Two HIV-1 Epidemics in Argentina: Different Genetic Subtypes Associated With Different Risk Groups
This study determined the risk behaviors and viral subtypes of HIV-1 found in 134 heterosexual HIV-seroprevalent maternity patients, 41 of their sexual partners (men who have sex with women [MSW]), and 95 homosexual men (men who have sex with men [MSM]) from Buenos Aires, Argentina. Peripheral blood...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2002-04, Vol.29 (4), p.422-426 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | Avila, María M Pando, María A Carrion, Gladys Peralta, Liliana Martinez Salomon, Horacio Carrillo, Manuel Gomez Sanchez, José Maulen, Sergio Hierholzer, Jesse Marinello, Mark Negrete, Mónica Russell, Kevin L Carr, Jean K |
| description | This study determined the risk behaviors and viral subtypes of HIV-1 found in 134 heterosexual HIV-seroprevalent maternity patients, 41 of their sexual partners (men who have sex with women [MSW]), and 95 homosexual men (men who have sex with men [MSM]) from Buenos Aires, Argentina. Peripheral blood mononuclear cells (PBMCs) were purified from blood and used for DNA extraction, amplification, and genotyping by the envelope heteroduplex mobility assay (env HMA).Most of the women had been infected by having sex with an already infected partner (84%), whereas most of the male partners had been infected via drug use (76%). Both the patients and their sexual partners were poorly educated, only 30% having completed secondary school. The MSM study subjects, however, were significantly better educated and had a lower prevalence of injecting drug use.Env HMA subtype F was found in 77% (103 of 134) of the maternity patients, with similar rates in their partners (73%). Most of the remaining samples were env subtype B. All but one of the couples was concordant in subtype. In the MSM risk group, however, only 10% were env HMA subtype F. Ninety percent of the MSM samples were subtype B.There are at least two independent epidemics of HIV-1 infection in Buenos Aires, Argentina. One, in heterosexual men and women, is dominated by env subtype F whereas the other, in homosexual men, is dominated by env subtype B, as determined by env HMA. |
| doi_str_mv | 10.1097/00126334-200204010-00015 |
| format | Article |
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Peripheral blood mononuclear cells (PBMCs) were purified from blood and used for DNA extraction, amplification, and genotyping by the envelope heteroduplex mobility assay (env HMA).Most of the women had been infected by having sex with an already infected partner (84%), whereas most of the male partners had been infected via drug use (76%). Both the patients and their sexual partners were poorly educated, only 30% having completed secondary school. The MSM study subjects, however, were significantly better educated and had a lower prevalence of injecting drug use.Env HMA subtype F was found in 77% (103 of 134) of the maternity patients, with similar rates in their partners (73%). Most of the remaining samples were env subtype B. All but one of the couples was concordant in subtype. In the MSM risk group, however, only 10% were env HMA subtype F. Ninety percent of the MSM samples were subtype B.There are at least two independent epidemics of HIV-1 infection in Buenos Aires, Argentina. One, in heterosexual men and women, is dominated by env subtype F whereas the other, in homosexual men, is dominated by env subtype B, as determined by env HMA.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/00126334-200204010-00015</identifier><identifier>PMID: 11917249</identifier><identifier>CODEN: JDSRET</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>AIDS/HIV ; Argentina - epidemiology ; Biological and medical sciences ; Disease Outbreaks ; Epidemics ; Epidemiology ; Experimental viral diseases and models ; Female ; Fundamental and applied biological sciences. Psychology ; Genes, env - genetics ; Genetics ; Heteroduplex Analysis ; Heterosexuality ; HIV ; HIV Infections - epidemiology ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - genetics ; Homosexuality, Male ; Human immunodeficiency virus ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Molecular Epidemiology ; Pregnancy ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Complications, Infectious - virology ; Viral diseases ; Virology</subject><ispartof>Journal of acquired immune deficiency syndromes (1999), 2002-04, Vol.29 (4), p.422-426</ispartof><rights>2002 Lippincott Williams & Wilkins, Inc.