Statistical Analysis of Noninferiority Trials with a Rate Ratio in Small-Sample Matched-Pair Designs

Testing of noninferiority has become increasingly important in modern medicine as a means of comparing a new test procedure to a currently available test procedure. Asymptotic methods have recently been developed for analyzing noninferiority trials using rate ratios under the matched-pair design. In...

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Veröffentlicht in:	Biometrics 2003-12, Vol.59 (4), p.1170-1177
Hauptverfasser:	Chan, Ivan S. F., Tang, Nian-Sheng, Tang, Man-Lai, Chan, Ping-Shing
Format:	Artikel
Sprache:	eng
Schlagworte:	Approximate exact tests Asymptotic methods Biometrics Biometry - methods Clinical Trials as Topic Confidence interval Confidence Intervals Conservatism Consultant's Forum Design analysis Error rates Exact unconditional inference Humans Models, Statistical Noninferiority trials P values Probabilities Proportions Rate ratio Reproducibility of Results Research Design Sample Size Score statistic Statistics Test-based confidence interval
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