Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications
A key aspect of social cognition is the ability to infer other people's mental states, thoughts and feelings; referred to as 'theory of mind' (ToM). We tested the hypothesis that the changes in personality and behaviour seen in frontal variant frontotemporal dementia (fvFTD) may refle...
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Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 2002-04, Vol.125 (Pt 4), p.752-764 |
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description | A key aspect of social cognition is the ability to infer other people's mental states, thoughts and feelings; referred to as 'theory of mind' (ToM). We tested the hypothesis that the changes in personality and behaviour seen in frontal variant frontotemporal dementia (fvFTD) may reflect impairment in this cognitive domain. Tests of ToM, executive and general neuropsychological ability were given to 19 fvFTD patients, a comparison group of Alzheimer's disease patients (n = 12) and matched healthy controls (n = 16). Neuropsychiatric assessment was undertaken using the Neuropsychiatric Inventory (NPI). Patients with fvFTD were impaired on all tests of ToM (first-order false belief; second-order false belief; faux pas detection; and Reading the Mind in the Eyes), but had no difficulty with control questions designed to test general comprehension and memory. By contrast, the Alzheimer's disease group failed only one ToM task (second-order false belief), which places heavy demands on working memory. Performance on the faux pas test revealed a double dissociation, with the fvFTD group showing deficits on ToM-based questions and the Alzheimer's disease group failing memory-based questions only. Rank order of the fvFTD patients according to the magnitude of impairment on tests of ToM and their degree of frontal atrophy showed a striking concordance between ToM performances and ventromedial frontal damage. There was a significant correlation between the NPI score and more sophisticated tests of ToM in the fvFTD group. This study supports the hypothesis that patients with fvFTD, but not those with Alzheimer's disease, are impaired on tests of ToM, and may explain some of the abnormalities in interpersonal behaviour that characterize fvFTD. |
doi_str_mv | 10.1093/brain/awf079 |
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We tested the hypothesis that the changes in personality and behaviour seen in frontal variant frontotemporal dementia (fvFTD) may reflect impairment in this cognitive domain. Tests of ToM, executive and general neuropsychological ability were given to 19 fvFTD patients, a comparison group of Alzheimer's disease patients (n = 12) and matched healthy controls (n = 16). Neuropsychiatric assessment was undertaken using the Neuropsychiatric Inventory (NPI). Patients with fvFTD were impaired on all tests of ToM (first-order false belief; second-order false belief; faux pas detection; and Reading the Mind in the Eyes), but had no difficulty with control questions designed to test general comprehension and memory. By contrast, the Alzheimer's disease group failed only one ToM task (second-order false belief), which places heavy demands on working memory. Performance on the faux pas test revealed a double dissociation, with the fvFTD group showing deficits on ToM-based questions and the Alzheimer's disease group failing memory-based questions only. Rank order of the fvFTD patients according to the magnitude of impairment on tests of ToM and their degree of frontal atrophy showed a striking concordance between ToM performances and ventromedial frontal damage. There was a significant correlation between the NPI score and more sophisticated tests of ToM in the fvFTD group. This study supports the hypothesis that patients with fvFTD, but not those with Alzheimer's disease, are impaired on tests of ToM, and may explain some of the abnormalities in interpersonal behaviour that characterize fvFTD.