Thalamic gray matter changes in unilateral Parkinsonian resting tremor: a voxel-based morphometric analysis of 3-dimensional magnetic resonance imaging
The thalamus is assumed to be involved in the generation of Parkinsonian tremor. Ten patients with tremor-dominant idiopathic Parkinson's disease (IPD) and strictly unilateral resting tremor were investigated by cerebral high-resolution 3-dimensional magnetic resonance imaging (MRI). MRI data w...
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| Veröffentlicht in: | Neuroscience letters 2002-04, Vol.323 (1), p.29-32 |
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| creator | Kassubek, Jan Juengling, Freimut D. Hellwig, Bernhard Spreer, Joachim Lücking, Carl H. |
| description | The thalamus is assumed to be involved in the generation of Parkinsonian tremor. Ten patients with tremor-dominant idiopathic Parkinson's disease (IPD) and strictly unilateral resting tremor were investigated by cerebral high-resolution 3-dimensional magnetic resonance imaging (MRI). MRI data were analyzed by an observer-independent morphometric technique, voxel-based morphometry (VBM). For VBM, MRI data were automatically normalized and segmented, then gray matter volumes were analyzed on a voxel-by-voxel basis in comparison to an age-matched control group using Statistical Parametric Mapping (SPM99). Highly significant structural changes, i.e. locally increased gray matter concentrations (
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| doi_str_mv | 10.1016/S0304-3940(02)00111-8 |
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P<0.001), were found in the nucleus ventralis intermedius (VIM) of the thalamus contralateral to the tremor side and were significantly covariant with tremor amplitudes. On the one hand, these changes were localized in close vicinity to a thalamic focal hypermetabolism as revealed by a previous positron emission tomography study in unilateral Parkinsonian tremor patients. On the other hand, the localization of the focal structural changes in VIM corresponds with the generally accepted target area of tremor surgery in IPD.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(02)00111-8</identifier><identifier>PMID: 11911983</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aged ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Humans ; Imaging, Three-Dimensional ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Neurology ; Parkinson Disease - pathology ; Parkinson Disease - physiopathology ; Parkinson's disease ; Statistical parametric mapping ; Thalamus ; Thalamus - pathology ; Tremor ; Tremor - etiology ; Voxel-based morphometry</subject><ispartof>Neuroscience letters, 2002-04, Vol.323 (1), p.29-32</ispartof><rights>2002 Elsevier Science Ireland Ltd</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-991129061b314da49035b7c050d258295dcaa9416bdf6ead80da2de4f465b3123</citedby><cites>FETCH-LOGICAL-c509t-991129061b314da49035b7c050d258295dcaa9416bdf6ead80da2de4f465b3123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(02)00111-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13551195$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11911983$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kassubek, Jan</creatorcontrib><creatorcontrib>Juengling, Freimut D.</creatorcontrib><creatorcontrib>Hellwig, Bernhard</creatorcontrib><creatorcontrib>Spreer, Joachim</creatorcontrib><creatorcontrib>Lücking, Carl H.</creatorcontrib><title>Thalamic gray matter changes in unilateral Parkinsonian resting tremor: a voxel-based morphometric analysis of 3-dimensional magnetic resonance imaging</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The thalamus is assumed to be involved in the generation of Parkinsonian tremor. Ten patients with tremor-dominant idiopathic Parkinson's disease (IPD) and strictly unilateral resting tremor were investigated by cerebral high-resolution 3-dimensional magnetic resonance imaging (MRI). MRI data were analyzed by an observer-independent morphometric technique, voxel-based morphometry (VBM). For VBM, MRI data were automatically normalized and segmented, then gray matter volumes were analyzed on a voxel-by-voxel basis in comparison to an age-matched control group using Statistical Parametric Mapping (SPM99). Highly significant structural changes, i.e. locally increased gray matter concentrations (