</rights><rights>2002 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Apr 1, 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4445-3429cdf2f4584e65b9f51ff832f47107f3022bca56fab2e8636d18bc39ee121e3</citedby><cites>FETCH-LOGICAL-c4445-3429cdf2f4584e65b9f51ff832f47107f3022bca56fab2e8636d18bc39ee121e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00126334-200204010-00015$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,4595,27901,27902,65206</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13576983$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11917249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avila, María M</creatorcontrib><creatorcontrib>Pando, María A</creatorcontrib><creatorcontrib>Carrion, Gladys</creatorcontrib><creatorcontrib>Peralta, Liliana Martinez</creatorcontrib><creatorcontrib>Salomon, Horacio</creatorcontrib><creatorcontrib>Carrillo, Manuel Gomez</creatorcontrib><creatorcontrib>Sanchez, José</creatorcontrib><creatorcontrib>Maulen, Sergio</creatorcontrib><creatorcontrib>Hierholzer, Jesse</creatorcontrib><creatorcontrib>Marinello, Mark</creatorcontrib><creatorcontrib>Negrete, Mónica</creatorcontrib><creatorcontrib>Russell, Kevin L</creatorcontrib><creatorcontrib>Carr, Jean K</creatorcontrib><title>Two HIV-1 Epidemics in Argentina: Different Genetic Subtypes Associated With Different Risk Groups</title><title>Journal of acquired immune deficiency syndromes (1999)</title><addtitle>J Acquir Immune Defic Syndr</addtitle><description>This study determined the risk behaviors and viral subtypes of HIV-1 found in 134 heterosexual HIV-seroprevalent maternity patients, 41 of their sexual partners (men who have sex with women [MSW]), and 95 homosexual men (men who have sex with men [MSM]) from Buenos Aires, Argentina. Peripheral blood mononuclear cells (PBMCs) were purified from blood and used for DNA extraction, amplification, and genotyping by the envelope heteroduplex mobility assay (env HMA).Most of the women had been infected by having sex with an already infected partner (84%), whereas most of the male partners had been infected via drug use (76%). Both the patients and their sexual partners were poorly educated, only 30% having completed secondary school. The MSM study subjects, however, were significantly better educated and had a lower prevalence of injecting drug use.Env HMA subtype F was found in 77% (103 of 134) of the maternity patients, with similar rates in their partners (73%). Most of the remaining samples were env subtype B. All but one of the couples was concordant in subtype. In the MSM risk group, however, only 10% were env HMA subtype F. Ninety percent of the MSM samples were subtype B.There are at least two independent epidemics of HIV-1 infection in Buenos Aires, Argentina. One, in heterosexual men and women, is dominated by env subtype F whereas the other, in homosexual men, is dominated by env subtype B, as determined by env HMA.</description><subject>AIDS/HIV</subject><subject>Argentina - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Disease Outbreaks</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Experimental viral diseases and models</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, env - genetics</subject><subject>Genetics</subject><subject>Heteroduplex Analysis</subject><subject>Heterosexuality</subject><subject>HIV</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - genetics</subject><subject>Homosexuality, Male</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Molecular Epidemiology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - epidemiology</subject><subject>Pregnancy Complications, Infectious - virology</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0t9rFDEQB_BFFFur_4IEQd9WM_m1iW9HrddCQdCqjyGbnXhp93bXZJej_72pd1oRxKckw2cGhm-qigB9DdQ0bygFpjgXNaOUUUGB1rTU5IPqGIwQdaO1eFjukslaAJdH1ZOcr4tQQpjH1RGAgYYJc1y1V7uRnF98qYGcTbHDbfSZxIGs0jcc5ji4t-RdDAFTeZE1DjhHTz4t7Xw7YSarnEcf3Ywd-RrnzR_0Y8w3ZJ3GZcpPq0fB9RmfHc6T6vP7s6vT8_ryw_ridHVZeyGErLlgxneBBSG1QCVbEySEoHmpNECbwCljrXdSBdcy1IqrDnTruUEEBshPqlf7uVMavy-YZ7uN2WPfuwHHJdsGpJAS-H8haGG0bpoCX_wFr8clDWUJyzhXnGqlCtJ75NOYc8JgpxS3Lt1aoPYuLfsrLfs7LfszrdL6_DB_abfY3Tce4ing5QG47F0fkht8zPeOy0YZfbeR2Lvd2M-Y8k2_7DDZDbp-3th__Rb-A3Usqgo</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>Avila, María M</creator><creator>Pando, María A</creator><creator>Carrion, Gladys</creator><creator>Peralta, Liliana Martinez</creator><creator>Salomon, Horacio</creator><creator>Carrillo, Manuel Gomez</creator><creator>Sanchez, José</creator><creator>Maulen, Sergio</creator><creator>Hierholzer, Jesse</creator><creator>Marinello, Mark</creator><creator>Negrete, Mónica</creator><creator>Russell, Kevin L</creator><creator>Carr, Jean K</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Two HIV-1 Epidemics in Argentina: Different Genetic Subtypes Associated With Different Risk Groups</title><author>Avila, María M ; Pando, María A ; Carrion, Gladys ; Peralta, Liliana Martinez ; Salomon, Horacio ; Carrillo, Manuel Gomez ; Sanchez, José ; Maulen, Sergio ; Hierholzer, Jesse ; Marinello, Mark ; Negrete, Mónica ; Russell, Kevin L ; Carr, Jean K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4445-3429cdf2f4584e65b9f51ff832f47107f3022bca56fab2e8636d18bc39ee121e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>AIDS/HIV</topic><topic>Argentina - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Disease Outbreaks</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Experimental viral diseases and models</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, env - genetics</topic><topic>Genetics</topic><topic>Heteroduplex Analysis</topic><topic>Heterosexuality</topic><topic>HIV</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - genetics</topic><topic>Homosexuality, Male</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Molecular Epidemiology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - epidemiology</topic><topic>Pregnancy Complications, Infectious - virology</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avila, María M</creatorcontrib><creatorcontrib>Pando, María A</creatorcontrib><creatorcontrib>Carrion, Gladys</creatorcontrib><creatorcontrib>Peralta, Liliana Martinez</creatorcontrib><creatorcontrib>Salomon, Horacio</creatorcontrib><creatorcontrib>Carrillo, Manuel Gomez</creatorcontrib><creatorcontrib>Sanchez, José</creatorcontrib><creatorcontrib>Maulen, Sergio</creatorcontrib><creatorcontrib>Hierholzer, Jesse</creatorcontrib><creatorcontrib>Marinello, Mark</creatorcontrib><creatorcontrib>Negrete, Mónica</creatorcontrib><creatorcontrib>Russell, Kevin L</creatorcontrib><creatorcontrib>Carr, Jean K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avila, María M</au><au>Pando, María A</au><au>Carrion, Gladys</au><au>Peralta, Liliana Martinez</au><au>Salomon, Horacio</au><au>Carrillo, Manuel Gomez</au><au>Sanchez, José</au><au>Maulen, Sergio</au><au>Hierholzer, Jesse</au><au>Marinello, Mark</au><au>Negrete, Mónica</au><au>Russell, Kevin L</au><au>Carr, Jean K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two HIV-1 Epidemics in Argentina: Different Genetic Subtypes Associated With Different Risk Groups</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>29</volume><issue>4</issue><spage>422</spage><epage>426</epage><pages>422-426</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><coden>JDSRET</coden><abstract>This study determined the risk behaviors and viral subtypes of HIV-1 found in 134 heterosexual HIV-seroprevalent maternity patients, 41 of their sexual partners (men who have sex with women [MSW]), and 95 homosexual men (men who have sex with men [MSM]) from Buenos Aires, Argentina. Peripheral blood mononuclear cells (PBMCs) were purified from blood and used for DNA extraction, amplification, and genotyping by the envelope heteroduplex mobility assay (env HMA).Most of the women had been infected by having sex with an already infected partner (84%), whereas most of the male partners had been infected via drug use (76%). Both the patients and their sexual partners were poorly educated, only 30% having completed secondary school. The MSM study subjects, however, were significantly better educated and had a lower prevalence of injecting drug use.Env HMA subtype F was found in 77% (103 of 134) of the maternity patients, with similar rates in their partners (73%). Most of the remaining samples were env subtype B. All but one of the couples was concordant in subtype. In the MSM risk group, however, only 10% were env HMA subtype F. Ninety percent of the MSM samples were subtype B.There are at least two independent epidemics of HIV-1 infection in Buenos Aires, Argentina. One, in heterosexual men and women, is dominated by env subtype F whereas the other, in homosexual men, is dominated by env subtype B, as determined by env HMA.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>11917249</pmid><doi>10.1097/00126334-200204010-00015</doi><tpages>5</tpages></addata></record> |
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| subjects | AIDS/HIV Argentina - epidemiology Biological and medical sciences Disease Outbreaks Epidemics Epidemiology Experimental viral diseases and models Female Fundamental and applied biological sciences. Psychology Genes, env - genetics Genetics Heteroduplex Analysis Heterosexuality HIV HIV Infections - epidemiology HIV Infections - virology HIV-1 - classification HIV-1 - genetics Homosexuality, Male Human immunodeficiency virus Humans Infectious diseases Male Medical sciences Microbiology Molecular Epidemiology Pregnancy Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - virology Viral diseases Virology |
| title | Two HIV-1 Epidemics in Argentina: Different Genetic Subtypes Associated With Different Risk Groups |
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