</description><identifier>ISSN: 0006-8950</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/awf079</identifier><identifier>PMID: 11912109</identifier><identifier>CODEN: BRAIAK</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Aged ; Alzheimer Disease - pathology ; Alzheimer Disease - physiopathology ; Alzheimer Disease - psychology ; Biological and medical sciences ; Cognition - physiology ; Cognition Disorders - pathology ; Cognition Disorders - physiopathology ; Cognition Disorders - psychology ; Dementia ; Dementia - pathology ; Dementia - physiopathology ; Dementia - psychology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Neuropsychological Tests ; Prefrontal Cortex - pathology ; Prefrontal Cortex - physiopathology ; Psychophysiology ; Social Behavior</subject><ispartof>Brain (London, England : 1878), 2002-04, Vol.125 (Pt 4), p.752-764</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Apr 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-b72ff7a01193bbb644783319b3243b2bfd17655b3340b0d2eb2567817cdcdfb83</citedby><cites>FETCH-LOGICAL-c413t-b72ff7a01193bbb644783319b3243b2bfd17655b3340b0d2eb2567817cdcdfb83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13554946$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11912109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GREGORY, Carol</creatorcontrib><creatorcontrib>LOUGH, Sinclair</creatorcontrib><creatorcontrib>STONE, Valerie</creatorcontrib><creatorcontrib>ERZINCLIOGLU, Sharon</creatorcontrib><creatorcontrib>MARTIN, Louise</creatorcontrib><creatorcontrib>BARON-COHEN, Simon</creatorcontrib><creatorcontrib>HODGES, John R</creatorcontrib><title>Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications</title><title>Brain (London, England : 1878)</title><addtitle>Brain</addtitle><description>A key aspect of social cognition is the ability to infer other people's mental states, thoughts and feelings; referred to as 'theory of mind' (ToM). We tested the hypothesis that the changes in personality and behaviour seen in frontal variant frontotemporal dementia (fvFTD) may reflect impairment in this cognitive domain. Tests of ToM, executive and general neuropsychological ability were given to 19 fvFTD patients, a comparison group of Alzheimer's disease patients (n = 12) and matched healthy controls (n = 16). Neuropsychiatric assessment was undertaken using the Neuropsychiatric Inventory (NPI). Patients with fvFTD were impaired on all tests of ToM (first-order false belief; second-order false belief; faux pas detection; and Reading the Mind in the Eyes), but had no difficulty with control questions designed to test general comprehension and memory. By contrast, the Alzheimer's disease group failed only one ToM task (second-order false belief), which places heavy demands on working memory. Performance on the faux pas test revealed a double dissociation, with the fvFTD group showing deficits on ToM-based questions and the Alzheimer's disease group failing memory-based questions only. Rank order of the fvFTD patients according to the magnitude of impairment on tests of ToM and their degree of frontal atrophy showed a striking concordance between ToM performances and ventromedial frontal damage. There was a significant correlation between the NPI score and more sophisticated tests of ToM in the fvFTD group. This study supports the hypothesis that patients with fvFTD, but not those with Alzheimer's disease, are impaired on tests of ToM, and may explain some of the abnormalities in interpersonal behaviour that characterize fvFTD.</description><subject>Adult</subject><subject>Aged</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer Disease - psychology</subject><subject>Biological and medical sciences</subject><subject>Cognition - physiology</subject><subject>Cognition Disorders - pathology</subject><subject>Cognition Disorders - physiopathology</subject><subject>Cognition Disorders - psychology</subject><subject>Dementia</subject><subject>Dementia - pathology</subject><subject>Dementia - physiopathology</subject><subject>Dementia - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Prefrontal Cortex - pathology</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychophysiology</subject><subject>Social Behavior</subject><issn>0006-8950</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1LHTEUBuBQlHq17rouQajdODUnXzPTnUhbBaEbXQ_JTMKNzCRjkqvYP-DfNrdzQXDTVT54zgknL0KfgXwH0rJzHZXz5-rJkrr9gFbAJakoCLmHVoQQWTWtIAfoMKV7QoAzKj-iA4AWaKleoZfbtQnxGQeLJ-cH7DyeVXbG54SfXF5jG4PPasSPKjrl83IO2UxziOV6MFOxTmFVii_Gv2vjJhO_JTy4ZFQyP3DePmCy64veojmqfjm5aR7LJrvg0ye0b9WYzPFuPUJ3v37eXl5VN39-X19e3FQ9B5YrXVNra0XKAExrLTmvG8ag1Yxypqm2A9RSCM0YJ5oM1GgqZN1A3Q_9YHXDjtDp0neO4WFjUu4ml3ozjsqbsEldDYJLoP-H0IhGgCAFnryD92ETfRmig1ZwRqSkBZ0tqI8hpWhsN0c3qfjcAem2MXb_YuyWGAv_suu50ZMZ3vAutwK-7oBK5SttVL536c0xIXjLJXsFArao8Q</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>GREGORY, Carol</creator><creator>LOUGH, Sinclair</creator><creator>STONE, Valerie</creator><creator>ERZINCLIOGLU, Sharon</creator><creator>MARTIN, Louise</creator><creator>BARON-COHEN, Simon</creator><creator>HODGES, John