P<0.001), were found in the nucleus ventralis intermedius (VIM) of the thalamus contralateral to the tremor side and were significantly covariant with tremor amplitudes. On the one hand, these changes were localized in close vicinity to a thalamic focal hypermetabolism as revealed by a previous positron emission tomography study in unilateral Parkinsonian tremor patients. On the other hand, the localization of the focal structural changes in VIM corresponds with the generally accepted target area of tremor surgery in IPD.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Imaging, Three-Dimensional</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Statistical parametric mapping</subject><subject>Thalamus</subject><subject>Thalamus - pathology</subject><subject>Tremor</subject><subject>Tremor - etiology</subject><subject>Voxel-based morphometry</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhoModq3-BCU3Sr0YPclM5sMbkeIXFBSs1-FMcmY3OpPZJrOl-0v8u552F3spBAIvz_l6XyGeK3ijQNVvf0AJVVF2FZyBfg2glCraB2Kl2kYXTdfoh2L1DzkRT3L-BQBGmeqxOFGq49eWK_HncoMjTsHJdcK9nHBZKEm3wbimLEOUuxhGZA1H-R3T7xDzHANGmSgvIa7lkmia0zuJ8nq-obHoMZOXLG0380RL4s4YcdznkOU8yLLwYaKYw8wij1tHWhjhbixERzKwxn2fikcDjpmeHf9T8fPTx8vzL8XFt89fzz9cFM5AtxQd36E7qFVfqspj1UFp-saBAa9NqzvjHWJXqbr3Q03oW_CoPVVDVRsu0eWpeHXou03z1Y5vslPIjsYRI827bBs2zGioGDQH0KU550SD3SbeNe2tAnubiL1LxN7abUHbu0Rsy3UvjgN2_UT-vuoYAQMvjwBmh-OQ2IaQ77nSGAYNc-8PHLEd14GSzS4QW-ZDIrdYP4f_rPIX-iWqpQ</recordid><startdate>20020419</startdate><enddate>20020419</enddate><creator>Kassubek, Jan</creator><creator>Juengling, Freimut D.</creator><creator>Hellwig, Bernhard</creator><creator>Spreer, Joachim</creator><creator>Lücking, Carl H.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020419</creationdate><title>Thalamic gray matter changes in unilateral Parkinsonian resting tremor: a voxel-based morphometric analysis of 3-dimensional magnetic resonance imaging</title><author>Kassubek, Jan ; Juengling, Freimut D. ; Hellwig, Bernhard ; Spreer, Joachim ; Lücking, Carl H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-991129061b314da49035b7c050d258295dcaa9416bdf6ead80da2de4f465b3123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Imaging, Three-Dimensional</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Statistical parametric mapping</topic><topic>Thalamus</topic><topic>Thalamus - pathology</topic><topic>Tremor</topic><topic>Tremor - etiology</topic><topic>Voxel-based morphometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kassubek, Jan</creatorcontrib><creatorcontrib>Juengling, Freimut D.</creatorcontrib><creatorcontrib>Hellwig, Bernhard</creatorcontrib><creatorcontrib>Spreer, Joachim</creatorcontrib><creatorcontrib>Lücking, Carl H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kassubek, Jan</au><au>Juengling, Freimut D.</au><au>Hellwig, Bernhard</au><au>Spreer, Joachim</au><au>Lücking, Carl H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thalamic gray matter changes in unilateral Parkinsonian resting tremor: a voxel-based morphometric analysis of 3-dimensional magnetic resonance imaging</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2002-04-19</date><risdate>2002</risdate><volume>323</volume><issue>1</issue><spage>29</spage><epage>32</epage><pages>29-32</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The thalamus is assumed to be involved in the generation of Parkinsonian tremor. Ten patients with tremor-dominant idiopathic Parkinson's disease (IPD) and strictly unilateral resting tremor were investigated by cerebral high-resolution 3-dimensional magnetic resonance imaging (MRI). MRI data were analyzed by an observer-independent morphometric technique, voxel-based morphometry (VBM). For VBM, MRI data were automatically normalized and segmented, then gray matter volumes were analyzed on a voxel-by-voxel basis in comparison to an age-matched control group using Statistical Parametric Mapping (SPM99). Highly significant structural changes, i.e. locally increased gray matter concentrations (
P<0.001), were found in the nucleus ventralis intermedius (VIM) of the thalamus contralateral to the tremor side and were significantly covariant with tremor amplitudes. On the one hand, these changes were localized in close vicinity to a thalamic focal hypermetabolism as revealed by a previous positron emission tomography study in unilateral Parkinsonian tremor patients. On the other hand, the localization of the focal structural changes in VIM corresponds with the generally accepted target area of tremor surgery in IPD.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>11911983</pmid><doi>10.1016/S0304-3940(02)00111-8</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Imaging, Three-Dimensional Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Neurology Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson's disease Statistical parametric mapping Thalamus Thalamus - pathology Tremor Tremor - etiology Voxel-based morphometry |
| title | Thalamic gray matter changes in unilateral Parkinsonian resting tremor: a voxel-based morphometric analysis of 3-dimensional magnetic resonance imaging |
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