Biocompatibility of micro- and nano-particles in the colon. Part II
Pathological colonic tissues were investigated with an Environmental Scanning Electron Microscope technique to verify the presence of inorganic, non-biodegradable pollutants, i.e. micro- and nano-debris of exogenous origin, after debris in liver and kidney had been discovered. In all, 18 samples of...
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| Veröffentlicht in: | Biomaterials 2004-02, Vol.25 (3), p.385-392 |
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| creator | Gatti, Antonietta M. |
| description | Pathological colonic tissues were investigated with an Environmental Scanning Electron Microscope technique to verify the presence of inorganic, non-biodegradable pollutants, i.e. micro- and nano-debris of exogenous origin, after debris in liver and kidney had been discovered.
In all, 18 samples of colon tissues affected by cancer and Crohn's disease were evaluated and found in all the cases to contain micro- and nano-particles. Their chemistry, detected with an X-ray microprobe, indicated a heterogeneous nature, whereas the size of the particles was homogeneous. Three control samples of healthy, young, cadavers were analysed and showed the absence of debris within the normal, healthy colon mucosa.
The study reveals the presence of particulate debris, generally considered as biocompatible, in pathological specimens of human colon. The findings suggest a possible link between the presence of such particles and the underlying pathology in the cases analysed. |
| doi_str_mv | 10.1016/S0142-9612(03)00537-4 |
| format | Article |
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In all, 18 samples of colon tissues affected by cancer and Crohn's disease were evaluated and found in all the cases to contain micro- and nano-particles. Their chemistry, detected with an X-ray microprobe, indicated a heterogeneous nature, whereas the size of the particles was homogeneous. Three control samples of healthy, young, cadavers were analysed and showed the absence of debris within the normal, healthy colon mucosa.
The study reveals the presence of particulate debris, generally considered as biocompatible, in pathological specimens of human colon. The findings suggest a possible link between the presence of such particles and the underlying pathology in the cases analysed.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(03)00537-4</identifier><identifier>PMID: 14585686</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Biocompatibility ; Biocompatible Materials - pharmacology ; Colon - chemistry ; Colon - metabolism ; Colon - pathology ; Colonic Neoplasms - metabolism ; Crohn Disease - metabolism ; Humans ; Intestinal Mucosa - pathology ; Kidney - metabolism ; Liver - metabolism ; Microscopy, Electron, Scanning ; Microspheres ; Nano-particles ; Nano-pathology ; Nanotechnology ; Silicate ; Silicates - analysis ; Stainless Steel - analysis ; Sulfur - chemistry ; Wear debris ; Zirconium - analysis</subject><ispartof>Biomaterials, 2004-02, Vol.25 (3), p.385-392</ispartof><rights>2003 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-277144138d3a69a70697f52c088866e6f2066b67992199052cb6a4ca2bf8f1503</citedby><cites>FETCH-LOGICAL-c458t-277144138d3a69a70697f52c088866e6f2066b67992199052cb6a4ca2bf8f1503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961203005374$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14585686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gatti, Antonietta M.</creatorcontrib><title>Biocompatibility of micro- and nano-particles in the colon. Part II</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Pathological colonic tissues were investigated with an Environmental Scanning Electron Microscope technique to verify the presence of inorganic, non-biodegradable pollutants, i.e. micro- and nano-debris of exogenous origin, after debris in liver and kidney had been discovered.
In all, 18 samples of colon tissues affected by cancer and Crohn's disease were evaluated and found in all the cases to contain micro- and nano-particles. Their chemistry, detected with an X-ray microprobe, indicated a heterogeneous nature, whereas the size of the particles was homogeneous. Three control samples of healthy, young, cadavers were analysed and showed the absence of debris within the normal, healthy colon mucosa.