R</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications</title><author>GREGORY, Carol ; LOUGH, Sinclair ; STONE, Valerie ; ERZINCLIOGLU, Sharon ; MARTIN, Louise ; BARON-COHEN, Simon ; HODGES, John R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-b72ff7a01193bbb644783319b3243b2bfd17655b3340b0d2eb2567817cdcdfb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer Disease - psychology</topic><topic>Biological and medical sciences</topic><topic>Cognition - physiology</topic><topic>Cognition Disorders - pathology</topic><topic>Cognition Disorders - physiopathology</topic><topic>Cognition Disorders - psychology</topic><topic>Dementia</topic><topic>Dementia - pathology</topic><topic>Dementia - physiopathology</topic><topic>Dementia - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Prefrontal Cortex - pathology</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychophysiology</topic><topic>Social Behavior</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GREGORY, Carol</creatorcontrib><creatorcontrib>LOUGH, Sinclair</creatorcontrib><creatorcontrib>STONE, Valerie</creatorcontrib><creatorcontrib>ERZINCLIOGLU, Sharon</creatorcontrib><creatorcontrib>MARTIN, Louise</creatorcontrib><creatorcontrib>BARON-COHEN, Simon</creatorcontrib><creatorcontrib>HODGES, John R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain (London, England : 1878)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GREGORY, Carol</au><au>LOUGH, Sinclair</au><au>STONE, Valerie</au><au>ERZINCLIOGLU, Sharon</au><au>MARTIN, Louise</au><au>BARON-COHEN, Simon</au><au>HODGES, John R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications</atitle><jtitle>Brain (London, England : 1878)</jtitle><addtitle>Brain</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>125</volume><issue>Pt 4</issue><spage>752</spage><epage>764</epage><pages>752-764</pages><issn>0006-8950</issn><eissn>1460-2156</eissn><coden>BRAIAK</coden><abstract>A key aspect of social cognition is the ability to infer other people's mental states, thoughts and feelings; referred to as 'theory of mind' (ToM). We tested the hypothesis that the changes in personality and behaviour seen in frontal variant frontotemporal dementia (fvFTD) may reflect impairment in this cognitive domain. Tests of ToM, executive and general neuropsychological ability were given to 19 fvFTD patients, a comparison group of Alzheimer's disease patients (n = 12) and matched healthy controls (n = 16). Neuropsychiatric assessment was undertaken using the Neuropsychiatric Inventory (NPI). Patients with fvFTD were impaired on all tests of ToM (first-order false belief; second-order false belief; faux pas detection; and Reading the Mind in the Eyes), but had no difficulty with control questions designed to test general comprehension and memory. By contrast, the Alzheimer's disease group failed only one ToM task (second-order false belief), which places heavy demands on working memory. Performance on the faux pas test revealed a double dissociation, with the fvFTD group showing deficits on ToM-based questions and the Alzheimer's disease group failing memory-based questions only. Rank order of the fvFTD patients according to the magnitude of impairment on tests of ToM and their degree of frontal atrophy showed a striking concordance between ToM performances and ventromedial frontal damage. There was a significant correlation between the NPI score and more sophisticated tests of ToM in the fvFTD group. This study supports the hypothesis that patients with fvFTD, but not those with Alzheimer's disease, are impaired on tests of ToM, and may explain some of the abnormalities in interpersonal behaviour that characterize fvFTD.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11912109</pmid><doi>10.1093/brain/awf079</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Alzheimer Disease - pathology Alzheimer Disease - physiopathology Alzheimer Disease - psychology Biological and medical sciences Cognition - physiology Cognition Disorders - pathology Cognition Disorders - physiopathology Cognition Disorders - psychology Dementia Dementia - pathology Dementia - physiopathology Dementia - psychology Female Humans Male Medical sciences Middle Aged Neuropsychological Tests Prefrontal Cortex - pathology Prefrontal Cortex - physiopathology Psychophysiology Social Behavior |
title | Theory of mind in patients with frontal variant frontotemporal dementia and Alzheimer's disease: theoretical and practical implications |
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