Differential membrane targeting of the SERCA and PMCA calcium pumps: experiments with recombinant chimeras

ABSTRACT Structural features underlying retention of the SERCA pump in intracellular compartments and the sorting of the PMCA pump to the plasma membrane are not known. The biochemical properties of the two pumps suggest that their differential localization may respond to specific functional demands...

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Veröffentlicht in:	The FASEB journal 2002-04, Vol.16 (6), p.519-528
Hauptverfasser:	Guerini, Danilo, Guidi, Fabrizio, Carafoli, Ernesto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Biotinylation Calcium-Transporting ATPases - analysis Calcium-Transporting ATPases - chemistry Calcium-Transporting ATPases - genetics Calcium-Transporting ATPases - metabolism Cation Transport Proteins Cell Membrane - enzymology Cells, Cultured chimeric proteins COS Cells Endoplasmic Reticulum - enzymology ER/SR Ca2+ pump Intracellular Membranes - enzymology Microscopy, Fluorescence plasma membrane Ca2+ pump Plasma Membrane Calcium-Transporting ATPases Protein Structure, Tertiary Protein Transport Recombinant Fusion Proteins - analysis Sarcoplasmic Reticulum Calcium-Transporting ATPases Spodoptera - genetics Transfection
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