Monitoring of idebenone treatment in patients with Friedreich's ataxia by high-pressure liquid chromatography with electrochemical detection

Idebenone is a quinone analog that is applied in the treatment of several neurological disorders including Friedreich ataxia and mitochondrial encephalomyopathies. Our aim was to develop an easy and sensitive analytical HPLC-procedure for the determination of idebenone in the serum of patients treat...

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Veröffentlicht in:	Journal of neuroscience methods 2002-03, Vol.115 (1), p.63-66
Hauptverfasser:	Artuch, Rafael, Colomé, Catrina, Vilaseca, Maria Antònia, Aracil, Asun, Pineda, Mercè
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antioxidants - pharmacokinetics Benzoquinones - blood Benzoquinones - pharmacokinetics Biological and medical sciences Child Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Electrochemical detection Electrochemistry - instrumentation Electrochemistry - methods Female Friedreich ataxia Friedreich Ataxia - drug therapy Fundamental and applied biological sciences. Psychology General aspects. Models. Methods HPLC Humans Idebenone Male Monitoring, Physiologic - instrumentation Monitoring, Physiologic - methods Pediatric patients Pharmacology, Clinical - instrumentation Pharmacology, Clinical - methods Ubiquinone Ubiquinone - analogs & derivatives Vertebrates: nervous system and sense organs
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