred for suspicion of osteomyelitis (OM) or septic arthritis (SA) (group 1) and 41 controls (group 2). Imaging was performed at 4 h post injection and, when possible, at 8 or 24 h post injection. Tracer uptake was visually assessed in different joint groups, and in the sites suspicious for infection. Several soft tissue sites were also evaluated. In the group referred for osteo-articular infection, we found a lower specificity (54.5%) than has previously been reported in the literature. Evaluation of tracer uptake at late imaging did not improve discrimination between sterile and non-sterile inflammation. Additionally, articular uptake was seen in many control patients. Infecton uptake in growth cartilage, thyroid gland, vascular pool, lungs, liver and intestines is discussed.</description><identifier>ISSN: 0340-6997</identifier><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-001-0749-2</identifier><identifier>PMID: 11914892</identifier><identifier>CODEN: EJNMD9</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arthritis, Infectious - diagnostic imaging ; Arthritis, Infectious - pathology ; Bacterial arthritis and osteitis ; Bacterial diseases ; Biological and medical sciences ; Child ; Child, Preschool ; Ciprofloxacin - analogs & derivatives ; Ciprofloxacin - pharmacokinetics ; Diagnosis, Differential ; False Negative Reactions ; False Positive Reactions ; Female ; Fibromyalgia - diagnostic imaging ; Human bacterial diseases ; Humans ; Infant, Newborn ; Infectious diseases ; Intervertebral Disc Displacement - diagnostic imaging ; Joints - diagnostic imaging ; Kidney - metabolism ; Liver - metabolism ; Lumbar Vertebrae - diagnostic imaging ; Male ; Medical sciences ; Middle Aged ; Organotechnetium Compounds - pharmacokinetics ; Osteoarthritis - diagnostic imaging ; Osteomyelitis - diagnostic imaging ; Osteomyelitis - pathology ; Radionuclide Imaging ; Radiopharmaceuticals - pharmacokinetics ; Reference Values ; Sensitivity and Specificity ; Thyroid Gland - metabolism ; Urinary Tract Infections - diagnostic imaging</subject><ispartof>European journal of nuclear medicine, 2002-04, Vol.29 (4), p.530-535</ispartof><rights>2002 INIST-CNRS</rights><rights>Springer-Verlag 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-93161a5c7a50db3a5fdbc349081166021a9d7bcc92725b18c0b3c681bc660e6d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13593073$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11914892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DUMAREY, Nicolas</creatorcontrib><creatorcontrib>BLOCKLET, Didier</creatorcontrib><creatorcontrib>APPELBOOM, Thierry</creatorcontrib><creatorcontrib>TANT, Laure</creatorcontrib><creatorcontrib>SCHOUTENS, André</creatorcontrib><title>Infecton is not specific for bacterial osteo-articular infective pathology</title><title>European journal of nuclear medicine</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>The aim of this study was to re-examine, by retrospective analysis of our case material, the specificity and sensitivity of technetium-99m ciprofloxacin scan in discriminating between infection and other conditions. (99m)Tc-ciprofloxacin scintigraphy was performed in 71 patients: 30 patients referred for suspicion of osteomyelitis (OM) or septic arthritis (SA) (group 1) and 41 controls (group 2). Imaging was performed at 4 h post injection and, when possible, at 8 or 24 h post injection. Tracer uptake was visually assessed in different joint groups, and in the sites suspicious for infection. Several soft tissue sites were also evaluated. In the group referred for osteo-articular infection, we found a lower specificity (54.5%) than has previously been reported in the literature. Evaluation of tracer uptake at late imaging did not improve discrimination between sterile and non-sterile inflammation. Additionally, articular uptake was seen in many control patients. Infecton uptake in growth cartilage, thyroid gland, vascular pool, lungs, liver and intestines is discussed.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis, Infectious - diagnostic imaging</subject><subject>Arthritis, Infectious - pathology</subject><subject>Bacterial arthritis and osteitis</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Ciprofloxacin - analogs & derivatives</subject><subject>Ciprofloxacin - pharmacokinetics</subject><subject>Diagnosis, Differential</subject><subject>False Negative Reactions</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Fibromyalgia - diagnostic imaging</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infectious diseases</subject><subject>Intervertebral Disc Displacement - diagnostic imaging</subject><subject>Joints - diagnostic imaging</subject><subject>Kidney - metabolism</subject><subject>Liver - metabolism</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Organotechnetium Compounds - pharmacokinetics</subject><subject>Osteoarthritis - diagnostic imaging</subject><subject>Osteomyelitis - diagnostic imaging</subject><subject>Osteomyelitis - pathology</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Thyroid Gland - metabolism</subject><subject>Urinary Tract Infections - diagnostic