The effects of an orally administered cholinergic agonist on REM sleep in major depression

Centrally active cholinergic agents such as arecoline and physostigmine shorten rapid eye movement (REM) latency, reduce REM interval times, or both and do so preferentially in patients with depression. We tested an orally administered cholinergic agonist (donepezil HCL 10 mg [Aricept]) to determine...

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Veröffentlicht in:	Biological psychiatry (1969) 2002-03, Vol.51 (6), p.457-462
Hauptverfasser:	PERLIS, Michael L, SMITH, Michael T, ORFF, Henry J, ANDREWS, Patrick J, GILLIN, J. Christian, GILES, Donna E
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Adult and adolescent clinical studies Biological and medical sciences Cholinergic Agents - administration & dosage Cholinesterase Inhibitors - administration & dosage Depression Depressive Disorder, Major - diagnosis Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics Donepezil Female Humans Indans - administration & dosage Male Medical sciences Middle Aged Mood disorders Piperidines - administration & dosage Polysomnography Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reaction Time - drug effects Single-Blind Method Sleep, REM - drug effects Sleep, REM - genetics
Online-Zugang:	Volltext
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