Molecular characterization of arrestin family members in the malaria vector mosquito, Anopheles gambiae
Olfaction influences many insect behaviours including mate seeking and host selection. The molecular machinery underlying insect olfactory systems is a G protein‐coupled receptor pathway that, in addition to activation, requires adaptation for olfactory sensitivity and discrimination. We have previo...
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| Veröffentlicht in: | Insect molecular biology 2003-12, Vol.12 (6), p.641-650 |
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| container_title | Insect molecular biology |
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| creator | Merrill, C. E. Pitts, R. J. Zwiebel, L. J. |
| description | Olfaction influences many insect behaviours including mate seeking and host selection. The molecular machinery underlying insect olfactory systems is a G protein‐coupled receptor pathway that, in addition to activation, requires adaptation for olfactory sensitivity and discrimination. We have previously identified ARR1 (henceforth AgARR1), a sensory arrestin from the malaria vector mosquito Anopheles gambiae that has been postulated to modulate olfactory adaptation. This report describes three additional arrestin family members including ARR2 (henceforth AgARR2), which is similar to previously characterized insect sensory arrestins and is expressed at significantly higher levels in the antennae of male vs. female A. gambiae mosquitoes. This finding is consistent with the hypothesis that AgARR2 may be important for the regulation of olfactory‐driven behaviours particular to male mosquitoes. |
| doi_str_mv | 10.1046/j.1365-2583.2003.00450.x |
| format | Article |
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E.</creatorcontrib><creatorcontrib>Pitts, R. J.</creatorcontrib><creatorcontrib>Zwiebel, L. J.</creatorcontrib><title>Molecular characterization of arrestin family members in the malaria vector mosquito, Anopheles gambiae</title><title>Insect molecular biology</title><addtitle>Insect Mol Biol</addtitle><description>Olfaction influences many insect behaviours including mate seeking and host selection. The molecular machinery underlying insect olfactory systems is a G protein‐coupled receptor pathway that, in addition to activation, requires adaptation for olfactory sensitivity and discrimination. We have previously identified ARR1 (henceforth AgARR1), a sensory arrestin from the malaria vector mosquito Anopheles gambiae that has been postulated to modulate olfactory adaptation. This report describes three additional arrestin family members including ARR2 (henceforth AgARR2), which is similar to previously characterized insect sensory arrestins and is expressed at significantly higher levels in the antennae of male vs. female A. gambiae mosquitoes. This finding is consistent with the hypothesis that AgARR2 may be important for the regulation of olfactory‐driven behaviours particular to male mosquitoes.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Anopheles</subject><subject>Anopheles - genetics</subject><subject>Anopheles gambiae</subject><subject>arrestin</subject><subject>Arrestins - genetics</subject><subject>Culicidae</subject><subject>DNA Primers</subject><subject>Female</subject><subject>G-protein</subject><subject>Gene Expression</subject><subject>Gene Library</subject><subject>malaria</subject><subject>Male</subject><subject>Molecular Sequence Data</subject><subject>olfactory</subject><subject>Phylogeny</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sequence Alignment</subject><subject>Sequence Analysis, DNA</subject><subject>Sex Factors</subject><subject>Smell - genetics</subject><issn>0962-1075</issn><issn>1365-2583</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFvEzEQhS0EomnhLyCfOLHL2F57bYlLqUqolAKCIrhZjjPbOOzGqb1LE349GxKVI5w88rzv2XqPEMqgZFCp16uSCSULLrUoOYAoASoJ5fYRmTwsHpMJGMULBrU8Iac5rwBAG2WekhNWGa0MlxNyex1b9EPrEvVLl5zvMYVfrg9xTWNDXUqY-7CmjetCu6MddnNMmY43_RJp50YwOPoTfR8T7WK-G0IfX9HzddwsscVMb103Dw6fkSeNazM-P55n5Ou7y5uL98Xs4_Tq4nxW-MoYKGRt-AK8rrHGuVKgKm_AC-UE187whgl0Cy1qrRV3nCnOFdMguAHDDCy4OCMvD76bFO-G8e-2C9lj27o1xiHbmsnKCCn-KRxtuRS1GoX6IPQp5pywsZsUOpd2loHdt2FXdh-63Ydu923YP23Y7Yi-OL4xzDtc_AWP8Y-CNwfBfWhx99_G9ur67TiMeHHAQ-5x-4C79MOqWtTSfvswtV9uPn3Xejqzn8VvJeOnLw</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>Merrill, C. E.</creator><creator>Pitts, R. J.</creator><creator>Zwiebel, L. J.</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>200312</creationdate><title>Molecular characterization of arrestin family members in the malaria vector mosquito, Anopheles gambiae</title><author>Merrill, C. E. ; Pitts, R. J. ; Zwiebel, L. 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E.</creatorcontrib><creatorcontrib>Pitts, R. J.</creatorcontrib><creatorcontrib>Zwiebel, L. 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E.</au><au>Pitts, R. J.</au><au>Zwiebel, L. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular characterization of arrestin family members in the malaria vector mosquito, Anopheles gambiae</atitle><jtitle>Insect molecular biology</jtitle><addtitle>Insect Mol Biol</addtitle><date>2003-12</date><risdate>2003</risdate><volume>12</volume><issue>6</issue><spage>641</spage><epage>650</epage><pages>641-650</pages><issn>0962-1075</issn><eissn>1365-2583</eissn><abstract>Olfaction influences many insect behaviours including mate seeking and host selection. The molecular machinery underlying insect olfactory systems is a G protein‐coupled receptor pathway that, in addition to activation, requires adaptation for olfactory sensitivity and discrimination. We have previously identified ARR1 (henceforth AgARR1), a sensory arrestin from the malaria vector mosquito Anopheles gambiae that has been postulated to modulate olfactory adaptation. 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| ispartof | Insect molecular biology, 2003-12, Vol.12 (6), p.641-650 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amino Acid Sequence Animals Anopheles Anopheles - genetics Anopheles gambiae arrestin Arrestins - genetics Culicidae DNA Primers Female G-protein Gene Expression Gene Library malaria Male Molecular Sequence Data olfactory Phylogeny Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Analysis, DNA Sex Factors Smell - genetics |
| title | Molecular characterization of arrestin family members in the malaria vector mosquito, Anopheles gambiae |
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