imaging</subject><issn>0340-6997</issn><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkE1L7DAUhoMoOn78gLu5FEF30XOapmmWIlcdEdzoOqSnqUY6zZi0F_z3RmdAcHUW53lfXh7G_iBcIIC6TACl1BwAOahK83KHLbBGzRU0epctQFTAa63VATtM6Q0AqkrIfXaAqLFqdLlg98uxdzSFsfCpGMNUpLUj33sq-hCL1tLkordDEdLkArdx8jQPNhb-O-b_u2Jtp9cwhJePY7bX2yG5k-09Ys83_56u7_jD4-3y-uqBk5DVxLXIE60kZSV0rbCy71oSlYYGsa6hRKs71RLpUpWyxYagFVQ32FL-uroTR-x807uO4X12aTIrn8gNgx1dmJNRKCVgIzJ4-gt8C3Mc8zZTYlXLrEBlCDcQxZBSdL1ZR7-y8cMgmC_LZmPZZMvmy7Ipc-bvtnhuV677SWy1ZuBsC9hEduijHcmnH05ILUAJ8Qn2PYP6</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>DUMAREY, Nicolas</creator><creator>BLOCKLET, Didier</creator><creator>APPELBOOM, Thierry</creator><creator>TANT, Laure</creator><creator>SCHOUTENS, André</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Infecton is not specific for bacterial osteo-articular infective pathology</title><author>DUMAREY, Nicolas ; BLOCKLET, Didier ; APPELBOOM, Thierry ; TANT, Laure ; SCHOUTENS, André</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-93161a5c7a50db3a5fdbc349081166021a9d7bcc92725b18c0b3c681bc660e6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthritis, Infectious - diagnostic imaging</topic><topic>Arthritis, Infectious - pathology</topic><topic>Bacterial arthritis and osteitis</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Ciprofloxacin - analogs & derivatives</topic><topic>Ciprofloxacin - pharmacokinetics</topic><topic>Diagnosis, Differential</topic><topic>False Negative Reactions</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>Fibromyalgia - diagnostic imaging</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infectious diseases</topic><topic>Intervertebral Disc Displacement - diagnostic imaging</topic><topic>Joints - diagnostic imaging</topic><topic>Kidney - metabolism</topic><topic>Liver - metabolism</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Organotechnetium Compounds - pharmacokinetics</topic><topic>Osteoarthritis - diagnostic imaging</topic><topic>Osteomyelitis - diagnostic imaging</topic><topic>Osteomyelitis - pathology</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Reference Values</topic><topic>Sensitivity and Specificity</topic><topic>Thyroid Gland - metabolism</topic><topic>Urinary Tract Infections - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DUMAREY, Nicolas</creatorcontrib><creatorcontrib>BLOCKLET, Didier</creatorcontrib><creatorcontrib>APPELBOOM, Thierry</creatorcontrib><creatorcontrib>TANT, Laure</creatorcontrib><creatorcontrib>SCHOUTENS, André</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DUMAREY, Nicolas</au><au>BLOCKLET, Didier</au><au>APPELBOOM, Thierry</au><au>TANT, Laure</au><au>SCHOUTENS, André</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infecton is not specific for bacterial osteo-articular infective pathology</atitle><jtitle>European journal of nuclear medicine</jtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>29</volume><issue>4</issue><spage>530</spage><epage>535</epage><pages>530-535</pages><issn>0340-6997</issn><issn>1619-7070</issn><eissn>1619-7089</eissn><coden>EJNMD9</coden><abstract>The aim of this study was to re-examine, by retrospective analysis of our case material, the specificity and sensitivity of technetium-99m ciprofloxacin scan in discriminating between infection and other conditions. (99m)Tc-ciprofloxacin scintigraphy was performed in 71 patients: 30 patients referred for suspicion of osteomyelitis (OM) or septic arthritis (SA) (group 1) and 41 controls (group 2). Imaging was performed at 4 h post injection and, when possible, at 8 or 24 h post injection. Tracer uptake was visually assessed in different joint groups, and in the sites suspicious for infection. Several soft tissue sites were also evaluated. In the group referred for osteo-articular infection, we found a lower specificity (54.5%) than has previously been reported in the literature. Evaluation of tracer uptake at late imaging did not improve discrimination between sterile and non-sterile inflammation. Additionally, articular uptake was seen in many control patients. Infecton uptake in growth cartilage, thyroid gland, vascular pool, lungs, liver and intestines is discussed.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11914892</pmid><doi>10.1007/s00259-001-0749-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Arthritis, Infectious - diagnostic imaging Arthritis, Infectious - pathology Bacterial arthritis and osteitis Bacterial diseases Biological and medical sciences Child Child, Preschool Ciprofloxacin - analogs & derivatives Ciprofloxacin - pharmacokinetics Diagnosis, Differential False Negative Reactions False Positive Reactions Female Fibromyalgia - diagnostic imaging Human bacterial diseases Humans Infant, Newborn Infectious diseases Intervertebral Disc Displacement - diagnostic imaging Joints - diagnostic imaging Kidney - metabolism Liver - metabolism Lumbar Vertebrae - diagnostic imaging Male Medical sciences Middle Aged Organotechnetium Compounds - pharmacokinetics Osteoarthritis - diagnostic imaging Osteomyelitis - diagnostic imaging Osteomyelitis - pathology Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics Reference Values Sensitivity and Specificity Thyroid Gland - metabolism Urinary Tract Infections - diagnostic imaging |
| title | Infecton is not specific for bacterial osteo-articular infective pathology |
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