The study reveals the presence of particulate debris, generally considered as biocompatible, in pathological specimens of human colon. The findings suggest a possible link between the presence of such particles and the underlying pathology in the cases analysed.</description><subject>Biocompatibility</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Colon - chemistry</subject><subject>Colon - metabolism</subject><subject>Colon - pathology</subject><subject>Colonic Neoplasms - metabolism</subject><subject>Crohn Disease - metabolism</subject><subject>Humans</subject><subject>Intestinal Mucosa - pathology</subject><subject>Kidney - metabolism</subject><subject>Liver - metabolism</subject><subject>Microscopy, Electron, Scanning</subject><subject>Microspheres</subject><subject>Nano-particles</subject><subject>Nano-pathology</subject><subject>Nanotechnology</subject><subject>Silicate</subject><subject>Silicates - analysis</subject><subject>Stainless Steel - analysis</subject><subject>Sulfur - chemistry</subject><subject>Wear debris</subject><subject>Zirconium - analysis</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMo7rr6E5ScRA9dkzSfJ9HFj4UFBfUc0jTFSNvUpCvsv7f7gR73NMzwzLzMA8A5RlOMML95Q5iSTHFMrlB-jRDLRUYPwBhLITOmEDsE4z9kBE5S-kJDjyg5BiNMmWRc8jGY3ftgQ9OZ3he-9v0Khgo23saQQdOWsDVtyDoTe29rl6BvYf_poA11aKfwdZjD-fwUHFWmTu5sVyfg4_HhffacLV6e5rO7RWaHuD4jQmBKcS7L3HBlBOJKVIxYJKXk3PGKIM4LLpQiWA0PEFtwQ60hRSUrzFA-AZfbu10M30uXet34ZF1dm9aFZdICM6oEpXtBLBRlCosBZFtw-Del6CrdRd-YuNIY6bVmvdGs1w41yvVGs14HXOwClkXjyv-tndcBuN0CbvDx413UyXrXWlf66Gyvy-D3RPwC5H2Jcg</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Gatti, Antonietta M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Biocompatibility of micro- and nano-particles in the colon. Part II</title><author>Gatti, Antonietta M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-277144138d3a69a70697f52c088866e6f2066b67992199052cb6a4ca2bf8f1503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Biocompatibility</topic><topic>Biocompatible Materials - pharmacology</topic><topic>Colon - chemistry</topic><topic>Colon - metabolism</topic><topic>Colon - pathology</topic><topic>Colonic Neoplasms - metabolism</topic><topic>Crohn Disease - metabolism</topic><topic>Humans</topic><topic>Intestinal Mucosa - pathology</topic><topic>Kidney - metabolism</topic><topic>Liver - metabolism</topic><topic>Microscopy, Electron, Scanning</topic><topic>Microspheres</topic><topic>Nano-particles</topic><topic>Nano-pathology</topic><topic>Nanotechnology</topic><topic>Silicate</topic><topic>Silicates - analysis</topic><topic>Stainless Steel - analysis</topic><topic>Sulfur - chemistry</topic><topic>Wear debris</topic><topic>Zirconium - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gatti, Antonietta M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gatti, Antonietta M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biocompatibility of micro- and nano-particles in the colon. Part II</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>25</volume><issue>3</issue><spage>385</spage><epage>392</epage><pages>385-392</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Pathological colonic tissues were investigated with an Environmental Scanning Electron Microscope technique to verify the presence of inorganic, non-biodegradable pollutants, i.e. micro- and nano-debris of exogenous origin, after debris in liver and kidney had been discovered.
In all, 18 samples of colon tissues affected by cancer and Crohn's disease were evaluated and found in all the cases to contain micro- and nano-particles. Their chemistry, detected with an X-ray microprobe, indicated a heterogeneous nature, whereas the size of the particles was homogeneous. Three control samples of healthy, young, cadavers were analysed and showed the absence of debris within the normal, healthy colon mucosa.
The study reveals the presence of particulate debris, generally considered as biocompatible, in pathological specimens of human colon. The findings suggest a possible link between the presence of such particles and the underlying pathology in the cases analysed.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>14585686</pmid><doi>10.1016/S0142-9612(03)00537-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2004-02, Vol.25 (3), p.385-392 |
| issn | 0142-9612 1878-5905 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biocompatibility Biocompatible Materials - pharmacology Colon - chemistry Colon - metabolism Colon - pathology Colonic Neoplasms - metabolism Crohn Disease - metabolism Humans Intestinal Mucosa - pathology Kidney - metabolism Liver - metabolism Microscopy, Electron, Scanning Microspheres Nano-particles Nano-pathology Nanotechnology Silicate Silicates - analysis Stainless Steel - analysis Sulfur - chemistry Wear debris Zirconium - analysis |
| title | Biocompatibility of micro- and nano-particles in the colon. Part II |
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