Arachidonate release and eicosanoid generation by group IIE phospholipase A(2)

The heparin-binding group II subfamily of secretory phospholipase A(2)s (sPLA(2)s), such as sPLA(2)-IIA and -IID, augments stimulus-induced arachidonic acid (AA) release through the cellular heparan sulfate proteoglycan (HSPG)-dependent pathway when transfected into HEK293 cells. Here we show that t...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002-04, Vol.292 (3), p.689-696
Hauptverfasser:	Murakami, Makoto, Yoshihara, Kumiko, Shimbara, Satoko, Lambeau, Gerard, Singer, Alan, Gelb, Michael H, Sawada, Masatsugu, Inagaki, Naoki, Nagai, Hiroichi, Kudo, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants - pharmacology Arachidonic Acid - metabolism Cell Line Eicosanoids - metabolism Gene Expression Regulation Group II Phospholipases A2 Heparin - pharmacology Humans Inflammation - physiopathology Isoenzymes - metabolism Mast Cells - metabolism Mast Cells - secretion Mice Microscopy, Confocal Phospholipases A - genetics Phospholipases A - metabolism Protein Binding
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