NADPH–Oxidase may Contribute to IL-12 Production in Macrophages Stimulated with CpG Phosphorothioate Oligodeoxynucleotides

CpG oligodeoxynucleotides (CpG-ODN) could be expectes to act as an adjuvant for humoral and cellular immunities. The aim of this study was to clarify the mechanism of macrophage activation induced by CpG-ODN. Macrophage activation by CpG-ODN was evaluated by measurement of IL-12 secretion. IL-12 sec...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2002, Vol.25(3), pp.351-355
Hauptverfasser:	Aramaki, Yukihiko, Yotsumoto, Satoshi, Watanabe, Hiroyuki, Tsuchiya, Seishi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Base Sequence Biological and medical sciences CpG DNA Primers Fundamental and applied biological sciences. Psychology Fundamental immunology IL-12 Immunobiology Interleukin-12 - biosynthesis Lymphokines, interleukins ( function, expression) macrophage Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism NADPH Oxidases - metabolism NADPH–oxidase NF-kappa B - metabolism Organophosphorus Compounds - pharmacology Reactive Oxygen Species Regulatory factors and their cellular receptors ROS Thionucleotides - pharmacology
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