Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation

Deregulation of the intracellular Ca2+ homeostasis by NMDA receptor activation leads to neuronal cell death. Induction of the mitochondrial permeability transition pore (MPT) by Ca2+ is a critical event in mediating cell death. In this study, we used fluorescent Ca2+ indicators to investigate the ef...

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Veröffentlicht in:	Journal of neurochemistry 2002-02, Vol.80 (3), p.531-538
Hauptverfasser:	Alano, Conrad C., Beutner, Gisela, Dirksen, Robert T., Gross, Robert A., Sheu, Shey‐Shing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry and metabolism Biological and medical sciences calcium Calcium - metabolism cell death Cell Death - drug effects Cell Death - physiology Cells, Cultured Central nervous system Corpus Striatum - cytology Cyclosporine - pharmacology Excitatory Amino Acid Agonists - pharmacology Fundamental and applied biological sciences. Psychology Microscopy, Confocal mitochondria Mitochondria - metabolism N-Methylaspartate - pharmacology Neurons - cytology Neurons - metabolism NMDA permeability transition Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism striatal neurons Vertebrates: nervous system and sense organs
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